Enzyme Kinetics and Mechanism

Customer Reviews:

A lot of information, but not-so-well explained..........2005-04-13

With an undergrad degree in chemistry and a year of graduate school (granted, without a focus solely in biochemistry), this text was often difficult for me to follow and gain much from. Though the text contained an impressive breadth of topics, this breadth came at the cost of depth. In my opinion, a textbook should more-or-less stand on its own in providing a clear understanding of a topic. All too often I didn't find this to be the case with the Fersht book. Instead, I often had to consult many of the references listed in the text to obtain sufficient understanding of topics. (Fortunately, the book includes extensive reference lists.) If looking up endless references (many old and sometimes difficult to obtain) is something you enjoy, this book is for you.--If not, forget it!

Highly recommend it.......2003-08-31

Hands down the bible of enzyme kinetics!

Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.

essential.......2002-05-01

If you are studying protein structure, you probably should read this book for reference.

This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.

Some texts are difficult to understand, or dry, or facile. This is not one of those texts.

Biochemists Can't Miss.......2001-08-23

The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.

Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.

Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

The Mother of All Enzyme Books.......2001-01-10

Man, this book rocked! I took one look at the ribbon structure of ATPase on the cover and said to myself, "Whoa dude! This is, like, phat!" Then I turned the pages and BAM! I was knee deep in protein structure! Like, any first-year biochemist knows its all about the acids, as in amino, and Fersht, he knows his peptides! Oh man, I was on cloud nine! And I've been off my meds for two months now! But you wanna know the real dope? You can't say diddly about function unless you know structure, and that Alan, as in Fersht, dude! Like, he starts you off simple, like, you know, with the "building blocks," like we're a bunch of two-year-olds, and you string 'em together and get all that higher-order structure and stuff, and slowly, ever so slowly, like a mental itch that invades your consciousness and becomes screaming voices telling you to AHHHHHHHHH! So many domains! Too many functional units! No, no, nooooooo! Schiff base? Shift Bass! Ah HA HA HA HA! What do all those K's mean!?! Take me home! Please...

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Principles of Combustion
Kenneth Kuan-yun Kuo
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471046892

Book Description

Principles of Combustion, Second Edition is a revision of what was the leading book on combustion engineering. The new edition has been revised to include new theoretical results and measurement techniques of non-intrusive diagnostic methods, contains more material on chemical kinetics during ignition; and is expanded to provide more in-depth treatment of sensitivity analysis and methods for identifying controlling chemical mechanisms. Expanded coverage is combined with the latest results regarding turbulent activity during combustion and the chemical kinetics of flames.

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Enzymatic Reaction Mechanisms
Perry A. Frey , and Adrian D. Hegeman
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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ASIN: 0195122585

Book Description

Books Dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.

Chemical Kinetics and Inorganic Reaction Mechanisms

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Chemical Kinetics and Inorganic Reaction Mechanisms

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Reaction Mechanisms of Inorganic and Organometallic Systems (Topics in Inorganic Chemistry)

ASIN: 0306477475

Book Description

This book is aimed at researchers in the field of inorganic reaction mechanisms. The chemical kinetics portion of the book would be widely applicable in both organic and inorganic chemistry. A third of the book would appeal to graduate students of any chemical subject, such as chemical engineering, pharmaceutical chemistry, and some medical sciences.

The remainder of the book is devoted to inorganic reaction mechanisms and will be of interest to researchers. Compounds which contain metals are of interest not only to inorganic chemists, but to organic chemists and biochemists as well.

Chemical Kinetics and Reaction Mechanisms

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Good intro book
Generally a good book

Chemical Kinetics and Reaction Mechanisms
James H Espenson , and James Espenson
Manufacturer: McGraw-Hill Science/Engineering/Math
ProductGroup: Book
Binding: Paperback

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ASIN: 0072883626

Book Description

This book covers chemical kinetics from the working chemists' point of view. Competing books present a more theoretical presentation of kinetics. This book is a "how to" book for designing experiments, analyzing, and critiquing them. Chemical Kinetics and Reaction Mechanisms also prepares chemists to devise experiments to test different hypotheses. A diskette that helps students solve end-of-chapter problems is packaged with each text.

Customer Reviews:

Good intro book.......2000-12-06

Espenson's book is ok. It's a little difficult to read at times, but covers the basics fairly well. More references would be useful. A good introductory book.

Generally a good book.......2000-11-30

This book has a lot of basic stuff in it. It is rather easy to read and simplistic. It is a good introductory kinetics book, but be prepared to take advantage of other resources in order to accomplish your kinetics task. Not necessarily a great reference book for your graduate studies.

Determination of Complex Reaction Mechanisms: Analysis of Chemical, Biological, and Genetic Networks

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Determination of Complex Reaction Mechanisms: Analysis of Chemical, Biological, and Genetic Networks
John Ross , Igor Schreiber , Marcel O. Vlad , Adam Arkin , Peter J. Oefner , and Nicola Zamboni
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Hardcover

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An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/Crc Mathematical and Computational Biology Series)

ASIN: 0195178688

Book Description

In a chemical system with many chemical species several questions can be asked: what species react with other species: in what temporal order: and with what results? These questions have been asked for over one hundred years about simple and complex chemical systems, and the answers constitute the macroscopic reaction mechanism. In Determination of Complex Reaction Mechanisms authors John Ross, Igor Schreiber, and Marcel Vlad present several systematic approaches for obtaining information on the causal connectivity of chemical species, on correlations of chemical species, on the reaction pathway, and on the reaction mechanism. Basic pulse theory is demonstrated and tested in an experiment on glycolysis. In a second approach, measurements on time series of concentrations are used to construct correlation functions and a theory is developed which shows that from these functions information may be inferred on the reaction pathway, the reaction mechanism, and the centers of control in that mechanism. A third approach is based on application of genetic algorithm methods to the study of the evolutionary development of a reaction mechanism, to the attainment given goals in a mechanism, and to the determination of a reaction mechanism and rate coefficients by comparison with experiment. Responses of non-linear systems to pulses or other perturbations are analyzed, and mechanisms of oscillatory reactions are presented in detail. The concluding chapters give an introduction to bioinformatics and statistical methods for determining reaction mechanisms.

The Enzymes, Volume 1: Kinetics, Mechanism, Thermodynamics, Basic Properties

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The Enzymes, Volume 1: Kinetics, Mechanism, Thermodynamics, Basic Properties
Paul D.; Lardy, Henry & Myrback, Karl Boyer
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover
ASIN: B000K3G87Q

Regulatory Mechanisms of Striated Muscle Contraction (Advances in Experimental Medicine and Biology)

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Regulatory Mechanisms of Striated Muscle Contraction (Advances in Experimental Medicine and Biology)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 4431384510

Product Description

Troponin is a central subject in biochemical, biophysical, and physiological research. The discovery of this protein by Professor Setsuro Ebashi in 1965 initiated a new era in research into the molecular biology of the regulation of contraction in striated muscle. Troponin is one of the representative functional proteins in living organisms, and its structure and function have been studied extensively. Recently, the crystallographic structure of troponin ternary complex was determined successfully. Mutations in genes of cardiac isoforms of troponin have been shown to cause cardiomyopathies, and the pathogenic consequences of these genetic disorders are being investigated. In clinical medicine, troponin is now widely utilized as an excellent biochemical marker for myocardial infarction. This volume covers the entire spectrum of research on troponin and related muscle proteins, including pathophysiological and clinical aspects.

Reduced Kinetic Mechanisms for Applications in Combustion Systems (Lecture Notes in Physics)

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Reduced Kinetic Mechanisms for Applications in Combustion Systems (Lecture Notes in Physics)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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