Book Description
The Biology of Cancer is a comprehensive, authoritative, up-to-date textbook written by a major researcher in the field. It clearly presents the principles of cancer biology in an organized and accessible fashion. The information unfolds through the presentation of key experiments which give readers a sense of discovery, and provides insights into the conceptual foundation underlying cancer biology.
Customer Reviews:
Great Book.......2007-10-05
It's a great book for a concise and comprehensive review of cancer and its pathways.
fantastic book.......2007-06-14
This book is a fantastic read for anyone interested in the cancer biology. It is well-written, comprehensive, current, and the illustrations are superb. The enclosed CD-ROM of the book's figures has proved invaluable for creating Powerpoint presentations on various topics in cancer.
Biology of Cancer by Robert A. Weinberg.......2007-05-14
Excellent, clear, comprehensive overview with useful CD supplement
The Biology of Cancer CL, by Robert A. Weinberg.......2007-05-07
it is a must have book for someone in cancer research. It covers both molecular and biological aspects of cancer very well.
Comprehensive.......2007-03-10
As a colorectal cancer survivor, I've undertaken a self-study of my cancer in particular, and the disease in general. Saltz's Colorectal Cancer is the comprehensive text for me, but it is better read with a foundation in the nuts and bolts of the disease. Sompayrac's How Cancer Works is a wonderful text for explaining what the nuts and bolts are, but this book, Biology of Cancer, not only explains these in better detail, it also explains how researchers figured all this out. The illustrations, graphs and photos are worth the price of the book itself--you can see the discoveries unfold in front of your own eyes. You don't have to be a scientist to start reading it, but you will probably have to become something of a scientist and retain what you are absorbing as you progress through the book. This is a textbook that is something of an all-star collection of information from a variety of scientific research textbooks.
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Tumor Models in Cancer Research (Cancer Drug Discovery and Development)
Manufacturer: Humana Press
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Mouse Models of Human Cancer
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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics (Cancer Drug Discovery and Development)
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Anticancer Drug Development Guide (Cancer Drug Discovery and Development)
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Biology of Cancer
ASIN: 0896038874 |
Book Description
Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.
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Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, 2nd Edition
Manufacturer: Wiley-Liss
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Robbins & Cotran Pathologic Basis of Disease, Seventh Edition
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Molecular Biology of the Cell, Fourth Edition
ASIN: 0471250716 |
Book Description
The groups of specialized cells that make up the various human tissues depend on an intricate communication network to regulate gene expression that in turn mediates growth, cell-type specific function, division, and programmed cell death. This network consists of extracellular signals interacting with the receptors of individual cells and determining the fate of each. Since this regulatory system plays a critical role in complex tissue, aberrations or malfunctions often accompany the onset and progression of cancer.
Cell Cycle and Growth Control: Biomolecular Regulation and Cancer, Second Edition provides a solid basis for understanding cell cycle and growth control as it relates to biological regulation, with a special emphasis on examining these processes in the context of cancer. Newly updated with the latest significant advances, this Second Edition features:
* Cutting-edge applications in clinical diagnostics and therapeutics
* Focus on mechanisms mediating the control of proliferation
* Numerous clear illustrations
* Extensive bibliography
* Well-recognized, expert chapter authors
* Video clips on accompanying Web site showing cell cycle control
Cell Cycle and Growth Control, Second Edition offers both an introduction to important concepts and detailed discussion of regulatory mechanisms at the cellular, biochemical, genetic, and molecular levels. The only book to comprehensively cover both the foundations and cutting-edge advances in understanding cell cycle and growth control, this text also contains an expert perspective on innovative strategies for cancer treatment, making it a vital companion for researcher and clinician alike.
Book Description
This book is a bench manual that provides in one volume all the important and unique technologies necessary to studies of mammary gland biology and breast cancer. The chapters are written by experts in each area with an emphasis on nitty-gritty details that are key points for the successful use of a method. Sections include
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in vivo studies,
in vitro model systems, and molecular analysis and gene transfer techniques.
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Principles of Cancer Biology
Lewis J. Kleinsmith
Manufacturer: Benjamin Cummings
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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics
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ASIN: 0805340033 |
Book Description
Principles of Cancer Biology,is an engaging book focused on providing readers with a âbig pictureâ view of cancer. Author Lewis Kleinsmith has written an instructional text focusing on key concepts for a general audience. Each chapter contains a list of suggested readings that expand the detail as needed. The text also emphasizes the scientific evidence that underlies cancer biology, and teaches readers to think critically about this evidence- as there are constantly new âbreakthroughsâ and reports in this field. For readers who need the review, there are brief reviews of several topics related to DNA replication and repair, cell division, cell signaling, and inheritance patterns in chapters where these subjects are relevant. By including these reviews, the text is both accessible and engaging to a broad audience of readers who are studying cancer biology for the first time, as well as an interested general audience.
What Is Cancer, Profile of a Cancer Cell, How Cancers Spread, Identifying the Causes of Cancer, Chemicals and Cancer, Radiation and Cancer, Infectious Agents and Cancer, Heredity and Cancer, Oncogenes, Tumor Suppressor Genes and Cancer Overview, Cancer Screening, Diagnosis, and Treatment, Preventing Cancer, Main Types of Cancer, Human Carcinogens.
For all readers interested in the big picture view of cancer.
Customer Reviews:
Quick shipment - Perfect book.......2006-03-19
Great! I am very satisfied. Quick delivery and book in perfect condition.
Excellent Textbook.......2006-02-25
This textbook provides very up-to-date theories and information on the causes and treatments of cancer. It begins with a discussion of cancer in general and moves on to describe its various forms. Throughout the text, it strikes a balance between detail and relevance. In describing the mechanisms of cancer, the book provides an excellent introduction to various cell processes. The book also has chapters on the current treatments, statistical data (and the various methods and jobs associated with it), the history of various types of cancers, and the types and actions of various carcinogens. This book is an excellent text for anyone interested in the various aspects of cancer.
Book Description
This comprehensive book and CD-ROM learning package is designed for the oncology nurse preparing for certification and/or recertification.
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Prostate Cancer: Biology, Genetics & the New Therapeutics (Contemporary Cancer Research)
Manufacturer: Humana Press
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ASIN: 0896038688 |
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Leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer and its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth and progression has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.
Book Description
Essential Mathematical Biology is a self-contained introduction to the fast-growing field of mathematical biology. Written for students with a mathematical background, it sets the subject in its historical context and then guides the reader towards questions of current research interest, providing a comprehensive overview of the field and a solid foundation for interdisciplinary research in the biological sciences.
A broad range of topics is covered including: Population dynamics, Infectious diseases, Population genetics and evolution, Dispersal, Molecular and cellular biology, Pattern formation, and Cancer modelling.
This book will appeal to 3rd and 4th year undergraduate students studying mathematical biology. A background in calculus and differential equations is assumed, although the main results required are collected in the appendices. A dedicated website at
www.springer.co.uk/britton/ accompanies the book and provides further exercises, more detailed solutions to exercises in the book, and links to other useful sites.
Amazon.com
"Cancer wreaks havoc in almost every part of the human body"--Robert Weinberg's opening remark is a chilling reminder of the pervasiveness of an all-too-familiar disease. Cancer touches most families, and if you have ever wondered why, despite so much time, effort, and money, it has proved such a seemingly intractable problem, then read One Renegade Cell, Robert Weinberg's masterful explanation. As director of the Oncology Research Laboratory at the Whitehead Institute and professor of Biology at MIT, Weinberg has been at the forefront of cancer research for well over a decade.
Unlike most diseases, cancerous tumors are not foreign invaders but "take on the appearance of alien life forms, invaders that enter the body through stealth and begin their programs of destruction from within." But as Weinberg shows, these are deceptive appearances. And since he is foremost a scientist, he finds the truth "subtle and endlessly interesting" and manages to convey fascination for something that most of us dread--cancer. Much of the present increase in cancer is due to increased longevity because "given enough time, cancer will strike every human body."
By telling the story of the historical discovery of cancer, Weinberg is able to introduce gradually the intricacies and complications of the genes and proteins involved (oncogenes, tumor suppressor genes, etc.) for the general reader. He characterizes cancer cells as renegade because, unlike normal body cells, they "disregard the needs of the community of cells," they are "selfish and unsociable," and are only interested in "their own proliferative advantage." By comparison, normal cells hold down cell numbers by "inducing them to commit suicide" (apoptosis).
The understanding of cancer has been developed enormously over the last few decades by Weinberg and the worldwide community of researchers. As Weinberg eloquently shows, cancer research and its related disciplines "have moved from substantial ignorance to deep insight." --Douglas Palmer, Amazon.co.uk
Book Description
For everyone whose life has been touched by cancer, One Renegade Cell tells the story of the search for the ultimate causes of this dreaded disease.
"One Renegade Cellâ¦offers a breathtaking picture, both wonderful and frightening, of the fantastic intricacy of aberrant cellular functioning." -New York Times
"Part primer, part history and part meditation. [One Renegade Cell] succeeds on all counts." -Wall Street Journal
One of the leading cancer researchers in the world, Robert A. Weinberg is perfectly suited to describe the search for cancer's origins from the early days of this century to the present. Presuming little knowledge of biology, he tells how a cancer-causing virus was first discovered in 1909, how the correlation was made between chemical carcinogens and cancer, and how oncogenes (the genes that can turn a cell malignant) work. He explains clearly how malignant cells send messages to one another and also block the messages of normal cells. Finally, Weinberg predicts that cancer prevention may depend on our ability to understand the mysterious chemical clock that regulates our cells' most basic functions. One Renegade Cell offers a concise, accessible route into the complex and often daunting world of cancer and cancer research.
Customer Reviews:
Must read.......2007-05-24
This is an amzaing manuscript. By leading the reader through the key discoveries in modern molecular oncology , Weinberg is able to elucidate the hallmarks of carginogenesis in simple, yet comprehensive ways.
This is a must read for any doctoral student. However, Weinberg simple and entertaining language will be enjoyed by anybody who has an interest in the pathways that lead to cancer.
History of cancer theories for the layperson.......2007-04-17
Here's a book that I would recommend to those people interested in learning a bit about the beginnings of cancer. In One Renegade Cell, Robert Weinberg has written an informative narrative on the history of cancer and molecular biology research, focusing on the theories and evidence behind the early days of this field: the 1970's and 80's.
Weinberg's focus is on what he knows best: the mechanisms that promote and regulate the proliferation of normal and malignant cells. And for that, his explanations are the best out there. These explanations take up the first half of the book, corresponds to the early events in the development of a tumor, and makes up a coherent story. For example, he covers oncogenes, tumor suppressors, apoptosis, and to a lesser extent DNA repair, in relatively easy-to-follow language.
In the second half of the book, Weinberg refers to other aspects of cancer progression, more reflective of the later stages of cancer - angiogenesis, immune evasion and metastasis. He essentially provides the highlight reel for these aspects of cancer, and I felt that the transitions to such topics could have used some work. But that's okay in my opinion, because Weinberg comes right out and says it on the cover - this book is specifically about *the beginning* of cancer, first and foremost.
Weinberg also avoids using overwhelmingly long lists of references that are typical of more scientific writing, as well as skipping over the many highly-technical details that are involved in actually conducting such research, making it more accessible to non-experts. Indeed, he defines every term in a way that probably only requires a minimal background in biology to understand.
Excelent entry to cancer biology.......2004-04-11
There are very few books out that give the reader an overview modern cancer biology. This short book gives a clear picture of a complex and current subject. It uses historical perspective on scientific discovery to enliven the reading. It's well organized and readable without background in biology, but with enough depth to interest biologists in other fields. I also reccomend Robert Weinberg's "Genes and the Biology of Cancer", written with Harold Varmus, which covers the same material in a little more depth.
Valuable information!.......2004-02-12
Extremely informative, written in interesting form like a scientific novel, a systematic mini-survey of the molecular biology of cancer. Takes you through 30 years of discovery, explaining how false expectations were replaced by the discovery in laboratories of right pathways. Among the useful pieces of information you'll pick up: cancer cells are not destroyed by chemo and radiation, only some DNA damage occurs. Unless the p53 gene is little enough damaged, then the tumor is not stopped, and Weinberg explains why. He fully describes the 6 mutations that are required, over time, to produce a metastasizing tumor. My wish: that Weinberg would next write a book about cancer treatments.
I end with an aside for those who are in love with the red herring called "holism", and imagine that "reductionism" is dead and of little or no use in the elucidation of complexity. The entire field of genetic and cancer discoveries, all of microbiology, is nothing but plain ol' reductionism applied to very long molecules, molecules so long and often disordered in shape that new techniques of chemical analysis had to be invented (like PCR). This book and any standard text on molecular biology provides full evidence for the truth of my assertion.
Must have: great intro and overview of current research.......2002-10-17
No prior knowledge of cell biology or genetics is required. I have gained an appreciation for the complexity of cancer research thanks to the book. I highly recommend it. You also learn a fair amount of the history of the development of cancer research. And don't think you need to read through hundreds of introductory pages to accomplish this. The book is under 200 pages.
Once again: What I found great about the book is it explains very clearly the current thories on how cancer starts and spreads without requiring any prior knowledge in the field.
For the scientifically oriented who are interested in the details, it has a big reference and endnote section. 5 stars for sure.
Book Description
Many of the cells in our body undergo tightly regulated replication to enable growth to occur, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, and shows how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. The Molecular Biology of Cancer will prove a valuable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control. Companion Web Site Features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources.
Customer Reviews:
Easy to read!.......2007-04-02
This is a good introduction to this field. The book is easy to read and have good drawings.
An Introduction to the Biology of Cancer - and More.......2007-01-12
I'm one of those people who like to know how things work - especially if those things are inside my body and are likely to shorten my life span. Since my doctors don't tell me anything, I need other sources, and since the Internet is unreliable, I need a guidebook I can trust. Molecular Biology of Cancer turned out to be just the right book for me. It is also an excellent first book for anyone interested in the molecular biology of cancer.
First, as to technical level: This is very much what one expects in an undergraduate science text, with lots of section headings, lots of diagrams, and lots of boxes highlighting important points. If, like me, you're a non-student and non-scientist but interested in the subject, you'll probably find it very readable. You'll need to have some experience of reading diagrams in which symbols (squares, circles, etc.) represent molecules interacting with each other. And you'll have to be comfortable reading books with plenty of technical language. The terms specific to cancer biology should be no problem since they are well-explained and the terms that are in the glossary are printed in red in the text. You won't need to know anything about the chemistry involved in the molecular interactions (nothing about hydrogen bonding or redox, for example).
Some single-celled organisms can simply grow and divide as fast and as long as their food supply allows. Those that live in colonies must have chemical signals to regulate each cell's growth and activity. Mammals, being enormously more complex, need much more sophisticated communication between cells. That means, of course, that there are many things that can go wrong and many mechanisms to fix things that go wrong. And therefore, there are many things to be considered when diagnosing and treating cancer. Pecorino chooses particular examples to explain general principles.
First, a cell normally doesn't divide until a signal from outside sets off a chain of events that leads to division. An error in this chain, caused by an abnormal protein, can cause the cell to divide without the external signal. Pecorino chooses epidermal growth factor (EGF) to show the working of such a chain. When a cell does start to divide out of control, there are mechanisms which try to stop the reproduction, or to kill the cell. Pecorino focuses mostly on one molecule, called P53, which is involved in a number of such mechanisms and is abnormal in a majority of tumors, including mine. Most cells are fastened in place, so it takes a further abnormality for them to break loose. Since most cancers are caused by abnormal or inappropriately expressed genes, DNA repair and regulation are important. Here, Pecorino mentions the BRCA genes, which turn up often in articles about breast cancer. These are major topics, but there is much more than I can mention in an Amazon-size review.
So many genetic flaws don't show up all at once; a cancer is the product of evolution within one body. This is implicit in Molecular Biology of Cancer, but it is more developed in another book, Darwin in the Genome. (See my review for more info; click above on "See all my reviews".)
Given that there are so many molecular systems involved in cancer, one can see why there are many points at which drugs may inhibit or kill cancer cells. Pecorino points out a number of these. She even flags many these with red target icons, symbolizing potential drug targets. Perhaps by the time a student gets to be a researcher, most of these will be passé - a lot of people are working hard on them -- but her aim is to teach them how to spot potential target molecules and interactions and I think she succeeds.
Cancer can be of interest to people who aren't affected by it because, by showing what happens when things go wrong, it gives new insight into how these systems work in general. For those interested in developmental biology, it shows what happens inside a cell in response to a signal whereas most of the books I've read just mention the cellular interactions. Pecorino also gives examples of how a large variety of molecules may be created by mixing and matching a much smaller collection of simpler molecules or domains; this modularity is important in evolution.
So this book will be of interest to a variety of readers for a variety of reasons. Pecorino is particularly interested in students and hopes that some will be inspired by this book to take up cancer research. I second that and I hope that some will find metastatic prostate cancer to be a worthy field.
An excellent introductory book!!!.......2006-05-05
I got this book for the Cancer Biology class.
It's an excellent book to start learning about cancer. It's well updated and includes all the recent advances. It could have included some extra stuff in my opinion, but anyway it's a great book. I like the "future therapeutics" part at the end of each chapter.
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- Biology, Sixth Edition
- Biology, Sixth Edition
- Biomolecular Free Radical Toxicity: Causes and Prevention
- Cell and Molecular Biology: Concepts and Experiments
- Chemistry: The Molecular Nature of Matter and Change
- Chronobiology: Biological Timekeeping
- Cracking the AP Biology Exam, 2006-2007 Edition (College Test Prep)
- Developing Your Own Psychic Powers
- Developmental Genetics of the Flower, Volume 44: Advances in Botanical Research
- Discovering Genomics, Proteomics and Bioinformatics (2nd Edition) (The Genetics Place Series)
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One Renegade Cell (Science Masters)
