A Statistical Approach to Genetic Epidemiology: Concepts and Applications

Book Description

Covering the latest developments, this advanced textbook is the first to focus on introducing the relevant statistical methods applied in this field. Written by the prize-winning scientist Andreas Ziegler, President of the German Region of the International Biometric Society, and Inke König, who contributes more than five years of teaching experience, this is ideal for epidemiologists, geneticists, statistics specialists, biomathematicians, and graduate students.
After providing a concise introduction to genetic fundamentals, the authors explain both linkage analysis and association analysis in detail. The textbook features more than 100 problems and solutions.
With a foreword by Robert C. Elston, Director, Division of Genetic and Molecular Epidemiology at the Case Western Reserve University, Cleveland, Ohio.

Disease Evolution: Models, Concepts, and Data Analyses (Dimacs Series in Discrete Mathematics and Theoretical Computer Science)

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Disease Evolution: Models, Concepts, and Data Analyses (Dimacs Series in Discrete Mathematics and Theoretical Computer Science)

Manufacturer: American Mathematical Society
ProductGroup: Book
Binding: Hardcover

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ASIN: 0821837532

Book Description

Infectious diseases are continuing to threaten humankind. While some diseases have been controlled, new diseases are constantly appearing. Others are now reappearing in forms that are resistant to drug treatments. A capacity for continual re-adaptation furnishes pathogens with the power to escape our control efforts through evolution. This makes it imperative to understand the complex selection pressures that are shaping and reshaping diseases. Modern models of evolutionary epidemiology provide powerful tools for creating, expressing, and testing such understanding.

Bringing together international leaders in the field, this volume offers a panoramic tour of topical developments in understanding the mechanisms of disease evolution. The volume's first part elucidates the general concepts underlying models of disease evolution. Methodological challenges addressed include those posed by spatial structure, stochastic dynamics, disease phases and classes, single- and multi-drug resistance, the heterogeneity of host populations and tissues, and the intricate coupling of disease evolution with between-host and within-host dynamics. The book's second part shows how these methods are utilized for investigating the dynamics and evolution of specific diseases, including HIV/AIDS, tuberculosis, SARS, malaria, and human rhinovirus infections.

This volume is particularly suited for introducing young scientists and established researchers with backgrounds in mathematics, computer science, or biology to the current techniques and challenges of mathematical evolutionary epidemiology.

Book Description

Genetic Dissection of Complex Traits will present the full range of methodologies that are essential for understanding the basis of human genetic disorders, the origin of such diseases, and theories on how to determine one's genetic predisposition to certain genetic diseases.

Customer Reviews:

great collection of statistical genetic techniques.......2002-05-23

This book is great because it covers all the bases in statistical genetics and features authors who are some of the founders in the field. My favorite chapter is on the Newton Morton number - mine is 2 :) Definitely a good read for anyone interested in a growing field.

Collection of Genetic Epidemiological Developments.......2001-02-21

There has been a lot of development of novel statistical methods in the last decade which has resulted in a better understanding of genetic disorders. There are not many existing books on the subject. This volume is a collection of excellent papers written by some of the renowned experts in the field. The papers range from the basic concepts in genetic epidemiology to applications of some of the most recently developed statistical techniques like CART . The precautions that one needs to take while analyzing genetic data have also been addressed in details. The final chapter by Newton Morton is a treat to read and provides a great overview of the future directions in the field. Overall the book will be very helpful to all genetic epidemiologists in their research.

Fractals and Chaos Simplified for the Life Sciences

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Fractals and Chaos Simplified for the Life Sciences
Larry S. Liebovitch
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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Fractal Geometry in Biological Systems: An Analytical Approach

ASIN: 0195120248

Book Description

Fractals and chaos are currently generating excitement across various scientific and medical disciplines. Biomedical investigators, graduate students, and undergraduates are becoming increasingly interested in applying fractals and chaos (nonlinear dynamics) to a variety of problems in biology and medicine. This accessible text lucidly explains these concepts and illustrates their uses with examples from biomedical research. The author presents the material in a very unique, straightforward manner which avoids technical jargon and does not assume a strong background in mathematics. The text uses a step-by-step approach by explaining one concept at a time in a set of facing pages, with text on the left page and graphics on the right page; the graphics pages can be copied directly onto transparencies for teaching. Ideal for courses in biostatistics, fractals, mathematical modeling of biological systems, and related courses in medicine, biology, and applied mathematics, Fractals and Chaos Simplified for the Life Sciences will also serve as a useful resource for scientists in biomedicine, physics, chemistry, and engineering.

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Handbook of Biosurveillance: Helpful Book for Public Health, ICPs

Handbook of Biosurveillance

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0123693780

Book Description

Provides a coherent and comprehensive account of the theory and practice of real-time human disease outbreak detection, explicitly recognizing the revolution in practices of infection control and public health surveillance.

*Reviews the current mathematical, statistical, and computer science systems for early detection of disease outbreaks
*Provides extensive coverage of existing surveillance data
*Discusses experimental methods for data measurement and evaluation
*Addresses engineering and practical implementation of effective early detection systems
*Includes real case studies

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Handbook of Biosurveillance: Helpful Book for Public Health, ICPs.......2006-09-07

A valuable book, published earlier this year, provides a practical, comprehensive examination of biosurveillance--the systematic process of data collection and analysis for the purposes of detecting and characterizing outbreaks of disease in humans and animals in a timely manner.

The Handbook of Biosurveillance, by Michael Wagner, Andrew Moore, and Ron Aryel (Elsevier Inc., 2006), can greatly benefit its target audience of epidemiologists, health directors and authorities, infection control practitioners, researchers and IT professionals at organizations that conduct biosurveillance. Wagner and Moore are well known in the biosurveillance and academic communities; they led the team of software developers at the University of Pittsburgh and Carnegie Mellon University who, with funding from the Department of Homeland Security, created the Real-Time Outbreak and Disease Surveillance (RODS) system, now successfully used in 12 of the U.S. states, Canada and Taiwan.

The Handbook of Biosurveillance defines and describes the state-of-the-art in biosurveillance practice and research and is unique in the depth of its coverage of all facets of this emerging discipline. The book offers practical advice for first responders and public health officials as well as an in-depth discussion of the theoretical underpinnings of biosurveillance for researchers. It includes and offers expert advice on how to construct and evaluate biosurveillance systems, assemble and analyze data, and build relationships across organizations. It also includes a section devoted to supporting and improving the decision-making ability of public health authorities and other decision-makers. The book provides a basis for determining when available biosurveillance data supports issuing an alert or not.

For those who have already decided to embrace biosurveillance by constructing surveillance systems, the book can serve as a training manual. It offers the expertise of leading authorities in the standards required by biosurveillance, the micro- and macro-aspects of constructing a system from top to bottom, how to achieve inter-organizational integration, and the legal and ethical requirements of biosurveillance practitioners.

A chapter of the book on project management features a review of collaboration between the RODS Lab and the Tarrant County (Texas) Advanced Practice Center (APC). That effort led to the successful development of a regional surveillance network in North Central Texas. In two years, the network grew from merely an idea to a national model of successful biosurveillance. Today, the network collects and analyzes emergency department chief complaint data from 34 hospitals and three urgent care centers and serves more than 30 public health professionals responsible for ensuring the health of more than 6 million residents in Dallas, Fort Worth and the surrounding communities. The book's project management chapter accurately covers the ways the APC and the RODS Lab worked together in planning, executing, monitoring and controlling the work necessary to bring hospitals onto the network in a logical, effective manner.

The book is worth its $99.95 cost if you might need an insightful collection of practical, how-to information on biosurveillance. The APC wishes the book had been available when it first began research into biosurveillance in 2004. Its contents would have been a gold mine to the APC then - just as it can be today to those seeking either to launch new biosurveillance programs or expand their existing initiatives.

Dean Lampman
[...]

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rare collection of experts in their respective fields
Very fascinating, have referred others to read as well.

Emerging Viruses

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195074440

Book Description

New epidemics such as AIDS and "mad cow" disease have dramatized the need to explore the factors underlying rapid viral evolution and emerging viruses. This comprehensive volume is the first to describe this multifaceted new field. It places viral evolution and emergence in a historical context, describes the interaction of viruses with hosts, and details the advances in molecular biology and epidemiology that have provided the tools necessary to track developing viral epidemics and to detect new viruses far more successfully than could be done in the recent past. This unique book also lucidly details case histories and offers practical suggestions for the prevention of future epidemics. The contributors are leading authorities in their disciplines, and were selected both for their expert knowledge and for their ability to define and elucidate the fundamental issues. The book is highly accessible and has been written for a wide audience that includes virologists, public health authorities, medical anthropologists, evolutionary biologists, geneticists, infectious disease specialists, and social scientists interested in medical and helath issues.

Customer Reviews:

rare collection of experts in their respective fields.......2000-08-04

This book presents different aspects of epidemiology, and virology in each of the chapters. The author and many contributors are THE best people in their field and this book offers a rare opportunity in that their comments are in one easily readable volume. I have spent much time looking for the same information presented here, my research always revealed that the contributors to this volume are the prominent figures for their respective chapters. An excellent book, great value for money

Very fascinating, have referred others to read as well........1999-11-19

I finished reading this fascinating book, and I have highly recommend this book to some of my collegues in the biotech industry. Gives incredible insight for which many people would find interesting and thought provoking. Also, I would someday like to contact the author and compliment him and maybe ask one or two questions about the book.

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handbook of epidemiology edited by wolfgang ahrens iris pigeot

Handbook of Epidemiology

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 3540005668

Book Description

The Handbook of Epidemiology provides a comprehensive overview of the field and thus bridges the gap between standard textbooks of epidemiology and dispersed publications for specialists that have a narrowed focus on specific areas. It reviews the key issues and methodological approaches pertinent to the field for which the reader pursues an expatiated overview. It thus serves both as a first orientation for the interested reader and as a starting point for an in-depth study of a specific area as well as a quick reference and recapitulatory overview for the expert. The book includes topics that are usually missing in standard textbooks and that are only marginally represented in the specific literature as well as innovative areas, e.g. molecular epidemiology, ethical aspects, practical field work, health systems research, quality control, and good epidemiological practice. Each chapter is written by one or more leading scientists and represents the state-of-the-art knowledge.

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handbook of epidemiology edited by wolfgang ahrens iris pigeot.......2006-06-22

handbook of epidemiology edited by wolfgang ahrens iris pigeot

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Excellent reference text

The Biology of Disease Vectors

Manufacturer: University Press of Colorado
ProductGroup: Book
Binding: Hardcover

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ASIN: 0870814117

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Excellent reference text.......2006-03-17

As a PhD student in vector borne infectious diseases, I have found this book incredibly helpful. The text is interesting, timely, and easy to read. It is one of the most comprehensive, insightful reference texts out today. If you are a student interested in infectious disease, entomology, parasitology, or medicine, this book is a "must have."

Molecular Epidemiology: Principles and Practices

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Molecular Epidemiology: Principles and Practices

Manufacturer: Academic Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0126323461

Book Description

This groundbreaking work, now available in paperback, has helped to shape the emerging discipline of molecular epidemiology. Molecular Epidemiology has proven useful to epidemiologists unfamiliar with the terminology and techniques of molecular biology as well as to the molecular biologist working to understand the determinants of human disease and to use that information to control disease. This book demonstrates how molecular epidemiology utilizes the same paradigm as traditional epidemiology in addition to using biological markers to identify exposure, disease, or susceptibility.

Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives

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Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 1566705967

Book Description

The end of the 20th century brought with it a revolution in molecular biology that culminated in advances such as the completion of the human genome. This has brought optimism to the fields of toxicology and environmental health, and the anticipation that molecular biomarkers might soon come of age and have a major impact on human and environmental health. Biomarker research is an area of current interest to scientists in a number of fields that are concerned with environmental exposure to pollutants and environmentally associated disease. Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives provides comprehensive coverage of the current status and future prospects of a field that will play a key role in emerging areas of public health and medicine. It focuses on the risk to human and environmental health of exposure to persistent organic pollutants, heavy metals, airborne toxics, environmental estrogens, and other environmental pollutants. This material will aid researchers in understanding, treating, and preventing environmentally induced disease. Validated molecular biomarkers have long been recognized as invaluable tools for identifying and preventing human disease. As biomarkers begin to be applied more widely, it is also important to assure that they are implemented ethically, with attention to the social and legal issues associated with their use. Biomarkers of Environmentally Associated Disease is an outstanding resource providing state-of-the-art information for the fields that encompass molecular biomarkers.

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