Molecular Biology of the Cell, Fourth Edition

Book Description

Molecular Biology of the Cell is the classic in-depth text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains unknown.
The hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice.

Customer Reviews:

bio book.......2007-09-15

the book is amazing. i got it in great shape, and aside from it weighing 7 lbs...it's a great book for a biology class.

Best Science Book I've Ever Read.......2007-07-09

If you are taking a cell biology book, this is the book to read. Even if your instructor assigns a lighter book, you can still read this and benefit. It's one of those rare books that go into the details while still being readible. It's incredibly well organized and well written.

A thousand carats text!.......2007-06-27

The undeniable importance of the molecular biology has achieved in the last two decades such transcendental outburst of energy, advances and extraordinary finfings that hardly we should devote entirely to be informed about the multiple consequences of its profound implications.

This book is a true effort worthy to admire, because it has been written with this kind spirit of sharing the knowledge wothout pretensions or any other considerations.

Once you open it, you will be absoltely engaged due its relevant interest, because of the fact there`s a lot of secondnary readings and discoveries all over the world that it should be be stated of this way. May one not being aware about the structure of the cell and the mesmerizing devices the nature employs to show us its lavish dynamics.

Additionally the support material of this CD ROM simply is priceless. I insist, you don't need to be an expert in this issue to start.

Decide by yourself and please, dont wait so long.

Molecurar biology of the cell.......2007-05-18

It's a very complete and updated book about all items refered to molecular biology of the cell. I specially use it for all the information I need for the 1st year of Medicine School.
Very recomendable

This book is awesome........2007-05-17

It really gets you into the bioscientific mind type of reasoning.

Practical Homicide Investigation: Tactics, Procedures, and Forensic Techniques, Fourth Edition (Practical Aspects of Criminal and Forensic Investigations)

Average customer rating:

all in one
FORMER NYPD COP DOES GOOD.
A Morbid Classic!
practical, detailed and helpful
Practical Homicide Investigation, Fourth Edition

Practical Homicide Investigation: Tactics, Procedures, and Forensic Techniques, Fourth Edition (Practical Aspects of Criminal and Forensic Investigations)
Vernon J. Geberth
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 0849333032

Book Description

Renowned for being THE definitive source of homicide investigation, Practical Homicide Investigation: Tactics, Procedures, and Forensic Techniques is the recognized protocol used by investigative divisions of major police departments throughout the world. It is also the text used in most police academies, including the prestigious FBI Academy in Quantico, Virginia. It emphasizes essential procedures, combines detailed techniques with instructive case studies, and outlines the foundation on which to build a solid, prosecutable case. The fundamental criminal investigative techniques stressed in the Fourth Edition are crucial for effective inquiry into sudden and violent death. Eminent author, lecturer, consultant, and expert witness Vernon J. Geberth begins the book with a comprehensive discussion of homicide crime scenes. The book evolves chronologically from initial police notification, the correct police response that follows, and the subsequent steps necessary to conduct an intelligent investigation. It then delves into more technical aspects of homicide investigation, augmented with numerous pictures and full-color illustrations that involve pertinent case histories. The book features two new chapters along with major revisions of those from the previous edition. In addition it contains 675 photos and illustrations - including 300 new entries that incorporate depictions of wound structures and procedures that portray exactly what to do and how to do it. All illustrations are presented in full color, including new medical-legal drawings for instruction and courtroom testimony.

Customer Reviews:

all in one.......2007-08-10

although the author has a fixation for weird sex deaths and spends more time then they are worth for an investigator in most areas, this is the best overall book i have seen for laying out a thorough investigation and peripheral issues. i wish more law enforcement officers used this book--rank, too--rank on a scene or in front of a camera can be like a bull in a china shop.

FORMER NYPD COP DOES GOOD........2007-03-15

Vernon brings many years of experience to us all in his book so that we do not make the mistakes others have made.

A Morbid Classic!.......2006-12-03

Talk about a disturbing book. This one will probably give you nightmares if you haven't desensitized yourself to violence yet. If your denial mechanism is in disrepair, you'd probably be best to avoid this book which is the "Bible" of crime scene investigation techniques. Extremely graphic photographs of murder and suicide victims along with a compelling forensic text with such chapters as 'The Homicide Crime Scene Search,' 'Estimating Time Of Death,' 'Modes Of Death,' 'Suicide Investigation,' and 'The Autopsy' makes this one of the most informative and disturbing books available. Highly Recommended!

practical, detailed and helpful.......2006-08-29

In this appropriately named "Checklist and Field Guide" Vernon J. Geberth distills the complexities of criminal investigation into a series of helpful checklists and charts. The reading is informative (though not always engaging) and he provides a necessary resource for law enforcement personnel as well as a helpful guide for authors writing books involving criminal investigation or police procedures.

Practical Homicide Investigation, Fourth Edition.......2006-07-06

Book Review: Practical Homicide Investigation, Fourth Edition
Author: Vernon J. Geberth, CRC Press, 2006

The latest edition of Practical Homicide Investigation, starts with reemphasizing the basics of homicide investigation, expands upon the coverage of practical methods of solving your murder cases and adds new information that addresses some of the newest, most crucial innovations of homicide investigation that will help us in our pursuit of justice for the victims and their surviving families. Even if you have memorized the first three editions, the 4th Edition of Practical Homicide Investigation needs to be on your "must read" list if you want to be an effective murder cop.

The textbook opens with the five components of practical homicide investigation and demonstrates the investigative strategies to be a successful homicide investigator. The addition of the color photographs to the 4th edition is a great compliment to the text, especially the coverage of wound structures and crime scenes. The images will help any investigator recognize and evaluate the potential significance of various wounds that you will encounter as a homicide investigator.

In this business, we all recognize the impact of DNA technology in our cases. The new chapter on DNA technology explains the science in a manner that murder cops can understand and utilize when evaluating homicides and the evidence associated with the cases. Being able to evaluate and understand the importance of this evolving forensic field can save you time as an investigator, prioritize the analysis requests for your forensic examiners to avoid delays due to examination requests backlogs and possibly save the lives of future potential victims as well.

The new chapter on equivocal death investigation is another worthwhile addition to the homicide investigator's bible. The fact that the deaths are equivocal means that the homicide investigator must use advanced tactics in reviewing the circumstances surrounding the deaths. The case studies in this chapter demonstrate the importance of evaluating all of the components of practical homicide investigation to ensure that wrongful deaths are not overlooked.

My favorite chapter in this latest edition of Practical Homicide Investigation is the chapter on Profiling and Investigative Assessment. The expanded coverage in this chapter reinforces the importance of behavioral evidence at the crime scene and how to utilize the collection of this "intangible" evidence in your overall homicide investigation.

The new Practical Homicide Investigation textbook could be called "4th Addition" rather than "4th Edition" as you will see when you read it. You will find newly added cases and updated information throughout the pages from cover to cover.

When you finish reading the last chapter of the 4th Edition and think that you have finished the textbook, you flip the page and find a newly revised glossary of the terms and definitions related to homicide investigations. This glossary is not only a great resource for your understanding of the terminology, but will enhance your ability to properly document your investigation in professional, well-written reports. Another important benefit of the glossary will be recognized after the arrest of the perpetrator(s) when it is your time to testify. You will be able to discuss your case in a manner that will demonstrate to the people in the judicial system, especially the jury, your dedication to your profession and to the victims of crimes. Reading and understanding this book will give you the confidence to ensure that homicide victims will get what they deserve - a thorough investigation by a professional, dedicated investigator.

I have been a PHI disciple for many years and as I read the 4th Edition text, I could hear the words of Vernon Geberth, "Follow every lead to its ultimate conclusion." - "All murder cops are cold case detectives." - "Remember, do it right the first time. You only get one chance." These directives will act as cues to keep you focused as you investigate any death cases.

All of the great additions to the 4th Edition of Practical Homicide Investigation lead to the most remarkable point of all which is that Lt. Commander Geberth took the time to improve his book for us. It demonstrates his perpetual passion for the profession of homicide investigation and is why he is known internationally as "Mr. Murder." Even though the author's name is followed by the word "retired" in parenthesis, the truth is that Vernon Geberth may have retired from NYPD, but he has never retired from the business of being a murder cop. The fact that he continues to revise the Practical Homicide Investigation textbook is a testament to his dedication to solving homicides and an example that all of us in the business should strive to achieve.

Larry Thomas. Assistant Director, Kansas Bureau of Investigation
KBI Special Agent in Charge - BTK Serial Killer Task Force

The Cell: A Molecular Approach, Fourth Edition

Average customer rating:

A Very Good Reference for a Host of Areas of Biology
Very good condition

The Cell: A Molecular Approach, Fourth Edition
Geoffrey M. Cooper , and Robert E. Hausman
Manufacturer: Sinauer Associates, Inc.
ProductGroup: Book
Binding: Hardcover

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ASIN: 0878932194

Book Description

Courses in molecular and cellular biology are a cornerstone of undergraduate programs in the life sciences. The material is not only fundamental to all of biology, but also represents an exciting and rapidly moving area of science. This makes teaching undergraduates a rewarding experience, but also a challenging task. The Cell: A Molecular Approach meets this challenge by providing students with not only the most current information, but also with a conceptual framework and an introduction to the experimental nature of contemporary research. Designed for use in one-semester introductory cell biology courses, The Cell presents current comprehensive science in a readable and cohesive text that students can master in the course of one semester.

The new Fourth Edition of The Cell has been updated to reflect major advances since publication of the Third Edition in 2003, including:

* The role of microRNAs in regulation of gene expression
* Expanded discussions of genomics, proteomics, and signaling networks
* Translational regulation and the mTOR signaling pathway
* Roles of specialized lipid domains in cell surface processes
* Advances in stem cell biology
* Oncogenes and the rational design of new anticancer drugs

While retaining the overall organization, themes, and special features of earlier editions, including Key Experiment and Molecular Medicine essays, the Fourth Edition of The Cell includes:

* Three additional chapters, including Cell Death and Cell Renewal
* Major new sections, including
o Proteomics: Large-Scale Analysis of Cell Proteins
o Bioinformatics and Systems Biology
o Cell-Matrix Interactions
o Signaling Networks
* New chapter sidebars that highlight areas of interest and clinical applications throughout each chapter
* New margin elements that refer students to animations and activities on the Companion Website
* Revised end-of-chapter questions, with answers for all questions included in the back of the boo

Customer Reviews:

A Very Good Reference for a Host of Areas of Biology.......2007-07-07

This is a textbook for undergraduates, but I'm not a student. I've been studying evolution from a variety of books and I finally decided I needed a systematic look at the biology of the cell. I shopped Amazon and decided on this book and I am well satisfied with it.

There is too much information for me to summarize, but the book's Table of Contents does an excellent job of that. (Click on "Search inside this book".) The book also has an abbreviated Table of Contents, not shown in this product page, which will help the reader locate a particular topic within the longer ToC.

The book starts with "Introduction", which provides background material and gives a glimpse of the book ahead. I think that a student using this as the text for a course for a one-semester course will probably need to know most of this beforehand. A person with more time will still need some background. You should already know what carbohydrates, amino acids, lipids, and nucleic acids are; the basics of the DNA-to-RNA-to-protein pathway; the fact that a membrane consists of a double layer of phospholipids, with other molecules embedded in it; and other basics of the cell. You will need at least a modest familiarity with diagrams of molecules and molecular processes. If the Table of Contents doesn't look like nonsense to you, you're probably prepared.

The exercises are important because they contain material that is not in the main text. For example, there are exercises that ask you to apply what you learned in the text to a problem similar to the ones scientists try to solve. It is doubly important for non-students because they let you verify your learning.

The Book Description says this book has "the most current information". This isn't possible in a book; in a field as active as cellular and molecular biology a lot happens between the time the manuscript is completed and the time the book is released for sale. What this book can do is to give you the background you need to read the science news articles. And that's doing quite a bit.

I mentioned that I had been reading other material wanted to fill in my background. The other material included such topics as molecular biology of the gene, signal transduction, mitochondria, and cancer. Since the cell is the basic unit of biology, The Cell is a gateway to many other topics as well. It would have been easier if I had read The Cell first, but I didn't know that. If you might be interested in some of the earlier books, they are listed in my Listmania "Natural Processes That Promote Evolution". There is a link to it in my Amazon Profile. (Click on my name at the top of this review.) But, of course, I recommend reading The Cell first.

If you're a student wondering what kind of nut reads books like this for fun, the Profile also has a bit about me under the title "In My Own Words".

I finished The Cell a few weeks ago and since then I have referred to it a few times for help in understanding science news. Given that I found it useful, there must be plenty of other people who would, and so I wrote this review.

Very good condition.......2007-03-09

The book was in very good condition and was received in a timely fashion.

AIDS: Science and Society, Fourth Edition (Jones and Bartlett Series in Biology)

Average customer rating:

A book that is continuously updated
Great for anyone!

AIDS: Science and Society, Fourth Edition (Jones and Bartlett Series in Biology)
Hung Fan
Manufacturer: Jones and Bartlett Publishers, Inc.
ProductGroup: Book
Binding: Paperback

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ASIN: 076370086X

Book Description

The use of understandable vocabulary, clear illustrations, and up-to-date information allows non-specialists to fully grasp the biological, social, and psychological aspects of this disease.

Customer Reviews:

A book that is continuously updated.......2005-01-27

An amazing book. I came to know it by being a student in the class that the authors teach at UC Irvine--AIDS Fundamentals (by far the most informative and interesting class I have ever taken). I read the second edition, originally--the great thing about this book is that it is consistantly updated textbook--if you read each edition as it appears, you keep up with the developments. This is a book to be read over and over.

Great for anyone!.......2001-06-20

This book is a must-have for anyone who works in health education or is a practitioner of any sort. Fan et al have created an easy-to-read yet detailed account of HIV and AIDS from the views of the epidemiologist, virologist, health care worker, psychologist, sociologist, and anyone else interested in the topic. I first encountered this book in 1999 as a student enrolled in a course on HIV and it's impact on our society. I now use it in teaching County sponsored HIV/STD workshops and mini courses to youth ages 13-19 and to professors and students at my university.

Essentials of Molecular Biology, Fourth Edition

Average customer rating:

A Disappointing Introduction to a Fascinating Subject
It is to molecular biologists what DNA is to cell.

Essentials of Molecular Biology, Fourth Edition
George Malacinski
Manufacturer: Jones and Bartlett Publishers, Inc.
ProductGroup: Book
Binding: Hardcover

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ASIN: 0763721336

Book Description

This revision retains its focus on the fundamental aspects of biomolecular structure and functions in a concise and student friendly manner.

Customer Reviews:

A Disappointing Introduction to a Fascinating Subject.......2003-04-20

Unfortunately, I could not disagree with my fellow reviewer more...

I was introduced to this text while a student in Dr. Malacinski's own molecular biology class at Indiana University. While I learned a great deal from the class itself, I found this book to be utterly disappointing in more ways than one. While he is undoubtedly a great teacher, Dr. Malacinski is a terrible author. His explanations of even the simplest concepts are confusing at best and downright confounding at their worst. Often, the book uses long, languid syntax to explain basic ideas, and in doing so, loses track of the fundamental basis of the concepts it is trying to elucidate. It seems to me as though Dr. Malacinski's purpose in writing an introductory textbook would be better served by offering his readers short, direct, and to-the-point explanations (such as those offered in the "Student Companion.") The trichromatic layout of all the book's diagrams make their interpretation difficult, and do little to provide the reader with relief from the bland nature of the prose. The text's lack of detailed color photographs is equally maddening - more than once when attempting to study one of the book's photographs, I felt as though I were staring at a "magic eye" collage rather than an electron micrograph. Additionally, Dr. Malacinski's attempts of to interject his personal opinions and imbibe his readers with enthusiasm for the subjects being treated feel trite and unnecessary. The text skims over many fundamental issues relevant to the study of molecular biology - most notably in its almost non-existent coverage of proteins and their role in molecular biology. I was equally disappointed in the book's total lack of coverage (or even introduction to) more advanced concepts in the field, particularly eukaryotic molecular biology. Although aptly titled "Essentials of Molecular Biology," students intending to pursue more advanced studies in the fields of biochemistry and molecular/cell biology will be poorly served by the book's complete omission of these advanced concepts. Altogether, while this book is one of the few molecular biology textbooks specifically designed for use in a one-semester undergraduate introductory course, many of the "more advanced" textbooks available provide a more comprehensive and easily understandable treatment of the material covered in this text. To those with a sincere interest in learning about both the concepts and breadth of molecular biology, I recommend "Molecular Biology of the Cell" (4th ed.) by Alberts et al, "Molecular Cell Biology" (4th ed.) by Lodish et al, and "Biochemistry" (5th ed.) by Berg and Stryer as alternatives to this book.

It is to molecular biologists what DNA is to cell........1999-09-13

I read this book at the library and was highly impressed with the mode of explaination and representation. The book is highly informative giving the explaination with the best lucid way and the figures too are at the right places. How so ever the book would have been still more better if the method given at many places would have been clubbed with the major draw backs and precautionary steps.

All in one it is a very useful book to be obtained by the biologists working on the field

Book Description

Thoroughly updated and in a new two-color format, this well- respected text presents the fundamentals of biochemistry and related topics to students pursuing a one- or two-semester course in pre-med biochemistry or medical programs. The second edition is equally applicable to other health-related fields such as clinical chemistry, medical technology or pharmacology. Medical Biochemistry, Fourth Edition, focuses on the foundations and clinically relevant applications of normal human biochemistry and pathology. Abundantly illustrated with four-color plates.

Revised chapters on molecular biology reflect the latest research in the field
Two color throughout with four color plates
Reference quality appendices include practical information on clinical lab parameters used to diagnose a range of diseases

Essentials of Conservation Biology, Fourth Edition

Average customer rating:

Thought-provoking, but muddled

Essentials of Conservation Biology, Fourth Edition
Richard B. Primack
Manufacturer: Sinauer Associates, Inc.
ProductGroup: Book
Binding: Hardcover

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ASIN: 087893720X

Book Description

The current widespread loss of species, genetic variability, and even entire biological communities has caused serious concern within the scientific community and among the general public. The new multidisciplinary science, conservation biology, has developed to address this crisis, and both research activity and student interest in conservation biology have rapidly expanded during the last fifteen years. The excitement of this field is highlighted by 2001-2002 being designated as the International Biodiversity Year by DIVERSITAS, a scientific body associated with the United Nations. Richard Primack's Essentials of Conservation Biology was the first textbook in this field, and continues to be widely used in undergraduate courses. Essentials of Conservation Biology, Third Edition, is an updated and improved version of the popular first and second editions, and includes current examples, study questions, and the latest literature.

Essentials of Conservation Biology combines theory and applied and basic research to explain the connections between conservation biology and environmental economics, ethics, law, and the social sciences. This new edition stresses the need for theory, research, and an interdisciplinary approach in solving conservation problems. A major theme throughout the book is the active role that local people, the general public, conservation organizations, and governments can play in protecting biological diversity. An additional theme is sustainable development: providing for human needs in a way that does not harm biological diversity. Dr. Primack presents positive suggestions throughout the book to show the reader how threats to species are being dealt with, and conveys an enthusiasm for the exciting new developments in the field of conservation biology.

Essentials of Conservation Biology, Third Edition, is divided into 6 parts and contains 22 chapters. Each chapter begins with general ideas and principles, which are illustrated with choice examples from the current literature. The most instructive examples are discussed in boxes highlighting species and issues of particular significance, such as the decline of songbird populations, conservation programs on military reservations, the pressures for development in wildlife refuges, sea turtle conservation, and the restoration of river ecosystems. Chapters end with summaries, an annotated list of suggested readings, and discussion questions. The first three chapters (Part I) define biological diversity and give general background information in ecology, evolution, and biogeography. Part II outlines the economic and ethical arguments for preserving biological diversity. Part III describes the rapid loss of species currently occurring, and the major threats to species. Part IV discusses the problems faced by small populations in the wild and in captivity, and the information needed to protect species. Part V reviews the range of strategies for protecting biological diversity in the wild, both inside and outside protected areas. The establishment, design, and management of protected areas are emphasized. Part VI describes the legal, financial, and political mechanisms that exist for the protection of biological diversity at local, national, and international levels. The book closes with a strong agenda describing the changes needed to protect biological diversity, and the roles that conservation biologists need to play to make those changes a reality.

Essentials of Conservation Biology, Third Edition, is beautifully illustrated and is written in clear, non-technical language. It is suitable for undergraduate biology students, as well as students in other disciplines. The book is particularly appropriate for students who do not speak English as a first language. The book's broad, up-to-date coverage and its extensive bibliography with over 1,000 references also make it valuable to graduate students and researchers.

Customer Reviews:

Thought-provoking, but muddled.......2005-12-28

This was the primary textbook for a graduate conservation biology course I had. I found the book to be an enjoyable read and thought-provoking. However, the book's organization was at time muddled. A decent introduction to the field of conservation biology, but as a textbook, it falls short.

Principles of Molecular Virology (Standard Edition), Fourth Edition

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Principles of Molecular Virology (Standard Edition), Fourth Edition
Alan J. Cann
Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0120887878

Book Description

Principles of Molecular Virology, Fourth Edition provides an essential introduction to modern virology in a clear and concise manner. It is a highly enjoyable and readable text with numerous illustrations that enhance the reader's understanding of important principles.

* New material on virus structure, virus evolution, zoonoses, bushmeat, SARS and bioterrorism
* Standard version includes CD-ROM with FLASH animations, virtual interactive tutorials and experiments, self-assessment questions, useful online resources, along with the glossary, classification of subcellular infectious agents and history of virology

The Cytokine Handbook, Fourth Edition, Two Volume Set

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The Cytokine Handbook

The Cytokine Handbook, Fourth Edition, Two Volume Set

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0126896631

Book Description

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses.
Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.

Key Features
* Covers all main cytokines and chemokines
* Written by experts
* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome
* The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters
* Includes major emphasis on clinical applications
* Extensively illustrated with tables and figures

Customer Reviews:

The Cytokine Handbook.......2000-08-19

This book covers most of the information for people who is interested in cytokine research. The content is detailed enough for professionals who is actually working in the area of cell signaling or drug discovery. It may not be a good starting point for amateur readers.

Cytometry: New Developments, Volume 75, Fourth Edition (Methods in Cell Biology)

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Cytometry: New Developments, Volume 75, Fourth Edition (Methods in Cell Biology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0125641702

Book Description

The chapters in CYTOMETRY MCB volumes, including this 4th Edition, provide comprehensive description of particular cytometric methods and review their applications. Some chapters also describe new instrumentation and provide fundamental information on use of new fluorescent probes and on data analysis. Although the term "edition" suggests the update of earlier volumes, in fact, nearly all chapters of the 4th Edition are devoted to new topics. The authors were invited to present not only technical protocols, such as available in other methodology books that specialize in the protocol format, but also to discuss the aspects of the methodology that generally are not included in the protocols. Many chapters, thus, present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical setting, common traps and pitfalls, problems with data interpretation, comparison with alternative assays, choice of the optimal assay, etc. Some chapters review applications of cytometry and complementary methodologies to particular biological problems or clinical tasks.

The 34 chapters presented in CYTOMETRY 4th Edition cover a wide range of diverse topics. Several chapters describe progress in technology of fluorescence measurement. The novel phenomenon of the surface-plasmon coupled emission (SPCE) presented in one of these chapters, in combination with nanophotonic technology, is expected to open entirely new possibilities for ultra-sensitive detection of fluorescence, likely from single fluorochrome molecules. The chapter on cytometry of fluorescence resonance energy transfer (FRET) describes the theoretical foundations- and uncovers further analytical possibilities- of this methodology. The chapter on fluorescent proteins is an exhaustive review of accomplishments and possibilities offered in this rapidly expanding field. The critical assessment of quantitative analytical capabilities of confocal microscopy, optimization of emission optics and further progress in development of laser scanning cytometry instrumentation are the topics of other chapters focused on methodology of fluorescence measurement.

Another group of chapters describe variety of cytometric methods and their applications in studies of cell death, particularly by mode of apoptosis, mechanism of antitumor drug action, and DNA damage. The rapidly growing application of cytometry in phytoplankton is also assessed in great detail. The chapters on biohazard sorting and data analysis guidelines will be of interest to a variety of researchers in different fields.

Cell immunophenotyping represents the most common application of cytometry, particularly in clinical setting. It is not surprising, therefore, that over a third of all chapters of this volume are devoted to methods and applications of multi-color immunophenotyping and probing immune functions of lymphocytes and phagocytes.

The field of cytogenetics and molecular genetics is represented by several chapters. Presented are the methods for telomere length measurement and genomic array technology as well as multiplex amplifiable probe hybridization (MAPH) and multiplex ligation dependent probe amplification (MLPA), the latter to probe the copy number changes (deletions, multiplications) in genomic DNA. A very exhaustive is the chapter describing the use of subtelometric probes in studies of mental retardation.

In tradition with the earlier CYTOMETRY editions, the chapters were prepared by the researchers who either developed the described methods, contributed to their modification, or found new applications and have extensive experience in their use. The list of authors, thus, is a continuation of "Who's Who" directory in the field of cytometry.

* Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays
* Discusses many new assays developed since the previous edition
* Presents recent developments in cytometric intrumentation/technology

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