Book Description
iGenetics: A Mendelian Approach reflects the dynamic nature of modern genetics by emphasizing an experimental, inquiry-based approach with a solid treatment of many research experiments.
1. Genetics: An Introduction, Mendelian Genetics, Chromosomal Basis of Inheritance, Extensions of Mendelian Genetic Principles, Quantitative Genetics, Gene Mapping in Eukaryotes, Advanced Gene Mapping in Eukaryotes, Variations in Chromosome Structure and Number, Genetics of Bacteria and Bacteriophages, DNA: The Genetic Material, DNA Replication, Gene Control of Proteins, Gene Expression: Transcription, Gene Expression: Translation, DNA Mutation, DNA Repair, and Transposable Elements, Recombinant DNA Technology, Applications of Recombinant DNA Technology, Genomics, Regulation of Gene Expression in Bacteria and Bacteriophages, Regulation of Gene Expression in Eukaryotes, Genetic Analysis of Development, Genetics of Cancer, Non-Mendelian Inheritance, Population Genetics, Molecular Evolution
For all readers interested in learning the central concepts of genetics.
Customer Reviews:
Genetics is interesting, but this book makes me dread the subject........2007-03-16
The most useful features in this book are "analytical approaches to solving genetics problems" and "questions and problems" at the end of each chapter. Many of the pictures and diagrams are also nice.
However, the writing style tends to be rather dreary and over wordy, which is great for insomniacs, but horrible for those who actually want to learn something. Most of the material is presented in a manner best "learned" by memorization, rather than understanding. As seems to be typical of many biology texts, the "what" is emphasized over the "how" and "why". The sections that approach genetics from a molecular level tend to be better than the others, but the writing style is still too verbose.
Probabilities are treated in a fast and loose manner, but I am willing to concede that such use may be common among geneticists.
I also found several errors and typos in many of the chapters.
I tend to find genetics intrinsically interesting and this book could be worse, but if my only exposure to genetics were through this book, I would probably like the field about as much as I would like to work with potassium cyanide.
Good Text Book.......2005-09-28
I think this is one of my favorite text books that I've encountered to this point. It's wonderfully straight forward and has beautiful diagrams that clearly illustrate the subjects being taught. It's also very nice reading, which is more than I can say about most text books!
Average customer rating:
- would not recommend
- Good overview of molecular evolution studies but a bit outdated
- Nice figures
- Trees and more trees
- Handy read
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Molecular Evolution: A Phylogenetic Approach
Roderic D. Page , and
Edward C. Holmes
Manufacturer: Blackwell Publishing Limited
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Phylogenetic Trees Made Easy: A How-to Manual, Third Edition
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Inferring Phylogenies
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Molecular Evolution and Phylogenetics
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The Phylogenetic Handbook: A Practical Approach to DNA and Protein Phylogeny
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Fundamentals of Molecular Evolution
ASIN: 0865428891 |
Customer Reviews:
would not recommend.......2007-03-26
We use this book in the class and most of us don't like it. The book just doesn't do a good job explaining many things. Unless you are an expert in the field or at least have prior experience I would not recommend you this book.
Good overview of molecular evolution studies but a bit outdated.......2006-03-16
If you're not familiar with DNA sequences analysis and inferring phylogenies, this book is a must read (as far as I know the only introduction book to the field). But it's a bit outdated (Bayesian analysis not covered).
Nice figures.......2004-01-08
I'm new to molecular evolution and have been confused with various terms and concepts (e.g., cladogram vs. phylogram vs. dendrogram, plesiomorphy vs. apomorphy vs. autapomorphy vs. synapomorphy vs. homoplasy, etc.). Reading other books that try to explain these concepts mostly in words only added more confusion.
Every page in this book contains highly illustrative figures that accompanies well written text. Of course, not all sections are not immediately clear to understand, and I would need to read other books as well.
If you are new to molecular evolution, start with this book along with any other books that may suit your particular need.
Trees and more trees.......2000-11-27
Although molecular phylogenetic analysis can be extremely complex, this reference provides an introduction to the subject that is straightforward to read. The reference begins with consideration of trees, which are structures used to model actual evolutionary relationships between genes or entire lifeforms. It then provides an introduction to molecular and population genetics. Coding as well as noncoding DNA (tandem repeats, transposable elements, retroviruses, spacer DNA) is considered. The reference then considers how genetic change can be measured, followed by how we can deduce molecular phylogenies. The validity of the molecular clock is then considered, along with a discussion of the neutralist-selectionist debate. The reference finally considers how different phylogenies can be combined to determine actual phylogeny, reconciled trees, and rates of diversification.
Handy read.......2000-03-25
This book is very well written and a handy tool for anyone who is new to molecular evolution. Nice diagrams and concise chapters. The authors know how to break up the sometimes demanding ideas into appropriate bites. Perfect for grad students and senior undergrads.
Book Description
Covering the latest developments, this advanced textbook is the first to focus on introducing the relevant statistical methods applied in this field. Written by the prize-winning scientist Andreas Ziegler, President of the German Region of the International Biometric Society, and Inke König, who contributes more than five years of teaching experience, this is ideal for epidemiologists, geneticists, statistics specialists, biomathematicians, and graduate students.
After providing a concise introduction to genetic fundamentals, the authors explain both linkage analysis and association analysis in detail. The textbook features more than 100 problems and solutions.
With a foreword by Robert C. Elston, Director, Division of Genetic and Molecular Epidemiology at the Case Western Reserve University, Cleveland, Ohio.
Average customer rating:
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Primary Immunodeficiency Diseases: A Molecular & Cellular Approach
Hans D. Ochs ,
C. I. Edward Smith , and
Jennifer M. Puck
Manufacturer: Oxford University Press, USA
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ASIN: 019514774X |
Book Description
The second edition of Primary Immunodeficiency Diseases presents discussions of gene identification, mutation detection, and clinical and research applications for over 100 genetic immune disorders--disorders featuring an increased susceptibility to infections and, in certain conditions, an icreased rate of malignancies and autoimmune disorders. Since the publication of the first edition, a flurry of new disease entities has been defined and new treatment regimens have been introduced, the most spectacular being successful treatment by gene therapy for two genotypes of combined immunodeficiency. The first edition marked a historic turning point in the field of immunodeficiencies, demonstrating that many of the disorders of the immune systam could be understood at a molecular level. This new edition can proudly document the tremendous pace of progress in dissecting the complex immunologic networks responsible for protecting individuals from these disorders.
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Induced Resistance for Plant Defence a Sustainable Approach to Crop Protection
Walters
Manufacturer: Blackwell Publishing Limited
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ASIN: 140513447X |
Book Description
Plant diseases worldwide are responsible for billions of dollars worth of crop losses every year. With less agrochemicals being used and less new fungicides coming on the market due to environmental concerns, more effort is now being put into the use of genetic potential of plants for pathogen resistance and the development of induced or acquired resistance as an environmentally safe means of disease control.This comprehensive book examines in depth the development and exploitation of induced resistance. Chapters review current knowledge of the agents that can elicit induced resistance, genomics, signalling cascades, mechanisms of defence to pests and pathogens and molecular tools. Further chapters consider the topical application of inducers for disease control, microbial induction of pathogen resistance, transgenic approaches, pathogen population biology, trade offs associated with induced resistance and integration of induced resistance in crop protection. The book concludes with a consideration of socio-economic drivers determining the use of induced resistance, and the future of induced resistance in crop protection.
Book Description
A unique book that integrates knowledge from a wide range of expertise, specifically applied to the mouse, and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: APA covers all aspects of using the mouse as a genetic model organism: care and husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; and gene targetting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.
Book Description
Cytogenetics is concerned with matching inherited traits with the appearance, structure, and behavior of chromosomes. The first volume, Human Cytogenetics: Constitutional Analysis, covers all aspects of basic human cytogenetic study other than malignancies and acquired abnormalities. The
second volume, Human Cytogenetics: Malignant and Acquired Abnormalities, describes the techniques used to study how chromosomal rearrangements can cause malignancies.
Average customer rating:
- Terrible
- the worst book I have ever read
- Could have been a great one.
- An excellent book.
- A very bad book. A colection of references w/o explanations
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Bioinformatics: The Machine Learning Approach, Second Edition (Adaptive Computation and Machine Learning)
Pierre Baldi , and
Søren Brunak
Manufacturer: The MIT Press
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ASIN: 026202506X |
Book Description
An unprecedented wealth of data is being generated by genome sequencing projects and other experimental efforts to determine the structure and function of biological molecules. The demands and opportunities for interpreting these data are expanding rapidly. Bioinformatics is the development and application of computer methods for management, analysis, interpretation, and prediction, as well as for the design of experiments. Machine learning approaches (e.g., neural networks, hidden Markov models, and belief networks) are ideally suited for areas where there is a lot of data but little theory, which is the situation in molecular biology. The goal in machine learning is to extract useful information from a body of data by building good probabilistic models--and to automate the process as much as possible.
In this book Pierre Baldi and Søren Brunak present the key machine learning approaches and apply them to the computational problems encountered in the analysis of biological data. The book is aimed both at biologists and biochemists who need to understand new data-driven algorithms and at those with a primary background in physics, mathematics, statistics, or computer science who need to know more about applications in molecular biology.
This new second edition contains expanded coverage of probabilistic graphical models and of the applications of neural networks, as well as a new chapter on microarrays and gene expression. The entire text has been extensively revised.
Customer Reviews:
Terrible.......2006-03-16
I'm a graduate student, reading a lot of bioinformatics materials. This is by far the worst text I've read on the subject. Poorly explained, poorly edited. Poor.
the worst book I have ever read.......2005-11-06
Just a collection of formulae, in an unclear way. Once we tried to use it in our seminar of bioinformatics, but after a few chapters we had to give it up for its bad writing. I could not find any reason to buy it or read it.
Could have been a great one........2003-12-14
This book is decidedly a mix: some very good information, combined with some very puzzling omissions and uneven editing.
First, the good. The description of stochastic context free grammars is the best I've seen. I don't know any other reference that even hint at how to use generative grammars to evaluate likelihoods. Once they caught my interest, though, the authors did not carry through with training and evaluation algorithms I could really use. I suspect that parts of the information are there, but I'll have to go back over their opaque notation again to work out just what they've given and just what's been left out.
This same pattern - an interesting introduction with missing or mysterious development - recurs throughout the book. The discussion on clustering and phylogeny goes the same way: a number of techniques are mentioned but not developed. The authors mention a tree drawing problem, not just building the tree's topology, but ordering the branches for the most informative rendering. Again, a critical topic and one that most authors miss - in the end, these authors miss it, too, by mentioning but not filling in the idea.
Their discussion of neural nets suffers badly from the authors' partial presentation. Evaluation of network output for a given input is relatively straightforward, and they present it in some detail. Training the net is the real problem, though, and is given less than a page.
Baldi and Brunak give more of the fundamentals than most authors. For example, they explain the maximum entropy principle well enough that I'll use it in lots of other areas. They give some coverage to topics of intermediate complexity, such as the forward and backward algorithms for HMM training. Finally, they fizzle out at the higher levels of complexity - the Baum-Welch algorithm could have followed from the forward and backward methods, but is left as a reference to another book.
There is some good here, especially in the fundamentals behind important techniques. The discussions I wanted - the more avanced topics, in forms I can use - are often weak, missing, or impenetrable. Just a bit more work, clearly within the authors' capability, would have made this a landmark reference.
An excellent book........2001-10-23
Very well written, clear, and self-contained. The authors provide a masterly treatment of machine learning methods (neural networks, hidden markov models, etc.) and their applications to fundamental problems in sequence analyis and biology. The book goes all the way from first principles to advanced research topics and should be valuable for both students and researchers. Second edition has many new topics, including DNA microarrays. Requires some concentration but mathematical details are summarized in the appendices. I strongly recommend it for anyone with an interest in bioinformatics and/or machine learning.
A very bad book. A colection of references w/o explanations.......2001-09-19
I just bought this book and am COMPLETEly disappointed with it.
Here is why. The book is badly written, hard to read and follow. Although it is said that this is a book is for " many readers", it is really for those who have already known all the algorithms. It is simply impossible to learn the algorithms from this book. The chapter on neural network is a few pages. It provieds a few equations for backpropagation. That is it! It is pretty much true for every thing else. Equations, hard to understand sentences, abbreviations with no explnantions, tons of citations everywhere. A book should strive to explain, and not to cite what other papers and go look there all the time. I suspect the few good reviews here are from the authors themselves.
I have a good programming background. I also read some papers on neural network and hidden markov models, This book is a lot worse than anything I have read in explaining the stuff. Very disappointed. Save your money and get something else.
Book Description
iGenetics: A Molecular Approach reflects the dynamic nature of modern genetics by emphasizing an experimental, inquiry-based approach with a solid treatment of many research experiments.
Genetics: An Introduction, DNA: The Genetic Material, DNA Replication, Gene Control of Proteins, Gene Expression: Transcription, Gene Expression: Translation, DNA Mutation, DNA Repair, and Transposable Elements, Recombinant DNA Technology, Applications of Recombinant DNA Technology, Genomics, Mendelian Genetics, Chromosomal Basis of Inheritance,Extensions of Mendelian Genetic Principles, Quantitative Genetics, Gene Mapping in Eukaryotes, Advanced Gene Mapping in Eukaryotes, Variation in Chromosome Number and Structure, Genetic Analysis of Bacteria and Bacteriophages, Regulation Of Gene Expression In Bacteria And Bacteriophages, Regulation Of Gene Expression In Eukaryotes, Genetic Analysis Of Development, Genetics Of Cancer, Non-Mendelian Inheritance, Population Genetics, Molecular Evolution.
For all readers interested in learning the central concepts of genetics.
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Gene Targeting: A Practical Approach
Manufacturer: Oxford University Press, USA
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Manipulating the Mouse Embryo: A Laboratory Manual
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Mouse Genetics and Transgenics: A Practical Approach
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Mouse Phenotypes: A Handbook of Mutation Analysis
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Gene Knockout Protocols (Methods in Molecular Biology)
ASIN: 019963792X |
Book Description
Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first chapter covers the design of gene targeting vectors for mammalian cells and describes how to distinguish random integrations from homologous recombination. It is followed by a chapter on extending conventional gene targeting manipulations by using site-specific recombination using the Cre-loxP and Flp-FRT systems to produce 'clean' germline mutations and conditionally (in)activating genes. Chapter 3 describes methods for introducing DNA into ES cells for homologous recombination, selection and screening procedures for identifying and recovering targeted cell clones, and a simple method for establishing new ES cell lines. Chapter 4 discusses the pros and cons or aggregation versus blastocyst injection to create chimeras, focusing on the technical aspects of generating aggregation chimeras and then describes some of the uses of chimeras. The next topic covered is gene trap strategies; the structure, components, design, and modification of GT vectors, the various types of GT screens, and the molecular analysis of GT integrations. The final chapter explains the use of classical genetics in gene targeting and phenotype interpretation to create mutations and elucidate gene functions. Gene Targeting: A Practical Approach 2e will therefore be of great value to all researchers studying gene function.
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- Introduction to General, Organic and Biochemistry (with CD-ROM and ThomsonNOW Printed Access Card)
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