Book Description
A new edition of a bestseller, this book covers the changes that occur with normal aging and disease processes from a physiological basis. Filled with illustrations and tables, it covers topics such as gGenetics of aging, developments in Alzheimer's, new treatments for Osteoporosis, new medications for Diabetes, new treatments for Gastritis, and new Nsaids to treat Degenerative Joint Diseases.
Book Description
Ageless Quest is a personal, sometimes controversial, account of the pursuit of a genetic "cure" for aging by an expert in the field.
The author is the Novartis Professor of Biology at the Massachusetts Institute of Technology.
Aging has always been regarded as a highly complex process with many degenerative changes leading to the cessation of life. But recent research has identified a relatively simple mechanism that governs the pace of aging.
Lenny Guarente's Ageless Quest is a scientific detective story for the baby boom generation. It offers an insider's view of an area of potentially astonishing high reward-and equally high risk.
Customer Reviews:
review of seller.......2007-01-10
Thank you for your very prompt shipment of this book as we specified expediated shipping and this worked out!
--.......2004-01-13
I picked up this book because of the cover. If you care about the scientific story, read it in the review literature. If you want a good read, look elsewhere.
Great behind the scenes view of scientific research.......2002-12-06
As a non-scientist with an interest on what the future may hold for us, I found Ageless Quest to be exceptionally informative, easy to understand, and thought provoking. I had always wondered what went on in those biology research labs, and was grateful to have the "behind the scenes" peek that this book provided. Extremely interesting and enjoyable reading; recommended for all.
Book Description
A few gray hairs and a couple of wrinkles are often the first visible signs of aging on our bodies. For most of us, however, aging remains largely a mystery. We can only wonder why we have to age and what casualty of age hovers nearby. Written in everyday language, The Clock of Ages takes us on a tour of the aging human body--all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of genes that may allow humans to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Billy the Kid, Napoleon, and Casanova. These stories underscore the common bond of senescence that unites us all. The Clock of Ages tells us why.
Customer Reviews:
A very interesting book.......2005-12-30
I really enjoyed reading this didactic book, but I was a little dissapointed at the end.... I thought he was going to talk more about diet and life style, but he didn't. Maybe in a future edition, who knows. Anyway, it's a very good book, you should read it.
A journey into the mechanics of aging.......2000-03-25
Reading this book reminded me of a ride I once took at Disneyland where everything gets bigger and bigger so that you feel as if you are being reduced to microscopic size. You then travel into the human body, then a cell and then see the molecules that make them up. Medina starts with the human face of ageing - the final moments in the life of his aged mother - and then takes us on a journey from the outward signs of ageing to the molecular machinery which makes what he calls the "clock of ages" tick.
Despite our anxieties of "getting old" ageing starts long before we see wrinkles or grey hair. In fact, ageing is a complex developmental process which starts at conception. Despite taking such a biological view Medina never loses sight of the individual. The effects of ageing on the lives of many famous people are interspersed through the book with amazing facts about the body: Florence Nightingale was a hypochondriac who spent most of her adult life in bed and each of us contains about 60,000 miles of blood vessels!
Some in the field claim that our exploding knowledge of the mechanics of cellular renewal and DNA will see us living twice or three times our current life spans in approximately 30 years.
Good Summary But Missing One Discussion.......1999-04-08
Medina's work is an excellent, readable summary of what's currently known about aging. As it turns out, there are more questions than answers.
However, in amongst all the discussion of immortality I wish he had devoted a chapter to the wisdom of such a quest. He mentions in passing the ants and bees who each perform a distinct function and, separated from their hive or nest, expire rather quickly. Medina repeats the oft-quoted maxim that they are more like a single organism with independently-functioning cells than like distinct individuals.
I wish he had extended this analogy to mankind, and showed how immortality would be to the detriment of long-term species survival in a changing environment. "Descent with modifications" relies on continual refreshing of the genetic material. Lewis Thomas and Stephen Jay Gould (and even Richard Dawkins) have put forward the idea that the individual is not the prime target of evolution, and I think this paradigm shift helps explain the causes of, and need for, aging.
"The Clock of Ages" Makes for Good Time.......1997-02-02
"The Clock of Ages" by John J. Medina is subtitled 'Why We Age, How We Age, Winding Back the Clock.' Dr. Medina more adequately addressed the 'Why' and the 'How' of aging than the 'Winding Back the Clock.' As might be expected from a molecular biologist, Medina is at his most technical and most detailed when he is describing the major theories of aging--error accumulation and programmed death. Generally, he succeeds in clarifying technical concepts for the non-technical reader. The book is liberally seasoned with historical vignettes, analogies and diagrams. "Clock" clarifies various definitions of aging, different philosophies of aging and various theories of the biochemistry of aging. At the same time we are introduced to such diverse people as Casanova, Billy the Kid, Isadora Duncan, Alfred Nobel and Florence Nightingale. The vignettes of these people often liven up the book, but at times the analogies made from person to concept are a bit of a stretch.
Medina serves as a tour guide of the aging body with stops at the skin and hair; the bones, the muscles and joints; the brain; the heart; the lungs; the digestive system; the senses; and the sexual anatomy and physiology. "Clock" is mostly a story of decline and fall of the human body with predictions about future high-tech genetic and hormonal antidotes.
The third part of the sub-title 'Winding Back the Clock' only consumes 17 of 316 pages which is not in balance with the other two parts. Medina acknowledges but underplays the role of diet and exercise in winding back the clock. And although Dr. Medina recognizes the wide variability in the way people age as well as the variability of aging within individual body systems, he does not fully recognize the affects of culture and attitude on the aging process, but coming from a biologist this is to be expected. Overall, "Clock" is engaging and thought-provoking. I would, however, recommend several other books to give other views on aging other than the biological--try Betty Friedan's "Fountain of Age," Deepak Chopra's "Ageless Body, Timeless Mind" or Delany, Delany & Hearth's "Having Our Say: The Delany Sisters' First 100 Years."
Book Description
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
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Neuroglia in the Aging Brain (Contemporary Neuroscience)
Manufacturer: Humana Press
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ASIN: 0896035948 |
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A distinguished panel of internationally recognized neuroscientists comprehensively review the involvement of and changes in glial cells both during the normal aging process and in the major disorders of old age. Topics range from the cellular and molecular changes that occur with aging-especially aging-associated activation of astrocytes and microglia and its relation to neuronal injury and repair-to neuron-glia intercommunication. The contributors show how glial signals may be modulated by hormones, growth factors, neurotransmitters, intracellular metabolism, and intercellular exchanges, as well as by aging of the blood-brain barrier.
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Modulating Aging and Longevity (Biology of Aging and its Modulation)
Manufacturer: Springer
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ASIN: 1402013698 |
Book Description
After decades of systematic collection of data describing age-related changes in organisms, organs, tissues, cells and macromolecules, biogerontologists are now in a position to construct general principles of ageing and explore various possibilities of intervention using rational approaches. While not giving serious consideration to the claims made by charlatans, it cannot be ignored that several researchers are making genuine attempts to test and develop various means of intervention for the prevention and treatment of age-related diseases, for regaining the functional abilities and for prolonging the lifespan of experimental organisms. This book provides the most up-to-date information and a critical evaluation of a variety of approaches being tried for modulating aging and longevity, including dietary supplementation with antioxidants, vitamins and hormones, genetic engineering, life-style alterations, and hormesis through mild stress. The goal of research on ageing is not to increase human longevity regardless of the consequences, but to increase active longevity free from disability and functional dependence.
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Aging Methods and Protocols (Methods in Molecular Medicine)
Manufacturer: Humana Press
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ASIN: 0896035824 |
Book Description
Yvonne and Christopher Barnett and a team of recognized international experts detail key biochemical, analytical, and molecular techniques for the investigation of aging at the cellular, tissue, organ, and whole system levels. These cutting-edge methods address a wide range of research needs, from uncovering the factors associated with cell senescence and death, to exploring alterations in the body's ability both to metabolize xenobiotics and to defend itself against biomolecular damage. State-of-the-art protocols also measure the morphological, functional, and molecular changes that accumulate within mitochrondria over time, and permit the genetic and functional characteristics of the immune system to be determined. Wide ranging and highly practical, Aging Methods and Protocols provides today's molecular gerontologists, pharmacologists, and clinical investigators with a gold-standard collection of readily reproducible techniques for identifying those key cellular and molecular processes that might one day make it possible to regulate the aging process.
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Cartilage Molecular Aspects (Telford Press)
Brian K. Hall , and
Stuart A. Newman
Manufacturer: CRC
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ASIN: 0849388171 |
Book Description
Cartilage plays diverse roles as a definitive supporting tissue in some organs, the basis of low friction surfaces in joints, and a transient morphogenetic template during embryogenesis and repair of the skeleton. The versatility of cartilage is derived from the remarkable material properties of its extracellular matrix, the wide spectrum of regulatory systems that influence the synthesis and degradation of the unique molecular constituents of this matrix, and the development and growth of the cells that produce it. This book touches on each of these areas and provides the first comprehensive reviews of the molecular biology of the genes specifying the collagenous and noncollagenous proteins of the cartilage matrix, as well as the biophysical-chemical properties of the matrix that suits it to the various functions it performs. Up-to-date critical reviews of the mineralization and degradation of cartilage matrix, the roles of polypeptide growth and inducing factors, of ions, in the regulation of cartilage growth and development, and the unique requirements of the energy metabolism of cartilage as a nonvascular tissue, make this volume a useful source for concepts and results for the multiple disciplines that play a part in modern cartilage research.
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- Human body is made of cells, its aging is important.
- Human body is made of cells, its aging is important.
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Cellular Aging and Cell Death
Manufacturer: Wiley-Liss
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ASIN: 0471121231 |
Book Description
Cellular AGING AND CELL DEATH
Edited by Nikki J. Holbrook, George R. Martin, and Richard A. Lockshin
Cellular Aging and Cell Death provides a thorough understanding of the mechanisms responsible for cellular aging, covering the recent research on programmed cell death and senescence, and describing their role in the control of cell proliferation and the aging process. This one-of-a-kind book is the first to combine the two hottest research areas of cell biology into one comprehensive text.
Leading experts contribute to give readers an authoritative overview of the distinct fields of cellular aging and programmed cell death, as well as to demonstrate how both fields are critical to understanding the aging process. They address the large and growing interest in apoptosis, especially with regard to the molecular signals that induce and regulate programmed cell death, and the role of apoptosis in a variety of age-associated diseases and disabilities. Throughout the book, a strong emphasis is placed on the interrelationship of the molecular, cellular, and physiological aspects of senescence.
Individual chapters discuss such topics as the role and regulation of apoptosis in development, the potential impact of cell death on such postmitotic tissues as nerve and muscle, and suggest that programmed cell death plays an important role in both pathological and nonpathological aspects of aging, including neurodegenerative diseases.
One important chapter focuses on the most recent research involving the study of telomeres, whose reduction in length with age and cell division may underlie cellular senescence. The subject of neuronal cell death is also put into the perspective of aging.
Cellular Aging and Cell Death bridges the rapidly growing fields of cellular aging and programmed cell death. This thorough, yet concise book will be of particular interest to graduate students and researchers within the fields of cell and developmental biology, neurobiology, immunology, and physiology. Physicians and medical students involved in the fields of gerontology and pathology will also find this an informative reference.
Customer Reviews:
Human body is made of cells, its aging is important........1999-04-12
Cell of the body must have the proper environment. Developmental changes (age changes) can be explained better at the cellular level. Errant condition and failure to correct lead to cell injury. The greater the number of cells injured the more likely system malfunction would occur.
Human body is made of cells, its aging is important........1999-04-12
Cell of the body must have the proper environment. Developmental changes (age changes) can be explained better at the cellular level. Errant condition and failure to correct lead to cell injury. The greater the number of cells injured the more likely system malfunction would occur.
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- Reincarnation and Biology: A Contribution to the Etiology of Birthmarks and Birth Defects Volume 1: Birthmarks
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