Biomolecular Free Radical Toxicity: Causes and Prevention

Book Description

Biomolecular Free Radical Toxicity: Causes and Prevention provides a comprehensive overview of biomolecular injury. By discussing recent research and providing interpretations of the available data, this unique and timely book explores the causes of biomolecular injury and the possible routes to its prevention. Split into three sections, the book covers:

macromolecular mechanisms of injury and the role of antioxidants;
gene expression and cell mediated mechanisms of toxicity expression; and,
human and environmental health effects.

Written by experts in the field, Biomolecular Free Radical Toxicity: Causes and Prevention will be invaluable to researchers specialising in food and nutrition-based toxicology, biomolecular sciences, biochemistry, genetics, environmental biomonitoring, drug metabolism and carcinogenesis.

Book Description

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition · Updated chapters · Types of toxic responses · Disruption of signal transduction by xenobiotics · Disruption of mitochondrial function · Novel mechanisms derived from systems toxicology

Customer Reviews:

Advanced Undergrad to Beginning Grad Student Level.......2007-05-29

This book is specialized to one particular area of toxicology, the mechanisms by which tocic substances work. It focuses on the general principles that link xenobiotic-induced toxicity with molecular pathways undelying those toxic effects. It includes many examples using drugs, environmental pollutants and other chemicals.

In the five years since the first edition was published there have been majot advances in virtually every aspect of the field. As a result each chapter has been updated and new chapters added.

Although an introductory book on the subject, this book is intended for the advanced undergraduate or beginning graduate level student. Of course it might also be used by specialists in other areas needing information about the subject. To further this usage, there is an extensive bibliography of papers at the end of each chapter.

Amazing Mechanistic.......2006-03-24

The book arrived quickly and was perfect. It was so much more reasonably priced than at school.

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Molecular Toxicology
P. David Josephy , and Bengt Mannervik
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195176200

Book Description

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things at the molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair, among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses, as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Sunscreen Photobiology : Molecular, Cellular, and Physiological Aspects (Biotechnology Intelligence Unit) (Biotechnology Intelligence Unit)

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I never knew!
great winter reading for general scientific audience

Sunscreen Photobiology : Molecular, Cellular, and Physiological Aspects (Biotechnology Intelligence Unit) (Biotechnology Intelligence Unit)

Manufacturer: Springer Verlag
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540632514

Book Description

Sunscreens are universally recommended by dermatologists not only to prevent the immediate effects of overexposure to sunlight but also to prevent skin cancer. While the former goal is immediately evident, the latter remains an unproven hypothesis and is a topic of some controversy. Recent epidemiological studies suggesting a correlation between increased use of sunscreens over the past two decades and the rise in skin cancer have led to the question whether sunscreens applied to skin may be undergoing photoreactions, the effects of which are elaborated many years later. By addressing the key questions, this book advances the field of sunscreen photobiology and provides the reader with an unbiased perspective on this important field.

Customer Reviews:

I never knew!.......1999-07-08

This is an amazing breakthrough book

great winter reading for general scientific audience.......1997-12-03

I am the author - a struggling research scientist - please buy my book! Seriously this book is about a new field of scientific research - sunscreen photobiology - what is that? Photobiology is the science of the effect of light on living matter. In this book experts describe the effects of sun light (natural and artificial) on sunscreens as well as the effects of the light that penetrates sunscreen protected skin and reaches the underlying cells (after after all sunscreens are not concrete blocks!)

Average customer rating:

Notes from an Oxymoron
Notes from an Oxymoron
An excellent book for scientists

Free Radicals in Biology and Medicine
Barry Halliwell , and John Gutteridge
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 019856869X

Book Description

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research since its first publication in 1985. This latest edition has been comprehensively rewritten and updated (over 80% of the text is new), whilst maintaining the clarity of its predecessor. There is expanded coverage of isoprostanes and related compounds, mechanisms of oxidative damage to DNA and proteins (and the repair of such damage), the free radical theory of ageing and the roles played by reactive species in signal transduction, cell death, human reproduction, and other important biological events. Greater emphasis has also been placed on the methods available to measure reactive species and oxidative damage (and their potential pitfalls), as well as the importance of antioxidants in the human diet. This book is recommended as a comprehensive introduction to the field for students, clinicians and researchers, and an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Customer Reviews:

Notes from an Oxymoron.......2001-09-25

Excellent book that provides a thorough grounding to the field. Keep the updated editions coming every few years and it will continue to stay at the top.

Notes from an Oxymoron.......2001-09-25

Excellent book that provides a thorough grounding to the field. Keep the updated editions coming every few years and it will continue to stay at the top.

An excellent book for scientists.......2000-05-29

Free radical biology has become a big research area. This text is definitely a helpful tool for students and professionals alike. Halliwell and Gutteridge are both the "authorities" in free radical research. The book contains the basic concepts of metabolism, metal interactions, free radical formation, and antioxidation. The book then relates these processes (that is, oxidative and nitorsative stresses) to pathological events using various disease paradigms. The text contains good illustrations. It is an excellent reference material for everyone who is entering the field of free radical biology and medicine.

Medicinal Chemistry: A Molecular and Biochemical Approach

Average customer rating:

Better than Goodman and Gilman for pharmacy students

Medicinal Chemistry: A Molecular and Biochemical Approach
Thomas Nogrady , and Donald F. Weaver
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0195104560

Book Description

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and biochemical principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and exogenous pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Customer Reviews:

Better than Goodman and Gilman for pharmacy students.......2002-01-18

I have taken two pharmacological type classes. One was pharmacology and the other was simply med chem. We used Goodman and Gilman in the pharmacology class and its just too dense. It has much information, but in my opinion, its not appropriate for a textbook. I thought that this book, by Nogrady is alot more managable. However, you need to have a background in biochemistry and organic chemistry to understand some of the topics in this book. It does a good job of explaining underlying mechanisms of pharmaceutical actions. Towards the end, it adopts a Goodman and Gilman approach and just starts listing drugs and their mechanism of action. However, Nogrady doesn't go on for 5 pages like Goodman and Gilman do. Its a bit more concise. Anyway, I don't mean to say that Goodman and Gilman is a bad book, quite the contrary, its an amazing book with more information than one could ever possibly want. Its just that if you want to understand pharmacology for a class, and are not browsing the pages for fun over a cup of tea, Nogrady may be the way to go.

Drug Metabolism and Transport: Molecular Methods and Mechanisms (Methods in Pharmacology and Toxicology)

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Drug Metabolism and Transport: Molecular Methods and Mechanisms (Methods in Pharmacology and Toxicology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588293246

Book Description

A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.

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Flow Cytometry for Biotechnology

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195183142

Book Description

Flow cytometry is a sensitive and quantitative platform for the measurement of particle fluorescence. In flow cytometry, the particles in a sample flow in single file through a focused laser beam at rates of hundreds to thousands of particles per second. During the time each particle is in the laser beam, on the order of ten microseconds, one or more fluorescent dyes associated with that particle are excited. The fluorescence emitted from each particle is collected through a microscope objective, spectrally filtered, and detected with photomultiplier tubes. Flow cytometry is uniquely capable of the precise and quantitative molecular analysis of genomic sequence information, interactions between purified biomolecules and cellular function. Combined with automated sample handling for increased sample throughput, these features make flow cytometry a versatile platform with applications at many stages of drug discovery. Traditionally, the particles studied are cells, especially blood cells; flow cytometry is used extensively in immunology. This volume shows how flow cytometry is integrated into modern biotechnology, dealing with issues of throughput, content, sensitivity, and high throughput informatics with applications in genomics, proteomics and protein-protein interactions, drug discovery, vaccine development, plant and reproductive biology, pharmacology and toxicology, cell-cell interactions and protein engineering.

Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)

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Apoptosis Methods in Pharmacology and Toxicology: Approaches to Measurement and Quantification (Methods in Pharmacology and Toxicology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Book Description

Dr. Myrtle A. Davis has assembled a panel of cutting-edge scientists to describe their best methods for detecting, illuminating, and quantifying apoptotic mechanisms in a way that is useful for the design of toxicology and pharmacology studies. These state-of-the-art techniques include flow cytometric, fluorometric, and laser scanning methods for quantifying and characterizing apoptosis, as well as protocols for the use of DNA microarray technology, high throughput screens, and ELISA. Immunocytochemical methods for measuring biochemical and molecular endpoints in tissue sections will be highly useful for those carrying out studies in whole animal models as opposed to cell culture systems.

Advances in Molecular Toxicology, Volume 1

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Advances in Molecular Toxicology, Volume 1

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

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ASIN: 0444528423

Book Description

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed.

* Cutting edge reviews by leading workers in the discipline.
* In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines.
* Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

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