Customer Reviews:
Epigenetics - a timely and important text........2007-05-15
It is becoming clear that epigenetic mechanisms are responsible for a large number of "genetic" events in the organism, both under normal and pathological circumstances. This advanced text (suitable for advanced undergraduates and beginning graduate students) brings together, in a very readable way, the various mechanisms of epigenetic heredity.
An invaluable educational tool.......2007-04-11
Epigenetics is a scientific textbook written to teach advanced undergraduate and graduate college students about epigenetic mechanisms, which regulate gene expression in many biological processes. Chapters cover histone modifications, chromatin remodeling, DNA methylation, siRNAs and gene silencing, X-chromosome inactivation, epigenetics in microbes, plants, insects and mammals, and much more. An in-depth, scholarly, and informative instructional reference, interspersed with occasional color photographs and diagrams, featuring an extensive list of references and a general summary at the end of each chapter to aid comprehension. An invaluable educational tool for specialized college science courses, as well as for professionals in the field of biology seeking to sharpen their understanding of modern epigenetics.
Represents the Current State of the Art.......2006-12-19
Wikipedia says: 'Epigenetics is the study of epigenetic inheritance, a set of reversible heritable changes in gene function or other cell phenotype that occur without a change in DNA sequence (genotype).'
That's a pretty general definition, and you can get into some pretty good arguments that this or that word should be changed.
The fundamental discoveries that began the field began to be discussed in 1941, but it grew slowly until fairly recent years. By 2004 the science had developed enough that the 69th Cold Spring Harbor Symposium on Quantitative Biology covered the topic. Many of the authors of this book attended that symposium and the seeds for this book were sown.
The book was written by about forty of the preeminent researchers in the field. It consists of 24 chapters covering virtually all known aspects of the subject. It can serve as a reference work for the current state of the art, or could be used as a text for advanced undergraduate or graduate courses on gene regulation.
Book Description
Ideas about heredity and evolution are undergoing a revolutionary change. New findings in molecular biology challenge the gene-centered version of Darwinian theory according to which adaptation occurs only through natural selection of chance DNA variations. In Evolution in Four Dimensions, Eva Jablonka and Marion Lamb argue that there is more to heredity than genes. They trace four "dimensions" in evolution -- four inheritance systems that play a role in evolution: genetic, epigenetic (or non-DNA cellular transmission of traits), behavioral, and symbolic (transmission through language and other forms of symbolic communication). These systems, they argue, can all provide variations on which natural selection can act. Evolution in Four Dimensions offers a richer, more complex view of evolution than the gene-based, one-dimensional view held by many today. The new synthesis advanced by Jablonka and Lamb makes clear that induced and acquired changes also play a role in evolution.
After discussing each of the four inheritance systems in detail, Jablonka and Lamb "put Humpty Dumpty together again" by showing how all of these systems interact. They consider how each may have originated and guided evolutionary history and they discuss the social and philosophical implications of the four-dimensional view of evolution. Each chapter ends with a dialogue in which the authors engage the contrarieties of the fictional (and skeptical) "I.M.," or Ifcha Mistabra -- Aramaic for "the opposite conjecture" -- refining their arguments against I.M.'s vigorous counterarguments. The lucid and accessible text is accompanied by artist-physician Anna Zeligowski's lively drawings, which humorously and effectively illustrate the authors' points.
Customer Reviews:
A hic-up revision.......2007-05-13
The refreshing part of the book is that Darwin is postulated to trump the Modern Synthesis by offering a broader and vaguer model. Mostly however, allusions and overinterpretations of re-hashed phenomena and a few recent twists like siRNA, are offered as still-unconvincing examples in a systematic attempt to argue epigenetics as having important biological and evolutionary roles. Yes, some aspects of biology and evolution are somewhat complex, but vague hand waving about epigenetics does not clarify them.
Well written, but unnecessarily long.......2007-03-26
This book provides a comprehensive but not overly technical survey of our state of knowledge as to how evolution proceeds and, in particular, why change is not totally random. They point out that there is an evolutionary bias to select organisms whose DNA is conducive to evolution, because they are more likely to have "random" mutations which are favorable; that mutation rates increase under stress such as a change in the environment; that the folding properties of DNA insure that it is the more active sections of DNA that are likely to have mutations.
The thrust of this book, however, and the material most likely to be unfamiliar to lay students of the subject, is in support of a neo-Lamarckian viewpoint, in which environment can more directly impact inheritable change. There is one beautiful experiment which illustrates the neo-Larmarckian view, with flies: stress causes genetic mutation resulting, in some flies, in a particular deformity; if these flies are selected for further breeding (as if that mutation were a successful adaptation), and this is done for 16 generations, you finally get flies which have this deformity in the absence of the stressor. The theory is that organisms accumulate genetic differences which do not impact phenotype, in fact phenotypes tend to be insensitive to many mutations, but once there is sufficient environmental stress these genetic differences manifest themselves.
While epigenetics is a hot topic in the study of development, this book makes a case for epigenetic mutation as a basis for evolution. It also talks about what I would term a generalization of cultural inheritance wherein the inherited behavior does not depend on teaching or watching: for example, a young rabbit learns what is good to eat through the effects in the womb of what his mother eats, and what is in the mother's feces while the youngster is in the burrow.
The authors write very well, and are clearly mindful of the reader's comprehension. The discussion of the material at the end of each chapter is a wonderful idea. Still, I would have preferred a shorter work, without so much emphasis on philosophical subtleties: an idea like the "selfish gene" is not a scientific theory to be debated, but a way of looking at things which can be suggestive and lead to new findings, but of course has its limitations. A picture, or an experiment, is worth a thousand words. Currently, unfortunately, the evidence to support the book's ideas is often thin, in fact one objective of the authors is certainly to encourage more research. In one very interesting case they seem to make too little of the evidence: the author's accept that a young bonobo, watching experimenters teaching language to his mother, developed the understanding of a 2.5 year old human, including word order and other grammatical structures, but did not mention this in their initial discussions of language or really come to terms with it.
Evolution in Four Dimensions.......2007-01-10
With this book the authors expand the conventional 20th century view of the theory of evolution to include epigenetic, psychological and sociological evolution. The most interesting "inherited" addition for me is epigenetic evolution: the theory that many of our human qualities were passed down from ancestors without involving genetic variation. I can myself think of candidate markers that would best fit into the authors's theory. All in all, the book is very well written; my only criticism is that I could have done without some of the stick-figure drawings. But it is still a very good read for anyone who thinks evolution is a well-established scientific fact and who is not afraid to intellectually challenge the majority-held belief in the "absolute" truths of religious doctrines and dogma.
Great Book. Wish it Were Better........2006-09-25
This is such a good book, I wish it were better. In particular, I wish that the authors had not spent so much time discussing the effects of informational and symbolic transmission on evolution (most of which is fairly obvious) and spent more time on the fascinating topics of epigentic transmission and genetic control systems, which are extremely complex and difficult issues, and go by too fast.
The authors pose a question that evolutionary scholar rarely broach: If evolution produces and preserves adaptive traits, why does it not produce the trait that is the most adaptive of all -- the ability to directly transmit acquired adaptive characteristics to offspring? Ironically, despite their qualified claim that organisims do have such an ability, the authors provide an excellent Darwinian reason why this trait is so limited -- because a species which possesses it (like, say, humans) is so likely to "crash and burn" if it mistakenly adopts a trait which turns out to be maladaptive.
Jablonski and her co-author are neo-Lamarkians; that is, they believe (or want to believe) in the inheritance of acquired characterists. Lamarkism is deeply distrusted by evolutionary biologists for two very good reasons: there is not much evidence for it, and a mechanism for transmitting acquired characteristics seems biochemically impossible. The authors present some good arguments why this might not be so. Particulary impressive is their discussion of epigenetics -- biochemical processess not involving genes which nonethelesss affect an organism's development. Epigenetic processes pretty clearly can be affected by environmental factors, and so environmental factors do have a direct impact on bodily devlopment, and hence evolution. More relevantly, epigentic developments can apparently be directly incorporated into the organism's germ line (the system which involves reproduction), and hence heredity, without the necessity of mutation. This issue is deep and difficult probably deserved a whole book of its own.
The writing is clear and the illustrations are helpful, if a bit "cute." This book is a wonderful introduction to a problematical subject. Persons who are suspicious of classical Darwinism, but suspect that intelligent design theory is nonsense will love this book.
What goes around comes around.......2006-02-19
In 1829 Jean-Baptiste Lamarck, who wrote voluminous evolutionary ideas, was buried, virtually penniless, in a rented grave. There was no rest for the weary or the dead when decades later August Weismann cut off the tails of twenty-two generations of mice, discrediting Lamarck's idea of acquired characteristics and driving yet another nail into the poor man's coffin. (For more about Lamarck's life and ideas see J. B. Lamarck, Zoological Philosophy, Univ. of Chicago Press, 1984 and the insightful comments by Richard W. Burkhardt and David Hull therein).
As Lamarck was interred, his daughter remarked that the future would avenge him. It appears that time has come. Eva Jablonka and Marion J. Lamb's Evolution in Four Dimensions provides an extraordinary explication and synthesis of hereditary mechanisms (genetic, epigenetic, behavioral and symbolic) that may be called Neo-Lamarckian - the set of ideas that extend heritable, adaptive changes beyond natural selection to include "...internal (evolved) systems that generate "intelligent guesses" in response to the conditions of life." (p. 361). The mechanisms Jablonka and Lamb explore include, but go well beyond, the 20th century concepts that locked inheritance inside Mendel's merkmal or Crick's Central Dogma or Morgan's Drosophila chromosomes and observable traits. In so doing, the authors make an important contribution to the 21st century paradigm about heredity that is a-building. (Other contributions include: Mary Jane West-Eberhard's Developmental Plasticity and Evolution, Oxford Univ. Press, 2003; Massimo Pigliucci's Phenotypic Plasticity, Johns Hopkins Univ. Press, 2001; Gilbert Gottlieb's Synthesizing Nature-Nurture, Lawrence Erlbaum, 1997).
Dr. Jablonka, Professor of Biology at the acclaimed Cohn Institute in Israel and Ms. Lamb, formerly Senior Lecturer, Birkbeck College, University of London, extend the ideas in their previous work (Epigenetic Inheritance and Evolution, Oxford Univ. Press, 1995; The changing concept of epigenetics, New York Academy of Sciences, 2002, 981, 82-96.) The book is divided into three parts. In the first, the authors provide a fine summary of the modern development of evolutionary ideas, and the most detailed and extensive description of genetic mechanisms that I have found in a book aimed at a general readership. Almost certainly, anyone reading Chapter Two (From Genes to Characters) and Chapter Three (Genetic Variation: Blind, Directed, Interpretive?) will eschew conventional notions of "The gene for...." that are everyday fare in the media.
Chapter Four on epigenetics brings us back to those long-suffering mouse families whose tails were chopped off. As the experiments Jablonka and Lamb cite here indicate, had Herr Docktor Weismann manipulated a molecule during development, instead of a machete, he would have been able to alter the intergenerational transfer of characters. Chapter Five describes and analyzes behavioral inheritance systems particularly social learning and Chapter Six does the same for symbolic inheritance systems including cultural evolution and symbolic communication. Chapter Seven integrates genetic and epigenetic inheritance systems. Chapter Eight accomplishes the same for genes, behavior and language. Chapter Nine presents a Neo-Lamarckian perspective on heredity and evolutionary theory that might well have warmed Charles Darwin's heart because it is based on a closely reasoned collection of empirical data rather than the less well grounded speculations that are associated with Lamarck. Throughout, the authors take us on an intellectual journey from inside the cell up the abstraction ladder to the cultures we live in. For a related treatment cf. A.R. Cellura, The Genomic Environment and Niche-Experience, Cedar Springs Press, 2005.
There are two other features of Evolution in Four Dimensions that are particularly noteworthy. Implicit in most modern scientific theorizing is the notion of challenging hypotheses that Popper made idiomatic with his Conjectures and Refutations (Harper & Row, 1963). Consistent with this, Jablonka and Lamb aim at further insight through a dialogue at the end of each chapter between Ifcha Mistabra (Aramaic for opposite conjecture) and themselves. Also, it would be hugely neglectful not to mention the imp that got out of the ink bottle - the delightful drawings of Anna Zeligowski that illustrate key points in the text.
Evolution in Four Dimensions is a jewel readily accessible to educated readers with an interest in human adaptation over the short and the long haul.
Book Description
Author Dawson Church applies the insights of the new field of Epigenetics (epi=above, i.e. control above the level of the gene) to healing. Citing hundreds of scientific studies, he shows how beliefs and emotions can trigger the expression of DNA strands. He focuses on a class of genes called Immediate Early Genes or IEGs. These genes turn on within a few seconds of a stimulus. They can be triggered by thoughts or emotions ("I loved that unexpected gift of roses Bill gave me" or "I'm so mad about what Uncle John said at the Christmas party"). Many IEGs are regulatory genes turn on other genes that affect specific aspects of our immune system, such as the production of white blood cells that destroy attacking bacteria and viruses. Epigenetics thus influences our health every day.
He coins the new term "Epigenetic Medicine" to describe healing techniques with epigenetic effects. He also summarizes the science behind the infant fields of Energy Psychology and Energy Medicine, both of which offer promising epigenetic medical therapies, and describes a few of the thousands of powerful personal breakthroughs that are being achieved by therapists, doctors and lay people praticing these techniques. The Genie in Your Genes shows that there is a sound theoretical framework, based on credible experiments, for understanding these astonishing results, and predicts that the insights of Epigenetic Medicine will dramatically advance the fields of both medicine and psychology in the coming decade.
Best of all, The Genie in Your Genes demonstrates that, by taking control of our consciousness and using it to influence our genetic expression, we can sometimes bypass years of therapy, as well as harmful drugs and invasive surgeries, to, in effect, do continuous genetic engineering on our own bodies. This can produce both immediate relief from long-standing anxieties and neuroses, as well as "miraculous" healing of persistent physical conditions, especially autoimmune diseases.
Among a new crop of books that chart the way to a positive health future, The Genie in Your Genes stands out as a solidly grounded and exciting pointer to the future possibilities of a medicine that links soul to body and mind.
Customer Reviews:
Worth a new thought process.......2007-08-23
This is a wonderful book, especially if you are looking for an entirely new thought process for dealing with your best companion, your own body. This book is very empowering when the traditional healing methods are not quite enough; or as an additional form of assistance. The mind is a wonder.
At last proof I'm not just a mad therapist.......2007-08-20
As an EFT therapist I am accustomed to cynics and even some highly qualified therapists who don't believe we are energy, at last a book that explains it all. It will open the doors to quicker healing.
I have the power!!!.......2007-08-12
What an amazing book... if you thought that everything is set and done with your genes, you're wrong... YOU can change everything... In some parts the book is a little "nerdy" with a lot of physiology that may be hard if you don't know how the body works its chemicals, but just read through it, even if you don't understand, you will see the big picture, and it's a nice one... made me laugh and wonder.... :0)
Stretch your envelope.......2007-08-01
I loved this book. This new, cutting-edge research turns the whole science of genetics on its head and opens a new reality of infinite possibilities... and it's written engagingly as well.
Enlightening.......2007-07-16
I've only read the first few chapters so far but I'm hooked. I am a firm believer that you can't attach either total or the majority of "the blame" on any one factor when it comes to the human body and mind. The fact that so many doctors of high caliber endorsed this book was my incentive to purchase it, rather than borrow it from the library. Not an easy read but not difficult either - I really enjoy books that open my mind to new concepts!
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Epigenetics Protocols (Methods in Molecular Biology)
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Epigenetics
ASIN: 158829336X |
Book Description
A collection of state-of-the-art methods for epigenetic analysis, including recent breakthrough techniques that have great potential in the rapidly expanding field of non-Mendelian genetics. The authors provide techniques for the analysis of chromatin remodeling, such as histone acetylation and methylation. In addition, methods in newly developed and especially promising areas of epigenetics, such as telomere position effects, quantitative epigenetics, and ADP ribosylation are covered. There is also an updated analysis of techniques involving DNA methylation and its role in the modification, as well as the maintenance, of chromatin structure. Of special interest are potentially revolutionary techniques. These include methods for determining changes in native chromatin, methods of microarray analysis applied to epigenetics, and methylation-sensitive single-strand conformation techniques. The methods are suitable not only for studying fundamental biological processes, but also for investigating possible therapeutic interventions and such diseases as cancer.
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Mental Retardation and Developmental Delay: Genetic and Epigenetic Factors (Oxford Monographs on Medical Genetics)
Moyra Smith
Manufacturer: Oxford University Press, USA
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ASIN: 0195174321 |
Book Description
Recent advances in neuroscience and genetics have greatly expanded our understanding of the brain and of the etiological factors involved in developmental delay and mental retardation. At the same time, the human genome project has yielded a wealth of information on DNA sequencing, regulation of gene expression, epigenetics, and functional aspects of the genome, which newly propels investigation into the pathogenesis of mental retardation. This book makes readily available current knowledge on the subject and applies it to clinical medicine, providing information essential to neurologists, geneticists, physicians and pediatricians as they search for the causes of mental handicap in their patients. Introductory chapters cover normal and abnormal brain structure, neurogenesis, neuronal proliferation, and signal transduction. Latter chapters delve into discussions of both the environmental factors that may lead to neurocognitive deficits and the cytogenetic, biochemical and molecular defects specifically associated with mental retardation. One chapter reviews gene involvement in non-syndromic mental retardation, autism, and language deficits, as well as multifactorial and genetically complex inheritance. The text concludes with a clinically practical discussion of carrier detection, presymptomatic diagnosis, and treatment of various genetic diseases through enzyme therapy, substrate deprivation, and the use of hemapoietic stem cells.
Book Description
This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment.The objectives of the papers include defining the terminology used in epigenetics, identifying and prioritizing areas of research in epigenetics, reviewing cutting-edge technology available for quantitation of methylation and high-throughput assays, and discussing clinical correlates to epigenetic changes.
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Epigenetic Variants of the Human Skull
Gertrud Hauser , and
G. F. De Stefano
Manufacturer: E. Schweizerbartsche Verlagsbuchhandlung
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DNA Methylation: Basic Mechanisms (Current Topics in Microbiology and Immunology)
Manufacturer: Springer
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ASIN: 3540291148 |
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The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is, unfortunately, not well understood. The stability, inheritability, and developmental flexibility of these patterns all point to a major role that these patterns appear to play in determining structure and funtion of the genome. Up to the present time, studies on the repetitive sequences, which comprise more than 90 per cent of the DNA sequences in the human or other genomes, have been neglected.
Book Description
Written in an informal and accessible style, Chromatin and Gene Regulation enables the reader to understand the science of this rapidly moving field. Chromatin is a fundamental component in the network of controls that regulates gene expression. Many human diseases have been linked to disruption of these control processes by genetic or environmental factors and unravelling the mechanisms by which they operate is one of the most exciting and rapidly developing areas of modern biology. Chromatin is central both to the rapid changes in gene transcription by which cells respond to changes in their environment and also to the maintenance of gene expression patterns from one cell generation to the next. This book will be an invaluable guide to undergraduate and postgraduate students in the biological sciences and all those with an interest in the medical implications of aberrant gene expression.
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From Epigenesis to Epigenetics: The Genome in Context (Annals of the New York Academy of Sciences, Vol 981)
Manufacturer: New York Academy of Sciences
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- Essential Cell Biology, Second Edition
- Essentials of Human Anatomy and Physiology
- Evolutionary Conservation Biology (Cambridge Studies in Adaptive Dynamics)
- Evolutionary Conservation Biology (Cambridge Studies in Adaptive Dynamics)
- Evolutionary Dynamics: Exploring the Equations of Life
- Evolutionary Pathways in Nature: A Phylogenetic Approach
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- Fisher-Price: Historical, Rarity, and Value Guide, 1931-Present (Fisher-Price: a Historical, Rarity & Value Guide)
- Fishes: A Field and Laboratory Manual on Their Structure, Identification and Natural History
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