Liquid Chromatography-Mass Spectrometry, Third Edition (Chromatographic Science)

Book Description

A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and applications. As the technology itself has matured into a reliable analytical method over the last 15 years, the most exciting developments occur in LC-MS augments research into new applications. This edition places a stronger emphasis than previous editions on the impact of LC-MS methods, dedicating two-thirds of the text to small-molecule and biomolecular applications such as proteomics, pharmaceutical drug discovery and development, biochemistry, clinical analysis, environmental studies, and natural products research. Supported by the most relevant literature available, each chapter examines how the strategies, technologies, and recent advances-from sample pretreatment to data processing-in LC-MS helped to shape these disciplines. Featuring new chapters and extensive revisions throughout the book, Liquid Chromatography-Mass Spectrometry, Third Edition continues to provide scientists with a definitive guide and reference to the most important principles, strategies, and experimental precedents for applying LC-MS to their research.

LC/MS Applications in Drug Development (Wiley - Interscience Series on Mass Spectrometry)

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LC/MS Applications in Drug Development (Wiley - Interscience Series on Mass Spectrometry)
Mike S. Lee
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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Similar Items:

LC/MS: A Practical User's Guide
Mass Spectrometry: Principles and Applications
Integrated Strategies for Drug Discovery Using Mass Spectrometry
GC/MS: A Practical User's Guide
Practical HPLC Method Development, 2nd Edition

ASIN: 0471405205

Book Description

Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:

Proteomics
Glycoprotein Mapping
Natural Products Dereplication
Lead Identification Screening
Open-Access LC/MS
In Vitro Drug Screening

Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

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Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:

-Proteomics
-Glycoprotein Mapping
-Natural Products Dereplication
-Lead Identification Screening
-Open-Access LC/MS
-In Vitro Drug Screening

Book Description

A practical guide to using and maintaining an LC/MS system

The combination of liquid chromatography (LC) and mass spectrometry (MS) has become the laboratory tool of choice for a broad range of industries that require the separation, analysis, and purification of mixtures of organic compounds.

LC/MS: A Practical User's Guide provides LC/MS users with an easy-to-use, hands-on reference that focuses on the practical applications of LC/MS and introduces the equipment and techniques needed to use LC/MS successfully. Following a thorough explanation of the basic components and operation of the LC/MS system, the author presents empirical methods for optimizing the techniques, maintaining the instrumentation, and choosing the appropriate MS or LC/MS analyzer for any given problem.

LC/MS covers everything users need to know about:

The latest equipment, including quadrupole, time-of-flight, and ion trap analyzers
Cutting-edge processes, such as preparing HPLC mobile phases and samples; handling and maintaining a wide variety of silica, zirconium, and polymeric separation columns; interpreting and quantifying mass spectral data; and using MS interfaces
Current and future applications in the pharmaceutical and agrochemical industries, biotechnology, clinical research, environmental studies, and forensics

An accompanying PowerPoint® slide-set on CD-ROM provides vital teaching tools for instructors and new equipment operators. Abundantly illustrated and easily accessible, the text is designed to help students and practitioners acquire optimum proficiency in this powerful and rapidly advancing analytical application.

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Presents technical data in an easily understood format, explains how to keep LC/MS systems up and running, and shows how to interpret and quantitate the mass spectral data using proven spectral databases, without devolving into a university-style course curriculum. Takes a purely practical approach to using and maintaining LC/MS systems Introduces the reader to quadrupole and ion trap analyzers, which make up the bulk of the equipment being sold for laboratory and analytical studies Presents technical data in an illustrated, easily understood format Explains how to keep systems up and running Shows how to interpret and quantitate mass spectral data using proven spectral databases

Customer Reviews:

a very good start point.......2006-04-24

A good introduction. But not for specialist. Some practical tips are useful.

Liquid Chromatography Mass Spectrometry: An Introduction (Analytical Techniques in the Sciences (AnTs) *)

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A very good book for beginners and students

Liquid Chromatography Mass Spectrometry: An Introduction (Analytical Techniques in the Sciences (AnTs) *)
Robert E. Ardrey
Manufacturer: Wiley
ProductGroup: Book
Binding: Paperback

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Similar Items:

LC/MS: A Practical User's Guide
Mass Spectrometry: Principles and Applications
A Beginner's Guide to Mass Spectral Interpretation
Electrospray Ionization Mass Spectrometry
Interpretation of Mass Spectra

ASIN: 0471498017

Book Description

First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique.

First book to concentrate on principles of LC-MS
Explains principles of mass spectrometry and chromatography before moving on to LC-MS
Describes instrumental aspects of LC-MS
Discusses current applications of LC-MS and shows benefits of using this technique in practice

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"This series of books provides coverage of all of the major analytical techniques and their application in the most important areas of physical, life and materials science. Each text is presented in an open learning/distance learning style, in which the learning objectives are clearly identified. The reader's understanding of the material is constantly evaluated by the use of self-assessment and discussion questions. The combination of gas chromatography with mass spectrometry (GC-MS) has been a routine analytical tool for many years, while the related hybrid technique of liquid chromatography-mass spectrometry (LC-MS) is a rather more recent development. However, with the advent of new interfacing technology, the benefits of this powerful hybrid analytical method are now currently being realised, as witnessed by the exponential growth in applications of this technique in both the chemical and life sciences. The topics covered in this text include the following: The basic principles of liquid chromatography and mass spectrometry. The limitations of the component techniques when used in isolation, and how a combination of the two allows these to be overcome. Descriptions of the various approaches, including thermospray, electrospray and atmospheric pressure chemical ionization, which are used to interface the two techniques, along with the advantages and disadvantages of each system. Illustrative examples of the applications of LC-MS, including the molecular weight and structure determinations of both biopolymers and low-molecular-compounds, along with the development of quantitative methods. Key features include: The provision of many discussion and self-assessment questions throughout the text, thus providing opportunities for testing the reader's understanding of the subject matter. Presented in the AnTS (open learning/distance learning) style, it is ideal for use as both a self-study guide and as the basis of a taught course.

Customer Reviews:

A very good book for beginners and students.......2005-07-19

This book is very fundamental. For someone with little knowledge about HPLC-MS, this is the right book for him/her. IF you want to learn LC/MS, start with this book.

A Global View of Lc/MS: How to Solve Your Most Challenging Analytical Problems

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A really useful resource
Good comprehensive look at instrumentation

A Global View of Lc/MS: How to Solve Your Most Challenging Analytical Problems
Ross Willoughby , Edward Sheehan , and Samuel Mitrovich
Manufacturer: Global View Pub
ProductGroup: Book
Binding: Paperback

Analytic | Chemistry | Science | Subjects | Books

General & Reference | Chemistry | Science | Subjects | Books

General | Science | Subjects | Books

LC/MS: A Practical User's Guide
Liquid Chromatography Mass Spectrometry: An Introduction (Analytical Techniques in the Sciences (AnTs) *)
Mass Spectrometry: Principles and Applications
Modern HPLC for Practicing Scientists

ASIN: 0966081307

Customer Reviews:

A really useful resource.......2004-01-24

I would highly recommend this book. It is clear, concise and helpful. One of the beat featurs is the "Additional Resources" section, which is full of references, links, etc. to other, equally helpful sources of information. The authors are up-to-date with all the new develpments, including APPI, which has only been introduced very recently.

If you only buy one LC/MS resource buy this one!

Good comprehensive look at instrumentation.......2000-01-29

Good book for a quick look at LC/MS or LC/MS/MS. If you are searching for application notes you may find better resources elsewhere.

Modern Methods for Lipid Analysis by Liquid Chromatography

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Modern Methods for Lipid Analysis by Liquid Chromatography
William Craig Brydwell
Manufacturer: AOCS Publishing
ProductGroup: Book
Binding: Hardcover

Analytic | Chemistry | Science | Subjects | Books

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ASIN: 1893997758

Book Description

Research into novel techniques for LC/MS continues to be a lively field, most notably regarding electrospray ionization and atmospheric pressure chemical ionization for analysis of lipids. This growing interest precipitated publication of this volume. A valuable reference and resource, Modern Methods is essential for those interested in moving into the field of lipid analysis using modern instrumentation. It describes previous work that helped establish the foundation of the discipline and demonstrates new data that is quickly defining a new level of "state-of-the-art." Described herein are the methods that will be applied to lipids into the next decade and hopefully beyond.

Advances in LC-MS Instrumentation, Volume 72 (Journal of Chromatography Library) (Journal of Chromatography Library)

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Advances in LC-MS Instrumentation, Volume 72 (Journal of Chromatography Library) (Journal of Chromatography Library)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

Analytic | Chemistry | Science | Subjects | Books

General & Reference | Chemistry | Science | Subjects | Books

General | Science | Subjects | Books

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ASIN: 0444527737

Book Description

The different LC-MS techniques available today were developed to suit specific analytical needs and the application range covered by each one is wide, but still limited. GC amenable compounds can be all analyzed with a single GC-MS system whereas HPLC applications call for specific LC-MS instrumental arrangements. ESI, APCI, APPI, and EI are ionization techniques that can be combined with different analyzers, in single or tandem configuration, to create the ultimate system for a certain application. Once approaching LC-MS for a specific need, the fast technical evolution and the variegated commercial offer can induce confusion in the potential user.
The role of this book is to enlighten the state-of-the-art of LC-MS evolution through a series of contributions written by the people that brought major, recent innovations in the field. Each chapter will take into consideration the novelties, the advantages and the possible applications covered by a particular technical solution. The book will also include new analytical methods that can provide benefits using the most recent innovations in LC-MS plus a certain number of key applications.

- Contains contributions from major innovators in the field
- Covers the latest developments in the field of LC-MS
- Gives a clear outline on the advantages of various techniques and their applications

Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry (Techniques and instrumentation in analytical chemistry)

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Analysis of Neuropeptides by Liquid Chromatography and Mass Spectrometry (Techniques and instrumentation in analytical chemistry)
Dominic M. Desiderio
Manufacturer: Elsevier
ProductGroup: Book
Binding: Hardcover

Biochemistry | Biological Sciences | Science | Subjects | Books

Chromatography | Chemistry | Science | Subjects | Books

Physiology | Basic Science | Medicine | Subjects | Books
ASIN: 0444424180

Applications of LC-MS in Environmental Chemistry (Journal of Chromatography Library)

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Applications of LC-MS in Environmental Chemistry (Journal of Chromatography Library)

Manufacturer: Elsevier Science
ProductGroup: Book
Binding: Hardcover

Analytic | Chemistry | Science | Subjects | Books

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ASIN: 0444820671

Book Description

Looking at the literature available, it is clear that there is a need for a book on LC-MS applications in environmental analysis. This book endeavours to answer the following questions: What interface to use to solve "my detection problem"? Can I obtain enough sensitivity for the confirmation of my compound in real-world environmental samples? Is there enough structural information?

The present book aims to provide a critical evaluation of LC-MS in environmental chemistry and it is structured in different areas. Apart from an introductory section with fundamental aspects, application areas using the most relevant interfacing systems (PB, TSP, ES) for the characterization of environmental compounds are included. In this sense, applications are discussed on the characterization of the most relevant compounds of environmental interest such as pesticides, detergents, dyes, polar metabolites, waste streams, organotin compounds and marine toxins with comparison between different interfacing systems. Finally, new methods and strategies in LC-MS, e.g. the use of capillary electrophoresis, MS together with on-line post-column systems in LC-MS are also shown.

By the nature of its content and written as it is by experienced practitioners, the book is intended to serve as a practical reference for analytical chemists who need to use LC-MS in environmental studies. Each chapter includes sufficient references to the literature to serve as a valuable starting point and also contains detailed investigations. The broad spectrum of the book and its application to environmental priority compounds makes it unique in many ways.

Applications of LC-MS in Toxicology
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Review of liquid chromatography-mass spectrometry (LC-MS) applications in toxicology

Applications of LC-MS in Toxicology

Manufacturer: Pharmaceutical Press
ProductGroup: Book
Binding: Hardcover

Pharmacy | Pharmacology | Medicine | Subjects | Books
Toxicology | Pharmacology | Medicine | Subjects | Books
General | Medicine | Subjects | Books
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Toxicology | Pharmacology | Medical | Professional & Technical | Subjects | Books
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ASIN: 0853696292

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Review of liquid chromatography-mass spectrometry (LC-MS) applications in toxicology.......2007-08-08

Applications of LC-MS in Toxicology is presented by Dr. Aldo Polettini and seventeen other authors. This timely monograph features a unique combination of advances in technology with practical challenges from experienced users. In addition to sufficient background information, topics ranging from current practices to associated applications are covered with reference to specific examples. The introductory and application chapters provide comparable summaries of the existing instrumentation; a format which allows the reader to choose a topic of interest. In return, they will obtain a synopsis of the basic principles pertaining to the selected subject. Additionally, descriptions of commonly used ionization and mass analysis techniques are given together with appropriate considerations and examples. There are twelve chapters with close to 900 references, which cover details ranging from theoretical concepts to operational implications regarding the use of conventional LC-MS instrumentation. The book is presented for researchers and practitioners but also provides an appropriate introduction for novice scientists.

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