Book Description
The long-awaited new edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline, giving both historical and basic chemical context.
Divided into four parts: Genetics and Chemistry, Central Dogma, Regulation, and Methods.
For college instructors, students, and anyone interested in molecular biology and genetics.
Customer Reviews:
Am Studying for the Biochemistry GRE - This book is golden.......2006-09-19
I got this book to assist for my prep for the Biochemistry GRE - I know a lot about Biology. So this is a great Book - First, It is very readable - I was surprised I was not able to put it down and knocked off 100 pages in record time. Besided that - it is enjoyable and not dull and boring - Second, The great experiments are given and insight into the science reasoning behind them also. This book makes the discover of genetics, DNA, RNA and protein building come alive. Third, this book is very current with research and cites the papers and journals where the important biology, Genetic, molecular & cell biology was published. That alone would save you the time to research and site these for your own research. Lastly, the pictures and recollections of the experimenters and "who knew who" are a total hoot.
Great Book.......2006-03-18
This book is an awesome teaching guide but the real prize goes to the CD and animations. Where a subject might be a bit hazy in the text, the flash animations on the CD are clear and concise.
Good book.......2005-11-05
Some books are just very well written-this is one of them!
I like that they leave space in the margin to write notes. Organized more like a book you can read in chapters compared to the Lewin Genes text. Concise and up to date.
Good disc included with lots of great animations.
Don't buy this book.......2005-09-24
Buy this book if you are really unintelligent and knows virtually nothing about biology. Really. if you are the person who wants to learn, find an alternative book.
Readable and Thorough, An Excellent Reference.......2005-07-13
I am a layman with a serious interest in biology. I read science news, especially in Nature and Scientific American, and I often find that I don't have enough background to understand articles at the level at which I want to understand them. I bought this book hoping to get that background, and I wasn't disappointed.
For example, once the human genome was sequenced, it appeared that there were far too few genes for an organism as complex as ourselves. But investigation shows that most genes occur in segments and that the messenger RNA must be cut and spliced before the protein can be formed. Often there are two or more ways the RNA may be spliced, so that one gene can specify more than one protein. Another problem is that the genome seemed to consist mostly of sections that don't code for proteins; these were called "junk". But it turns out that some "junk" DNA codes for RNA sequences that have catalytic and regulatory roles, roles which used to be considered the bailiwick of proteins alone. Articles about topics such as these used to confuse me thoroughly, but after reading this book I find them much clearer.
This book benefits from a great many illustrations and I recommend that you go through each one as you would a worked problem in a math text. Observe how the pieces fit together, how a particular group of atoms enhances or inhibits a reaction. The practice will help you to understand other things you will read later.
I called this a "reference" for good reason: I assume that I will come across many future articles which will send me back to it to fill in some background.
[Added 4 July 2006] As I assumed when I first wrote this review, I have used it for reference. I have read several books about what I call "enhanced evolution", where mechanisms that go beyond simple point mutations speed up evolution by providing more variation. For example, gene regulation, alternate splicing, and gene duplication all play important roles. I have surprised myself by remembering more than I expected to (thanks to the clarity of this book) but I have still used it for clarification.
Amazon.com
Inheriting the mantle of revolutionary biologist from Darwin, Watson, and Crick, Richard Dawkins forced an enormous change in the way we see ourselves and the world with the publication of The Selfish Gene. Suppose, instead of thinking about organisms using genes to reproduce themselves, as we had since Mendel's work was rediscovered, we turn it around and imagine that "our" genes build and maintain us in order to make more genes. That simple reversal seems to answer many puzzlers which had stumped scientists for years, and we haven't thought of evolution in the same way since.
Why are there miles and miles of "unused" DNA within each of our bodies? Why should a bee give up its own chance to reproduce to help raise her sisters and brothers? With a prophet's clarity, Dawkins told us the answers from the perspective of molecules competing for limited space and resources to produce more of their own kind. Drawing fascinating examples from every field of biology, he paved the way for a serious re-evaluation of evolution. He also introduced the concept of self-reproducing ideas, or memes, which (seemingly) use humans exclusively for their propagation. If we are puppets, he says, at least we can try to understand our strings. --Rob Lightner
Book Description
The million copy international bestseller, critically acclaimed and translated into over 25 languages. This 30th anniversary edition includes a new introduction from the author as well as the original prefaces and foreword, and extracts from early reviews. As relevant and influential today as when it was first published, The Selfish Gene has become a classic exposition of evolutionary thought. Professor Dawkins articulates a gene's eye view of evolution - a view giving centre stage to these persistent units of information, and in which organisms can be seen as vehicles for their replication. This imaginative, powerful, and stylistically brilliant work not only brought the insights of Neo-Darwinism to a wide audience, but galvanized the biology community, generating much debate and stimulating whole new areas of research.
Customer Reviews:
Excellent overview of evolution.......2007-10-08
Scholars pro-evolution can generally be divided into 1) those who believe in evolution at the group level (ie: The reason lions behave in a particular way is because they want to survive as a species) or 2) those who believe in evolution at an individual level (ie: The reason a particular bird behaves in a particular way is because he wants to survive as an individual bird). Dawkins' views are closer to the latter. In fact, he takes it a step further and argues for evolution at the gene level. I think he makes a very convincing case for his views. Of course nothing is certain (except uncertainty perhaps) so he does not prove his theory definitively.
The book can be hard to read at times and may be a bit slow for those with no background in biology or science. Nevertheless I think anyone with patience can read, enjoy and learn from this important book.
No matter what your views this is a very educational and important book. Highly recommended.
Fancifully Dark.......2007-09-21
In his play "Suddenly, Last Summer," Tennessee Williams writes of a young man who, on vacation at the seashore, watches newly hatched baby turtles struggling down to the safety of the water. Only a small percentage get there, though, because the gulls overhead scoop them up and eat them faster than they can crawl. The young man, observing this and already under great psychic tension, tells his cousin that now "I have seen God!" Later on, we realize the man is morally insane, and that perhaps this was the turning point; his descent into insanity.
Whether Williams himself thought of God the same way, I don't know. But certainly the example of the turtles and gulls had been chosen, out of thousands of other such biological observations, because the young man chose to find God - or truth - in it. He could, if he had been in a sunnier mood, chosen to look at nesting robins or a mare and her colt.
In "The Selfish Gene," Dr. Dawkins argues against the idea of altruism in nature: mothers take care of their young because they love them, etc. Dawkins says they do it because it's in their genes. But he takes it one step further: he says it's the genes themselves that are struggling to survive - not the whole animal. The analogy of genes "using" animal bodies for their own "selfish" ends, as if we were robots and the genes our drivers, is made over and over again.
Of course, Dawkins realizes this is not correct. Darwinism asserts that biological life came into existence blindly: cells and animals came (and continue to come) into being, not because they chose to, but because of natural selection. And the ones who survive do so because of serendipity.
This is a very hard concept, of course, to understand. I remember Sister Pauline laboring to explain to us girls in junior biology class that the white butterflies didn't decide to turn black; they turned black over generations, due to natural selection. She had a hard time of it. (Catholics are "allowed" to choose between a literal or analogous interpretation of the Bible, so she was not breaking any official rules!)
In other words, a "selfish" gene (or animal) makes no more sense in Darwinistic terms than an "altruistic" one.
Dawkins explicitly states this on page 196. But he uses the selfish gene analogy so many more times - hundreds of times - that, just from the sheer repetitiveness of the theme, it may sink in too deeply (and do some psychic damage) to people who are not currently living on the sunny side of the street, so to speak.
For those people, like the gentleman who wrote the touching review of how this book contributed to fits of depression, I'd say: This point of view has no more legitimacy than the altrustic point of view.
An additional (and, I think, unnecessary) weight on the sensitive reader's soul is the aspersions that Dr. Dawkins, an aggressive atheist, throws on the concept of God - limited mainly, I think, to his chapter on memes (he saves most of his vituperation on this issue for another book, "The God Delusion").
On that score, I'd say: please realize that scientists don't know everything. People in different professions develop different mental prejudices: lawyers think like lawyers, engineers like engineers, etc. And scientists, for whom scientific method is everything, tend to think that anything that's not measurable therefore doesn't exist. This is a logical fallacy. They also tend to think they are so intelligent, and the world outside science is so simple, that they can read a few survey books on religion, philosophy, or history and know all there is to know about the field. This leads them to made irresponsible, blanket statements, completely unaware of how little they know.
On page 201, he winds up a chapter by saying all is not gloomy; humans can still strive towards altruism; that "[w]e, alone on earth, can rebel against the tyranny of the selfish replicators." Then, in a long footnote, he writes that some of his colleagues disapproved of this passionate summation. "In some cases, the criticism came from doctrinaire sociobiologists jealously protective of genetic influence...." and in others, from "high priests of the left jealously protective of a favorite demonological icon!" (His exclamation point.) These latter, apparently, were objecting that he on the one hand implied a belief in free will while on the other hand talking like a genetic determinist. He objects to this, saying, if I understand it, that he's both, and ends the argument by saying, "We, that is our brains, are separate and independent enough from our genes to rebel against them. ...[W]e do so in a small way every time we use contraception."
Now, I don't pretend to have a handle on the philosophical and sociobiological arguments regarding whether or not humans have free will, or even what exactly free will is. But in the above I don't see that Dr. Dawkins really does, either: he treats it far too simply.
In sum, read the book, but don't let it get you down. After all, if the village priest doesn't have the right to bully people intellectually, than neither does the research scientist.
Mandatory reading for students/interested persons.......2007-09-17
This is an excellent primer to biological evolution and could also be a valuable co-text with a standard high school biology course. Written in British english, it is quite understandable though more academic than casual.
Dawkins' use of the 'gene's eye view' of the world permeates the text. It is very easy to follow. A great book to rebut any creationist's
viewpoint. This was Dawkins' first book in the field. It will not disappoint or talk down to you.
Enjoy.
a mixed bag.......2007-09-09
Parts of the book were utterly fascinating to me, such as the groundbreaking idea of the "meme" as a unit of cultural transmission. But the argument that species are survival machines for our "immortal genes" seems seriously flawed.
First and foremost in my mind, it is hard for me to swallow that organisms practice altruism because the gene or genes that are responsible for this altruism have a probability of existing in the recipient of the altruism, the probability increasing with the closeness of familial relatedness. How, then, to explain altruism beyond the family, or even beyond the species? The author mentions that there is at least one well-documented case of a dolphin rescuing a drowning human being. In the book this was suggested to be a mistake. One of Earth's most intelligent animals has a gene for rescuing long, narrow objects and cannot tell the difference between a human and its own species. I got doubtful when contradictory evidence was explained as a mistake. And what about organisms' adopting children originating from other parents? Always a mistake? Highly expensive practice for when the real deal arises?
I do not understand why there must be *a* unit of natural selection. Can't there be more than one, sometimes at odds with each other, sometimes in tandem? I do believe genes are selected over other genes, but I believe groups can be selected over other groups, too. Perhaps other units, both larger and smaller than genes (Why not the selfish base pair?), are also naturally selected.
Finally, especially considering recent discoveries in genomics that have downsized the number of estimated human genes, there cannot be one gene behind any behavioral trait you can think of, a gene for being nice to your cousin, for example. I get that a gene can have many functions and can have a net effect of being nice to your cousin, and in its absence you would be less nice to your cousin, but this makes for a complicated web which would get torn apart as succeeding generations inherit just part of the web. The influences of biology, environment, and history get harder to ignore.
a new way to look at the world.......2007-08-29
Dawkins challenges us to look at old ideas (Darwinian) in a new light. At times I found his mathematical calculations tedious to follow, however when I bothered to think them through, they did make sense. I esepcially enjoyed the chapter on game theory because it helped to explain why humans do not usually behave in blatantly exploitive ways in spite of our "selfish genes". I recommend the book to anyone who wonders how the world works.
Average customer rating:
- great
- Fascinating material
- Good introductory material for the technical
- Good overview but lacks technical rigor
|
Molecular Biotechnology: Principles and Applications of Recombinant DNA
Bernard R. Glick , and
Jack J. Pasternak
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ASIN: 1555812244 |
Book Description
Completely revised and updated, this second edition of the best-selling Molecular Biotechnology covers both the underlying scientific principles and the wide-ranging industrial, agricultural, pharmaceutical, and biomedical applications of recombinant DNA technology. This new edition includes expanded coverage of the types of organisms and cells used in molecular biotechnology, DNA, RNA, and protein synthesis, the methodology and applications of genetic engineering of plants, and microbial production of therapeutic agents. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. TABLE OF CONTENTS: Fundamentals of Molecular Biotechnology The Molecular Biotechnology Revolution Molecular Biotechnology Biological Systems DNA, RNA, and Protein Synthesis Recombinant DNA Technology Chemical Synthesis, Sequencing, and Amplification of DNA Manipulation of Gene Expression in Prokaryotes Recombinant Protein Production in Eukaryotic Cells Directed Mutagenesis and Protein Engineering Molecular Biotechnology of Microbial Systems Molecular Diagnostics Microbial Production of Therapeutic Agents Vaccines Synthesis of Commercial Products by Recombinant Microorganisms Bioremediation and Biomass Utilization Plant Growth-Promoting Bacteria Microbial Insecticides Large-Scale Production of Proteins from Recombinant Microorganisms Eukaryotic Systems Genetic Engineering of Plants: Methodology Genetic Engineering of Plants: Applications Transgenic Animals Human Molecular Genetics Human Gene Therapy Regulating and Patenting Molecular Biotechnology Regulating the Use of Biotechnology Patenting Biotechnology Inventions
Customer Reviews:
great.......2007-01-04
I found the the book in a very good shape. I'm very much satisfied.
Fascinating material.......2005-06-18
I used this book for one of my favorite classes in college on biotechnology. It will show you the cool side of science and all of the neat things you can do with biology and DNA. The level is low enough to where you only need a minimal background to understand it, basic biology classes and preferably genetics. After completing the book you should be excited about the future of biotech, and you will have some understanding about how it works.
Good introductory material for the technical.......2001-05-11
To those who are interested in the functional aspects of the DNA this is the right introductory stuff. It covers areas including basic molecular biology to commercial methods for manipulating the genes. Pretty useful for someone who's more interested in the technology than the biology!
Good overview but lacks technical rigor.......2000-04-07
I am currently using this book for a course in Molecular Biotechnology taught through the chemistry department. Although the book covers a wide range of biotechnology fields, from manipulation of gene expression in prokaryotes and eukaryotes through human gene therapy, it does so in a somewhat shallow and repetitive way. I have also seen clearer and more concise diagrams covering similar topics in other biochemistry books, and there is a paucity of in-depth coverage in any particular area. This is not necessarily the authors's fault, however, arising from the plethora of information found in the biotechnology field. If someone wants a broad review of molecular biotechnology, this is a decent book, but if you want to focus on a specific area within biotechnology, look somewhere else.
Book Description
Genetics: From Genes to Genomes is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Third Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.
Customer Reviews:
Not for the uninitiated.......2007-07-07
This is a good book if you already have a foundation in genetics. Oddly, the book is marketed as your basic undergrad genetics text. Yet instead of just explaining the concepts, it leads you on the path of discovery of how researchers figured all this stuff out. If you are still learning the subject, you may do better with Klug/Cummings/Spencer. If you are going into higher levels of biology and want to learn some research methods, this is a good book.
Genetics: From Genes to Genomes.......2007-03-09
The book came in very quickly and I am very happy with the purchase.
Average customer rating:
- Forensic DNA Typing, Second Edition: Biology, Technology, and STR Markers
- Great book for learning DNA
- Clearly, an outstanding piece of work!
- The Breakthrough in Forensics This Year! - A Must Have Book!
- Marvelous work!
|
Forensic DNA Typing, Second Edition: Biology, Technology, and Genetics of STR Markers
John M. Butler
Manufacturer: Academic Press
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ASIN: 0121479528 |
Book Description
Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the finished reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testingdesirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.
*The only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome
*Chapters cover the topic from introductory level right up to "cutting edge" research
*High-profile cases are addressed throughout the book, near the sections dealing with the science or issues behind these cases
*NEW TO THIS EDITION: D.N.A. Boxes--boxed "Data, Notes & Applications" sections throughout the book offer higher levels of detail on specific questions
Customer Reviews:
Forensic DNA Typing, Second Edition: Biology, Technology, and STR Markers.......2007-08-13
I would not recommend this book to someone who was completely new to the use of genetics as a tool for forensics. I did an undergraduate degree in biotechnoloy in 2000 and wanted to review and learn more about specifically how most DNA in crime labs was being processed today. This book was recommended to me by the head of a prominent DNA crime lab. It is written at a higher level than most texts but offers a wealth of detailed information, particularly if you are interested in contrasting advantages and disadvantages of different kits and equipment.
Great book for learning DNA.......2006-11-10
This book is a great book for teaching DNA. It breaks down the information pretty good in some areas but not as well in others. Overall I would say it is a good book.
Clearly, an outstanding piece of work!.......2001-03-28
While Dr. Butler's book on DNA typing is clearly based on experience and profound understanding of the subject, I was most impressed with the readability. I was thrilled to find principles illustrated by examples from current events! Students of science will find this book refreshing. Well written (and edited)!
The Breakthrough in Forensics This Year! - A Must Have Book!.......2001-03-21
Dr. Butler takes a very complex subject and makes it easy enough for the novice to understand, yet is comprehensive enough for the professional research analyst. It is full of excellent research and observations on one of the most exciting and innovative technologies in DNA research that has been discovered in recent years. This book, without a doubt, will stand the test of time as being the authoritative reference on DNA forensic research. This book is packed with research and information that will enlighten you to the technological breakthroughs that are being made in forensic science. I have heard Dr. Butler speak and read several of his papers. He is without question the expert in DNA analysis with STR markers and this book has the distinction of being the best book ever written on the subject. Get this book, study it and find out why STR markers are the groundbreaking method for DNA analysis. If you are in any way involved with DNA research, you will find this book a desktop reference you will turn to again and again.
Marvelous work!.......2001-03-21
This book has opened my eyes to the vast world of DNA analysis. It is an invaluable resource to those who want to understand how criminal justice will advance into the new millennium. Butler's text will be the keystone of DNA analysis in the future. I look forward to revised editions as new things arise.
Customer Reviews:
Epigenetics - a timely and important text........2007-05-15
It is becoming clear that epigenetic mechanisms are responsible for a large number of "genetic" events in the organism, both under normal and pathological circumstances. This advanced text (suitable for advanced undergraduates and beginning graduate students) brings together, in a very readable way, the various mechanisms of epigenetic heredity.
An invaluable educational tool.......2007-04-11
Epigenetics is a scientific textbook written to teach advanced undergraduate and graduate college students about epigenetic mechanisms, which regulate gene expression in many biological processes. Chapters cover histone modifications, chromatin remodeling, DNA methylation, siRNAs and gene silencing, X-chromosome inactivation, epigenetics in microbes, plants, insects and mammals, and much more. An in-depth, scholarly, and informative instructional reference, interspersed with occasional color photographs and diagrams, featuring an extensive list of references and a general summary at the end of each chapter to aid comprehension. An invaluable educational tool for specialized college science courses, as well as for professionals in the field of biology seeking to sharpen their understanding of modern epigenetics.
Represents the Current State of the Art.......2006-12-19
Wikipedia says: 'Epigenetics is the study of epigenetic inheritance, a set of reversible heritable changes in gene function or other cell phenotype that occur without a change in DNA sequence (genotype).'
That's a pretty general definition, and you can get into some pretty good arguments that this or that word should be changed.
The fundamental discoveries that began the field began to be discussed in 1941, but it grew slowly until fairly recent years. By 2004 the science had developed enough that the 69th Cold Spring Harbor Symposium on Quantitative Biology covered the topic. Many of the authors of this book attended that symposium and the seeds for this book were sown.
The book was written by about forty of the preeminent researchers in the field. It consists of 24 chapters covering virtually all known aspects of the subject. It can serve as a reference work for the current state of the art, or could be used as a text for advanced undergraduate or graduate courses on gene regulation.
Customer Reviews:
Excellent Intro and More.......2007-07-08
This is extremely well written introducton for undergraduates. I am using it as the backup since my instructor assigned Harwell et al's book, which is not nearly as well written. This book has excellent graphics, the whole book is well organized and well written.
great book, concise.......2007-01-18
This book covers genetics quite well its concise. It covers all the topics pretty well and also has plenty of genetic problems to make sure you know your stuff. I'd recommend getting the solutions book as well
decent book - satisfactory genetic text.......2005-10-28
My class didn't use this text much as part of the course but when i read it i found it helpful - the reviews were well done and outlines helped cover the material.
I used this book for my lectures........2004-07-21
OK, let me put it simply.
I used this book to prepare for my lectures to 2nd year medical undergraduates- and I received outstanding feedback. The students just loved it!
A descent book for beginners.......2004-02-08
Before making any critics about this book I should stress upon the fact that the authors well deserve a four star rating for this most readable book, both for the writing style and for the contents. Almost everything written is clear, concise and well presented. The captions are of high quality and if you ever buy this book feel sure that you are not wasting your money! I am referring in particular to chapter 16: Genetics of Bacteria and Bacteriophages which in reality is quite tricky but here presented with simple words. You may not have to read it more than once for you will understand it right from the first lecture. For in-depth study though you might need something more advanced!
However I did not really appreciate the way the fluctuation test of S.Luria and M.Delbruk was presented nor was the following work of J.Cairns and B.Hall in chapter 14: Gene mutation, DNA repair and Transposable elements. There seems to lack the true essence of it. Furthermore the existence of mutational hotspots is limited to a subsection only of chapter 14 and a few lines on the work of S.Benzer. Even B.Lewin in Genes VII gives a better treatment of mutational hotspots. Finally I would have expected a chapter on Mutations to talk about mutator mutations as possible ways to increase or decrease the spontaneous mutation rate but no such references were made.
Despite these few things, if you love genetics or need an introductory course be sure that this book is meant for you!
Average customer rating:
- A good introduction to the topic
- Well written, short explanations but nevertheless understandable
|
Microarray Gene Expression Data Analysis: A Beginner's Guide
Helen Causton ,
John Quackenbush , and
Alvis Brazma
Manufacturer: Blackwell Publishing Limited
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ASIN: 1405106824 |
Book Description
Microarray technology is arguably the most important recent breakthrough in molecular biology. It enables researchers to obtain snapshots of gene expression for all the genes in a genome in a single experiment. Microarray experiments generate massive amounts of data that can be analysed to extract new knowledge about the underlying biological processes.This guide covers aspects of designing microarray experiments and analysing the data generated, and includes information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised, and wherever possible the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression.
Customer Reviews:
A good introduction to the topic .......2007-05-20
Microarrays are a tool for monitoring gene expression levels for thousands of genes in parallel. This technology is very useful since patterns in the gene expression can be used for molecular characterization of phenomena that range from disease states and response to stimuli to the differences between cells of different types. The amount of information obtained from one microarray experiment can be large. These large amounts of information present new challenges in the areas of data storage, management, and analysis by biologists who are not accustomed to dealing with this much data. Also, the software used for data analysis is usually written by mathematicians and statisticians that have a minimum of training in biology.
This book addresses some of the issues faced by researchers who are beginning their first microarray experiments. It covers various aspects of designing and analyzing the results of microarray experiments. Microarrays are not limited to the study of gene expression, but this remains the most common use of the technology and therefore is the only use of arrays discussed here. This book attempts to explain the underlying concepts and principles routinely used in analysis of gene expression data. The book should be accessible by statisticians, computer scientists, and students of bioinformatics who want a grounding in the types of analysis currently used to study microarray data.
The book begins with an introductory chapter which is followed by three major chapters. As with any technology that has the capacity to detect small changes in a highly dynamic system, the underlying experimental design and the manner in which an experiment is conducted is critical for obtaining high quality data. Chapter two addresses these issues. The raw data from microarray experiments are images that must be transformed and organized into gene expression matrices. These transformations are the subject of chapter 3. Finally, in chapter 4, the common methods used for analyzing gene expression data matrices with the goal of obtaining new insights into biology are discussed. The book does a pretty good job of providing the reader with a general understanding of the nature of microarray data and how it can be analyzed. It was never meant to be a reference book or a comprehensive review, just a gentle introduction.
Well written, short explanations but nevertheless understandable.......2005-07-06
Certainly, this book can not give a complete description of microarrays, neither from an experimental nor a theoretical side. Nevertheless, the issues presented and discussed provide the reader with a solid basis for more advanced studies.
In my opinion, this book is well written, the explanations given are descriptive and understandable and its overall organization is plausible. I recommend this book as an introduction for the analysis of microarray data, because it provides a good overview of existing methods in this field. A warning: This does not mean, that all these methods are thorougly expained! It just provides an overview!! If you want to learn, e.g., clustering methods, you should consult another book (probably no other book about microarrays but a decent book dealing only with data analysis in general or clustering methods...)
Book Description
The Biology of Belief is a groundbreaking work in the field of New Biology. Author Dr. Bruce Lipton is a former medical school professor and research scientist. His experiments, and those of other leading-edge scientists, have examined in great detail the processes by which cells receive information. The implications of this research radically change our understanding of life. It shows that genes and DNA do not control our biology; that instead DNA is controlled by signals from outside the cell, including the energetic messages emanating from our positive and negative thoughts. Dr. Lipton's profoundly hopeful synthesis of the latest and best research in cell biology and quantum physics is being hailed as a major breakthrough showing that our bodies can be changed as we retrain our thinking.
Customer Reviews:
Biology meets Spirituality.......2007-10-01
DOCTOR PETER TEIMAN DAVIS here,
A book of the highest existential order.
DOCTOR PETER TEIMAN DAVIS
Sweden
Not as groundbreaking as it suggests.......2007-09-19
I certainly applaud the author, especially one from such a science-oriented background, for writing this book. He attempts to "prove" the power of the mind with scientific studies, etc. On some levels he succeeds; there are certainly some surprising and interesting studies he cites.
However, the book is entirely too filled with tedious, dry scientific discussion that, in my opinion, really didn't need to be there. He could've greatly shorted that part of the book. Also, I can't help but raise and eyebrow at parts of the book where the author says things like "I discovered the secret of life." His "secret" is something that, if you've been involved at all in "alternative medicine" for any amount of time, you'd already know. Also, I think that comment was entirely inaccurate. I didn't come out of this feeling there was any ground-breaking, belief-shattering discovery. Compelling, yes, powerful, yes, but come on, don't go overboard.
In the end, he provides very little that you can actually do to change your biology, other than "think positive thoughts" and similar things. Again, something energetic healers have known for decades, if not centuries. Almost as an afterthought, he has a section at the end, about two pages, where he mentions an exciting new science based on energetic psychology, that can greatly change peoples long-standing beliefs, and reprogram their subconcious, leading to true change. THAT is what I was lead to believe THIS book was about. So, overall, I would skip this book and get another book that actually expands on this idea.
Great book.......2007-09-06
I learned a lot from this book. Its a wonderful book with a wealth of information. I would definitly use that knowledge to use.
The Biology of Belief.......2007-09-04
Life changing. It needs to be read and re-read since it challenges current paradigms with well-backed, scientific data.
Contemporary Scientific Wisdom.......2007-09-03
"The Biology of Belief: Unleashing the Power of Consciouness, Matter & Miracles" by Bruce Lipton is an easy to read book filled with insights into the personal, biological transformation that results when practicing intentional living, higher vibration consciousness, and co-creation with the universe.
I highly recommend The Biology of Belief which is replete with the most recent contemporary scientific wisdom.
Another favorite recent find of mine that is a 'must read'...is a novel about a consciousness based healing journey, spirituality, metaphysics, abundance and life transformation...
Nexus: A Neo Novel
Book Description
Genetics: From Genes to Genomes is a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Second Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.
Customer Reviews:
Genetics: From Genes to Genomes.......2006-02-23
Great figures to go with the text. Not a quick read, but it is a great genetics resource.
Genetics: From Genes to Genomes.......2005-02-07
I found this book extremely verbose and unorganized. It would serve as a great reference book for a lab researcher or grad student. But it's way too technical and dense for an introductory genetics class. The authors do a poor job presenting the material in a comprehensible way to an undergraduate genetics student. Not recommended.
Great general Genetics textbook.......2004-12-12
I think this is a great text book for General Genetics class! In fact, this is the text we have been using at UC Berkeley.
The authors are not only clear & concise in delivering their topics, but also able to formulate challenging questions to test students' undestanding.
Genetics concepts well understood.......2003-09-14
Excellent book that goes in depth to the science of genetics.
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- Principles of Biostatistics (with CD-ROM)
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