Protein Crystallography (Molecular Biology Series)

Book Description

Crystallography Made Crystal Clear makes crystallography accessible to readers who have no prior knowledge of the field or its mathematical basis. This is the most comprehensive and concise reference for beginning Macromolecular crystallographers, written by a leading expert in the field. Rhodes' uses visual and geometric models to help readers understand the mathematics that form the basis of x-ray crystallography. He has invested a great deal of time and effort on World Wide Web tools for users of models, including beginning-level tutorials in molecular modeling on personal computers. Rhodes' personal CMCC Home Page also provides access to tools and links to resources discussed in the text. Most significantly, the final chapter introduces the reader to macromolecular modeling on personal computers-featuring SwissPdbViewer, a free, powerful modeling program now available for PC, Power Macintosh, and Unix computers. This updated and expanded new edition uses attractive four-color art, web tool access for further study, and concise language to explain the basis of X-ray crystallography, increasingly vital in today's research labs.

* Helps readers to understand where models come from, so they don't use them blindly and
inappropriately
* Provides many visual and geometric models for understanding a largely mathematical method
* Allows readers to judge whether recently published models are of sufficiently high quality and detail to be useful in their own work
* Allows readers to study macromolecular structure independently and in an open-ended fashion on their own computers, without being limited to textbook or journals illustrations
* Provides access to web tools in a format that will not go out of date. Links will be updated and added as existing resources change location or are added

Customer Reviews:

Crystal Clear.......2007-01-17

The delivery was prompt and in the item was in an excellent condition

Clear, but lack depth and practice problem.......2006-12-07

Crystallography Made Crystal Clear does clearly explain the principles of X-ray Crystallography. I used this book for a graduate class in introductory x-ray crystallography when I deemed that the assigned book for the class, Principles of Protein X-Ray Crystallography, unhelpful.

Crystallography Made Crystal Clear presents the theory behind crystallography in the most straightforward way possible. Whenever possible, concepts are explained in words and by examples instead of with equations. This elimates derivations that are not necessary to understand key concepts.

Although explanations in the book are clear, they are often too brief. The book also does not have any practice problems, which is a major drawback. If you are taking a crystallography class, I would take a look at this book but focus more heavily on the lecture notes and problems from class. Honestly, I haven't found a really good crystallography book, but this one at least is not too confusing.

Clear as a crystal!!!!.......2005-01-30

This book is a good one. Explains every aspect I always want to know about crystallography. In my first class of biochemistry I discover that I really like the macromolecular models, but my biochemistry book doesn't content much information about this subjet. When I discover this book I bought it, and read it, and I must to say that this book explain every aspect of the process of create a molecular model.
After read this book I thinking about to become a crystallographer.

The best introduction to the subject.......2004-06-15

This is the best introduction to crystallography I have ever come across. Which is quite an achievement, because its a difficult subject to understand. In crystallography, its very rare to find a book which does not deal with either a totally descriptive approach or a totally mathematical approach. Rhodes' book bridges the gap between the two and gives the reader the right dose of jargon and explanation. He illustrates every point with plenty of figures as well as real life computer models of proteins. Before I came across this book, I was struggling and failing to understand Isomorphous Replacement, MAD, Solvent Flattening, Maps and Models, as well as the iterative refining of models. I think no other book comes even close to this book in explaining all these concepts in simple format. This, I think is as clear as it can get without becoming oversimplified. A must have for all researchers and students whose work is even remotely connected to crystallography.

"The" clearest one out there...........2003-06-04

When it comes to this field of research, you get two types of references: (1) the 2-5 page quick intro that leaves you with the most basic overview of crystallography and (2) the 'hard core' books that go into such detail as to leave you breathless. This book is, in my opinion, the best transition book.

For non-crystallographers, this book will teach enough about crystallography to allow you to read crystal structure articles and understand what is meant by all of the used statistics and such.

For apprentice crystallographers, this is a wonderful intro into the field. Master the book, then move on to harder books to master it.

Book Description

X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, Dr. Jan Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided an up-to-date and technically rigorous introduction to the subject.

Principles of Protein X-ray Crystallography provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to serve as an introduction for graduate students, postdoctoral researchers, and established scientists who want to use protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. New additions to the book include a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion (SAD).

About the Authors:

Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands.

Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany.

Customer Reviews:

Depends on who you are and what you want..........2007-09-28

Jan Drenth is an old school protein crystallographer who has seen the evolution of the field right from its inception in the 1950s to the present day. He belongs to the era when Protein Crystallography was dominated by people with serious math and physics skills like Maurice Wilkins, Rosalind Franklin, Francis Crick, Max Perutz and John Kendrew. Owing to the lack of good computers in those days, all the calculations had to be done by hand and there was no way you could solve a protein structure if you didn't know what a Fourier Transform was. The situation is very different nowadays where, thanks to computers, even a person who doesn't know how to differentiate a function can solve protein structures.
Understandably, owing to the author's experiences and background, this book is an excellent one for people interested in the real math behind protein crystallography. It is much on the lines of the other classic book by Blundell and Johnson, also crystallographers belonging to the same era as Jan Drenth. It is quite full of mathematics and therefore, is not recommended for biologists or chemists with weak math skills. For such people I would recommend other introductory books on the subject written by Gale Rhodes, David Blow and Alex McPherson. A good approach would be to learn the basics from these intoductory books and 'graduate' to Drenth's book later.

Not Helpful for a introductory class.......2006-12-07

I used this text book for an introductory graduate class in X-ray Crystallograhy. After taking a semester of X-ray Crystallograhy (which is labeled as a Chemistry and Biochemistry course), I can say that the material is mainly based on physics and mathematics. I can't say that this text helped a great deal for my course. The text does not explain relevant points such as Miller indices, symmetry elements, or space groups clearly or in much depth. Instead, it spends too much time explaining concepts mathematically and deriving equations. It also does not contain any relevant practice problems, which are needed to understand Crystallography and practice for exams.

X-ray Crystallography is a very dense subject, and is not a course to take on a whim. I would not reccomend taking a course on Crystallography unless you have a really intense interest in pursuing research in that area. If you are interested in this area, do not buy this text even if it is required for your course. Take a look at Crystallography Made Crystal Clear by Gale Rhodes. That book is much clearer, though also lacks sufficient practice problems.

Decent text, but better Crystallography books are out there........2002-09-16

Drenth is a decent enough book. The figures are ok, nothing great. They mostly just drive home the point made in the text, but are not instructive in and upon themselves. If you are looking to get a basic understanding of X-Ray crystallography and its uses to solve protein structure try the Gale Rhodes book. If you are looking for a more rigorous book try the Michael M. Woolfson book. Drenth tries to be the middle ground between the two. The subject though is too complicated to do it justice like that. Either keep it simple or go in depth.

Best introductory text.......2001-04-17

Best introductory text for macromolecular xray crystallography. Simple and succinct mathematical explanation of basic concepts. It provides enough background for students to start a research project.

Macromolecular Crystallography Protocols, Volume 1: Preparation and Crystallization of Macromolecules (Methods in Molecular Biology)

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Macromolecular Crystallography Protocols, Volume 1: Preparation and Crystallization of Macromolecules (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588292924

Book Description

Macromolecular Crystallography Protocols, now in two volumes, examines major developments that have occurred since publication of the acclaimed first edition nearly a decade ago. Volume 1, Preparation and Crystallization of Macromolecules and Volume 2, Structure Determination, explore recent advances that have accelerated the pace of structural determination and made crystallography accessible to a broader range of investigators.

Volume 1 is composed of detailed protocols for the preparation and optimization of crystals, including tips from the experts on the best methods for inducing proteins to adopt their crystalline form. Volume 2 complements the first volume by addressing laboratory techniques for crystal handling and structural characterization, as well as computational techniques for data collection, phasing, and refinement. The volume concludes with a detailed and insightful survey of available crystallographic software. These volumes will be an indispensable reference for obtaining macromolecular crystals and determining their three-dimensional structure.

Practical Protein Crystallography, Second Edition

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I wish there were more like it!
A book for crystallography newbies!

Practical Protein Crystallography, Second Edition
Duncan E. McRee
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0124860524

Book Description

Designed for easy use by both beginning and experienced protein crystallographers, the second edition of Practical Protein Crystallography is an essential handbook for any scientist interested in solving a protein structure. The book includes examples of actual experiments and data, electron density maps, and computer methods. This second edition has new material covering CCP4, SHELX, cryocrystallography, MAD and automated fitting.

Key Features
* In-depth coverage of every aspect of crystallography
* Coverage of the small details that can make or break projects
* Strongly application-oriented
* Exceptionally well illustrated
* Simple and easy-to-follow robust methods
* Tutorials with actual data available on the Web
* Useful for a broad spectrum of scientists

Customer Reviews:

I wish there were more like it!.......2002-03-13

I discovered this book in my final year of my PhD, and I am so glad I did. It was indispensible to me and a great revision guide in the time leading upto my viva. I am now doing a post doc in protein crystallography and still use it and recommend it to graduate students and undergrads. I just wish that there were more books similar to this one, but going through other protein crystallography programs and showing how to solve structures. This book is mainly for XtalView and SHELX structure solutions, can you write another one on O and CNS & REFMAC structure solutions! Totally worth every penny and have had to buy another copy as the one I had originally has worn away!

A book for crystallography newbies!.......2000-05-03

I'd read the first book, back in my undergrad days and resorted to another to get the overall jist of things for basic understanding. But now that I'm actually a "practicing" crystallographer, I find this book indispensable. McRee explains with both detail and DIRECTION such that not only is the context understandable, but it is USABLE...hence the title of the book. All I could wish for were problems, like solving difference Pattersons and the likes...

Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)

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Protein Crystallography in Drug Discovery (Methods and Principles in Medicinal Chemistry)

Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover

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ASIN: 3527306781

Book Description

The rational, structure-based approach has become standard in present-day drug design. As a consequence, the availability of high-resolution structures of target proteins is more often than not the basis for an entire drug development program. Protein structures suited for rational drug design are almost exclusively derived from crystallographic studies, and drug developers are relying heavily on the power of this method.

Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first time. They discuss strategies to derive high-resolution structures for such important target protein classes as kinases or proteases, as well as selected examples of successful protein crystallographic studies. A special section on recent methodological developments, such as for high-throughput crystallography and microcrystallization, is also included.

Book Description

Proteins play a central role in all biological systems. They fulfill numerous functions which depend upon their complex three-dimensional structures, maintained by a multitude of interactions. This book examines important advances in the understanding of protein structure diversity, the basis
of protein stability, and the important relationship between structure and function. These findings have been made possible through the application of key techniques such as X-ray crystallography, NMR, and protein engineering. Protein Structure: In Focus provides comprehensive coverage of this
subject for students in biochemistry, biophysics, molecular biology, and related courses, and will also be of great interest to researchers requiring an introduction to this field.

Customer Reviews:

All animals are created equal, but some are more..........2006-05-15

...equal than others. (Animal Farm, Orwell)

The three of five stars rating awarded by the earlier reviewer is unjustified, and its repeat appearance unduly biases the rating of this fine text.

It is indeed top flight, and a copy is worth having for almost all devoted students of protein structure, and mechanisms of enzyme action. Moreover, Prof Creighton certainly has something to offer all students in this area, via this text and his other writings, in part for historical reasons, and in part because his instights still clearly obtain. Essentially always, I'd rather read *him* than *ten reviews about him*, and would encourage my students to do the same.

A novice in protein structure.......2000-07-06

This is not a really comprehensive book (it cannot be, with its size), but it is very useful as a quick reference or when you need to refresh the basic concepts of protein structure.

A novice in protein structure.......2000-07-06

This is not a really comprehensive book (it cannot be, with its size), but it is very useful as a quick reference or when you need to refresh the basic concepts of protein structure.

Preparation and Analysis of Protein Crystals

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Preparation and Analysis of Protein Crystals
Alexander McPherson
Manufacturer: Krieger Pub Co
ProductGroup: Book
Binding: Hardcover

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ASIN: 089464355X

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Conformation in Biology
R. Srinivasan
Manufacturer: Adenine Pr
ProductGroup: Book
Binding: Hardcover

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ASIN: 0940030055

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