Book Description
The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability.
Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance.
Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.
Average customer rating:
- Adequate for the student of pharmacy
- Excellent Work
|
Foye's Principles of Medicinal Chemistry
David A Williams ,
William O Foye ,
Thomas L Lemke , and
William O. Foye
Manufacturer: Lippincott Williams & Wilkins
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Goodman & Gilman's The Pharmacological Basis of Therapeutics (Goodman and Gilman's the Pharmacological Basis of Therapeutics)
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Review of Organic Functional Groups: Introduction to Medicinal Organic Chemistry
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Pharmacotherapy
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Handbook of Nonprescription Drugs
ASIN: 0683307371 |
Book Description
This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
Customer Reviews:
Adequate for the student of pharmacy.......2006-11-03
Well written and adequate for the student of pharmacy. However for this audience I would recommend Wilson and Gisvold's Textbook of Organic Medicinal and Pharmaceutical chemistry 11th Ed, because the figures and text are more complete providing a clearer more concise and rigorous treatment of the subject.
Excellent Work.......2004-11-09
There are no words to discribe it !!!! It is for scientists who want to know how things work with drugs . A number of tables and figures with drugs and their chemical structure make the difference . I think it worth the cost .
Book Description
In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs.
While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.
Book Description
The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding.
Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed.
An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Customer Reviews:
Great book.......2003-11-18
This is a nice book, not so long, compact! with all the references needed for who is doing protein-structure based drug design!
Luca http://www.abo.fi/~lsettimo
Average customer rating:
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Evolutionary Algorithms in Molecular Design (Methods and Principles in Medicinal Chemistry)
Manufacturer: Wiley-VCH
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ASIN: 3527301550 |
Book Description
When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the 'survival of the fittest', in computer programs designed to search for optimal solutions to many kinds of problems. These 'evolutionary algorithms' start from a population of possible solutions to a given problem and, by applying evolutionary principles, evolve successive generations with improved characteristics until an optimal, or near-optimal, solution is obtained.
This book highlights the versatility of evolutionary algorithms in areas of relevance to molecular design with a particular focus on drug design. The authors, all of whom are experts in their field, discuss the application of these computational methods to a wide range of research problems including conformational analysis, chemometrics and quantitative structure-activity relationships, de novo molecular design, chemical structure handling, combinatorial library design, and the study of protein folding. In addition, the use of evolutionary algorithms in the determination of structures by X-ray crystallography and NMR spectroscopy is also covered.
These state-of-the-art reviews, together with a discussion of new techniques and future developments in the field, make this book a truly valuable and highly up-to-date resource for anyone engaged in the application or development of computer-assisted methods in scientific research.
Book Description
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
Average customer rating:
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Voltage-Gated Ion Channels as Drug Targets (Methods and Principles in Medicinal Chemistry)
Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover
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ASIN: 3527312587 |
Book Description
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology.
After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development.
For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
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Molecular Interaction Fields: Applications in Drug Discovery and ADME Prediction (Methods and Principles in Medicinal Chemistry)
Manufacturer: Wiley-VCH
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ASIN: 3527310878 |
Book Description
This unique reference source, edited by the world's most respected expert on molecular interaction field software, covers all relevant principles of the GRID force field and its applications in medicinal chemistry. Entire chapters on 3D-QSAR, pharmacophore searches, docking studies, metabolism predictions and protein selectivity studies, among others, offer a concise overview of this emerging field. As an added bonus, this handbook includes a CD-ROM with the latest commercial versions of the GRID program and related software.
Book Description
This handbook is the first to address the practical aspects of this novel method. It provides a complete overview of the field and progresses from general considerations to real life scenarios in drug discovery research.
Starting with an introductory historical overview, the authors move on to discuss ligand-based approaches, including 3D pharmacophores and 4D QSAR, as well as the concept and application of pseudoreceptors. The next section on structure-based approaches includes pharmcophores from ligand-protein complexes, FLIP and 3D protein-ligand binding interactions. The whole is rounded off with a complete section devoted to applications and examples, including modeling of ADME properties.
With its critical evaluation of pharmacophore-based strategies, this book represents a valuable aid for project leaders and decision-makers in the pharmaceutical industry, as well as pharmacologists, and medicinal and chemists.
Book Description
BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 1: Principles and Practice
This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred over the past decade and a half in medicinal chemistry and new drug development, this latest edition of Volume 1: Principles and Practice now:
* Covers the latest methods of drug discovery, including such "hot" topics as computational chemistry and peptidomimetrics
* Has added emphasis on preclinical development issues
* Offers the most timely information on a broad range of important regulatory, management, legal, and financial issues
* Features in-depth coverage of important factors in the discovery process, including ADME, toxicity and drug allergy, and clinical trials
* Updates readers on recent advances in the understanding of the structural biology of drug action
* Explores the cutting-edge technologies for drug discovery now in use around the world
* Is more than twice the size of its predecessor
* Brings together contributions by experts in a wide range of related fields from North America and Europe
Customer Reviews:
medicinal chemistry.......1999-12-11
to see the new discovery & practice of bulk dru
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