Average customer rating:
- Excellent and useful text.
- Destined to become an Oprah Book Club selection
- Keeps getting better with each Edition
- Rara avis
- A classic. Still authoritative.
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Ion Channels of Excitable Membranes (3rd Edition)
Bertil Hille
Manufacturer: Sinauer Associates
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ASIN: 0878933212 |
Book Description
Ion channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded Third Edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
Customer Reviews:
Excellent and useful text........2006-11-17
This text is an encyclopedia of information from kinetics to structure to interactions. It's got a reserved space on my academic bookshelf.
Destined to become an Oprah Book Club selection.......2005-12-08
Some books have opening sentences that grab you in an instant. "Call me Ishmael." "It was the best of times, it was the worst of times." And now, Hille joins the list of authors to reach out and grab us, with the awe-inspiring "Ion channels are macromolecular pores in cell membranes."
Even after my fifth reading, that line still gives me the shivers.
But it takes more than a brilliant opening to make a great book, and Hille delivers. From a distinctly jaunty derivation of the Nernst equation to the page-turning thrills of non-stationary fluctuation analysis, the book is hard to put down. It does bog down a little in Chapter 10, "Elementary Properties of Ions in Solution"--after all, is there anyone who isn't already aware of the fundamentals of electrodiffusion? But this is really a minor trifle in an otherwise masterful work.
It's just a matter of time before Oprah gives this book a nod; buy it now and avoid the rush!
Keeps getting better with each Edition.......2002-03-27
This book is a must-have for anyone working with excitable cells, be they experimentalists or modelers. It's a great reference book; everything is clearly indexed and almost compulsively cited. I've been using this book since its first edition, and it just keeps getting better each time.
Rara avis.......2002-02-09
This classic deserves all the praise it gets. It is an excellent introduction to the molecular biology of channels, told with an eye to history as well as science.
A classic. Still authoritative........2001-08-13
This is an authoritative textbook on ion channels that is often quoted in numerous textbooks in neurophysiology. Hille himself has contributed a lot in this field. The Hogkin-Huxley model is the de facto standard model in neurophysiology but certain things about neurons cannot be explained only with voltage-controlled sodium and potassium channels. With the patch-clamp technique, we have found a way to explore other interesting channles. To remind you, there are a world of ion channels! Hille's textbook show there are indeed a variety of channels most of which are poorly understood. As a reviewer below has commented, it also gives a unique insight into the history of neural membrane research. Concepts are explained with clearity. Details measurement techniques.
Book Description
Benson's SHORT is designed for a 1 or 2-semester A&P course where no single dissection specimen is used. In addition to the dozens of effective exercises, this lab manual is unique in that students are asked to label many of the figures to reinforce concepts. It is self-contained, detailed, and very logical in its approach. Because of its detailed content (textual material, line art, photos, and histology micrographs), it is generally not necessary to take the course textbook to the lab.
Book Description
Anatomy and physiology, a key part of the core curriculum in surgical technology, is the central basic science course around which the knowledge of surgical technology revolves. However, most conventional A&P books do not cover the surgical aspects of anatomy and physiology that the Core Curriculum for Surgical Technology requires. Surgical Anatomy and Physiology for the Surgical Technologist provides the basic concepts of A&P and applies them to practical surgery. Throughout the book, examples show how the anatomy and physiology of a particular body system or organ relates to a surgical procedure. This resource includes case studies, review questions, key terms, objectives for each chapter, and information boxes that tie specific anatomical elements to surgical practice. This book meets the requirements of the current edition of the Core Curriculum for Surgical Technology.
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Planar Lipid Layers (BLMs) and their Applications (Membrane Science and Technology)
H.T. Tien † , and
A. Ottova-Leitmannova
Manufacturer: Elsevier Science
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ASIN: 0444509402 |
Book Description
The lipid bilayer is the most basic structural element of cell membranes. A wide range of topics are covered in this volume, from the origin of the lipid bilayer concept, to current applications and experimental techniques. Each chapter in this volume is self-contained and describes a group's research, providing detailed methodology and key references useful for researchers. Lipid bilayer research is of great interest to many because of it's interdisciplinary nature.
· Provides an overview of decades of research on the lipid bilayer
· 38 contributed chapters, by leading scientists, cover a wide range of topics in one authoritative volume
· Book coincides with 40th anniversary of BLM
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Chemical and Physical Behavior of Human Hair
Clarence R. Robbins
Manufacturer: Springer
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Nanobiotechnology of Biomimetic Membranes (Fundamental Biomedical Technologies)
ASIN: 038795094X |
Book Description
Human hair is the subject of a remarkably wide range of scientific investigations. Its chemical and physical properties are of importance to the cosmetics industry, forensic scientists, and to biomedical researchers. The fourth edition of this book confirms its position as the definitive monograph on the subject. Previous editions of this book were recognized as "concise and thorough" Features of the Fourth Edition: * New information on chemical damage from permanent waving, bleaching and sunlight and how to minimize or prevent this damage. * A new view of the cause of dandruff is presented with new supporting data. This view suggests new approaches for both treatment and for marketing of scalp care products. * The latest information on the science of hair growth and hair growth stimulating agents is provided, including Propecia. * A new section has been added on skin and eye irritation and skin sensitization from ingredients used in hair care, and a model has been provided to predict relative skin irritation of shampoos. * New micrographs on "normal hair fiber shape variations" and how fiber shape can influence chemical and physical interactions of hair fibers will be covered. * Additional material is now included on hair straightening. (Journal of the American Chemical Society), "an invaluable resource" (Canadian Forensic Science Society Journal), and "highly recommended" (Textile Research Journal). Chemical and Physical Behavior of Human Hair is a teaching guide and reference volume for cosmetic chemists and other scientists in the hair products industry, academic researchers studying hair and hair growth, textile scientists, and forensic specialists.
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- The answer is in here ...and here is the question:
- Fantastic Compendium of Channelopathies
- The very first book of a kind
- Outstanding! Essential reading in modern molecular medicine
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Ion Channels and Disease: Channelopathies
Frances M. Ashcroft
Manufacturer: Academic Press
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ASIN: 0120653109 |
Book Description
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies.
Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered.
This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology.
Key Features
* Introduces the relevant aspects of molecular biology and biophysics
* Describes the principal methods used to study channelopathies
* Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function
* Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Customer Reviews:
The answer is in here ...and here is the question:.......2001-05-20
The author has a splendid writing gift, and she has produced a broad and wonderfully clear survey of the state of the art in this vigorous field. For a detailed summary of what you will find in the book, check the editorial review (above) from the New England Journal of Medicine.
It seems to me the book might well be read in the context of two other important books in this field: One is Bertil Hille's classic, "Ionic Channels of Excitable Membranes." As a science gathers momentum (and this one is certainly surging) we tend to lose track of what is known and what is simply assumed. Hille's book will fill in some blanks at the fundamental level - and show you exactly where the underlying assumptions are in this science. If you are at all skeptical, and of course you should be, you will like Hille's calm precision and care.
The other background book is Spikes, by Rieke et al. The implication of Spikes is that Adrian was wrong and that, therefore, all of us have been wrong about what nerves actually do - and wrong since 1926. The authors put this rather more diplomatically than I have, but there it is: Adrian wrong.
Spikes summarize evidence accumulated since about 1993 that a single nerve impulse, all by itself, can somehow convey information to the brain. This shocking news will have to be either explained or explained away in terms of the biochemical machinery of the neuron. The current explanation (which is based on precise arrival timing) would seem to rely upon the physiological equivalent of a quartz crystal, um, a device we don't often come across in biochemistry.
It would be my guess that a better understanding of ion channels will point to a more biologically realistic solution. And a new and better picture of how the neuron works.
Ion Channels and Disease is the most current and broadest survey of the subject. The key to the problem is probably in here somewhere, or is referenced here, and is waiting to be discovered. I would pay particular attention to any type of evidence for linkage, structure or signaling between "individual" channels. Linkage between discrete trans-membrane ion channels could create a longitudinal channel running the length of the nerve, probably many of them. A multi-channel axon - a cable rather than a wire -- would be one possible solution to the new mystery of how a single impulse can be freighted with graded information.
Fantastic Compendium of Channelopathies.......2000-01-04
This is a fantastic book for anybody interested in ion channels or molecular medicine. If you happen to be a graduate student preparing for an exam in the field - this is your salvation! Personally, I read it with enormous delight. What a great compendium of this fascinating, quickly growing field! The style is very elegant, everything is lucid, the concepts come through crystal-clear. This was certainly an enormous amount of work and the book will be helpful to many in the field - for brushing up on channels that you don't work on, for checking things quickly, for teaching, and just for fun!
Blanche Schwappach, Howard Hughes Medical Institute, University of California, San Francisco
The very first book of a kind.......1999-11-11
This is really a landmark achievment to write such a good book in such a way, understandable .
Outstanding! Essential reading in modern molecular medicine.......1999-10-18
This is a lucid discussion of the role of ion channels in disease. It begins with a wonderful introduction to molecular biology and physiology of ion channels suitable for neophyte as well as the seasoned investigator. Then individual ion and ligand gated channels are discussed in individual chapters. After the basic properties of each channel are introduced, diseases of the channels are discussed.
Book Description
Designed for the one-semester course, Essentials of Anatomy and Physiology is written to allow instructors the ability to accomplish one main goal: to teach the basics of A&P while fostering the skills of problem solving. The text focuses on two major themes: 1)the relationship between structure and function, and 2)homeostasis.
Customer Reviews:
A book you can learn a lot from!.......2000-08-07
This book is a great learning tool! It "teaches" you about your own body, how it works and why you should care about what you eat, exercise, etc. The book is very well structured, with an objectives list at the beginning of each chapter and reasoning skills questions at the end, that helps you develop study and observation skills. This is a great book that changed the way I see my body, I learned a lot with this book!!
Book Description
Benson's COMPLETE is designed for a 2-semester A&P course. In addition to the dozens of effective exercises, this lab manual is unique in that students are asked to label many of the figures to reinforce concepts. The cat is the primary dissection specimen in this manual. It is self-contained, detailed, and very logical in its approach. Because of its detailed content (textual material, line art, photos, and histology micrographs), it is generally not necessary to take the course textbook to the lab. The atlas of quality histology micrographs has always been a strong feature and makes it unnecessary to purchase an additional histology atlas.
Customer Reviews:
Thorough book and very descriptive.......2002-01-24
I had to use this book for a college class I was taking (Anatomy
and Physiology) and I was surprised by the great detail and thoroughness of this book. I was highly impressed!
This lab book contains many different exercises to help you comprehend some of the difficult strutures and functions of the body.
A must for all those taking A&P in college!
Book Description
This laboratory manual is ideal for introductory, two-semester anatomy and physiology students. This new edition works well with any textbook and includes complete explanations of essential information. Clear, step-by-step procedures for each exercise are accompanied by detailed illustrations and labeling exercises. The main dissection specimen is the cat.
Customer Reviews:
Excellent Lab Book for new Nursing Student.......2006-06-15
Step-by-step guide to all things anatomy. Fantastic illustrations!
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Moving Questions: A History of Membrane Transport and Bioenergetics
Joseph D. Robinson
Manufacturer: An American Physiological Society Book
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ASIN: 0195105648 |
Book Description
This book describes half a century of progress in two mainstream areas of biological research: membrane transport, initially a focus of physiologists, and oxidative phosphorylation, initially a focus of biochemists. Robinson shows how the development of new explanatory models had unexpectedly merged these inquiries into a new field, bioenergetics. In the late 1930s, explanations for the asymmetric distribution of ions between cells and their environments invoked absolute impermeabilities of the cell's surrounding membranes. But new experiments contradicted that idea and demonstrated that forming the transmembrane distributions required metabolic energy, implying the participation of active transport "pumps." Subsequent studies identified, isolated, and characterized these pumps as enzymes coupling ionic transport to the consumption of adenosine triphosphate (ATP), an "energy-rich" molecule serving as a cellular energy store. In the late 1930s oxidative phosphylation, the process of coupling ATP synthesis to oxidative metabolism, was identified. The explanatory model emerging in the next decades, however, did not follow the enzymatic precedents of known metabolic phosphorylations but rather embodied the principle that metabolic oxidations drive active transport pumps to create transmembrane distribution of ions, with these ionic asymmetries then driving ATP synthesis. It was discovered that ATP consumption can form ionic asymmetries; ionic asymmetries can drive ATP formation; and ionic asymmetries-like ATP-can also power other cellular functions.
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