Organic Synthesis on Solid Phase: Supports, Linkers, Reactions

Book Description

This is the number-one successful book on solid phase organic synthesis, now in its second, expanded edition. It offers the reader

· a comprehensive overview of supports, spacers, and linkers
· 15% more contents
· everything there is to know about reactions and their applications
· clear structure
· numerous experimental guidelines for use in practice

The ideal reference for newcomers and experts.

"... I have no doubts that this text will be the benchmark for future publications on the subject, and a very hard act to follow for authors planning books of their own on this red hot topic."

The Alchemist

Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series)

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Good book for peptide chemist.

Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0199637245

Book Description

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Customer Reviews:

Good book for peptide chemist........2004-11-04

This is a good book for peptide chemist. It has detailed protocol for almost all useful information about Fmoc solid phase peptide synthesis which is used in most of the peptide company, in our company, this book acts as a standard reference for our daily production. I strongly recommend you to buy one if you are or you want to be a peptide chemist.

Methods in Enzymology, Volume 289: Solid-Phase Peptide Synthesis (Methods in Enzymology)

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Methods in Enzymology, Volume 289: Solid-Phase Peptide Synthesis (Methods in Enzymology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0121821900

Book Description

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences.

Key Features
* Solid-phase peptide synthesis
* Applications of peptides for structural and biological studies
* Characterization of synthetic peptides

Average customer rating:

It is very good

Solid-Phase Organic Synthesis
Kevin Burgess
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471318256

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Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field.

Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:

Syntheses of guanidines
Palladium-catalyzed C-C bond forming reactions
S_nAr reactions for the formation of heterocycles
Sequence-specific arylalkyne oligomers
Resin-supported capture agents and other reagents
Synthesis on pins
Monitoring of supported reactions using IR
Solid-phase syntheses of natural product derivatives

Of related interest: Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application, Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

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Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include:
* Syntheses of guanidines
* Palladium-catalyzed C-C bond forming reactions
* S_nAr reactions for the formation of heterocycles
* Sequence-specific arylalkyne oligomers
* Resin-supported capture agents and other reagents
* Synthesis on pins
* Monitoring of supported reactions using IR
* Solid-phase syntheses of natural product derivatives
Of related interest . Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

Customer Reviews:

It is very good.......2000-10-12

I am interesting in the book. Now, I am studying polymerization organic films by vapor despition under UV excition.I want to know the mechanism of solid-phase reactions and utilize the reactions to make polymer films.

Handbook of Reagents for Organic Synthesis , Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis (Hdbk of Reagents for Organic Synthesis)

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Handbook of Reagents for Organic Synthesis , Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis (Hdbk of Reagents for Organic Synthesis)

Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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Handbook of Reagents for Organic Synthesis , Reagents for Glycoside, Nucleotide, and Peptide Synthesis (Hdbk of Reagents for Organic Synthesis)

ASIN: 047086298X

Book Description

Since its discovery in 1963 by R. B. Merrifield, solid-phase synthesis, or polymer-supported synthesis, has become an essential technique with its wide use in the synthesis of peptides and other oligomers. Solid-Phase Reactions provides extensive and comprehensive information on this form of synthesis in a format ideal for those working in the laboratory.

Book Description

A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies

The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies:

Surveys the most recent developments in SPS and combinatorial chemistry
Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library
Discusses choice of format, size, and the rationale behind the design of each synthetic step
Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries
Employs a large number of examples to illustrate important concepts
Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis
Describes the quality control and activity screening of combinatorial libraries for various applications
Features a detailed bibliography of more than 1,700 relevant sources

Customer Reviews:

A good book for beginner.......2003-12-25

This book gives a clear concept of solid-phase synthesis.
Good for beginner in this area. It also gives a lot of information including examples in some interesting application in the real synthesis.

Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

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Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries

Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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Book Description

Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.
With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and "on-resin" analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as:

Specific oligosaccharide structures used in signal transduction processes
Preparation and screening of glycopeptide libraries
Solid-phase carbohydrate synthesis

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Specific oligosaccharide structures used in signal transduction processes
Preparation and screening of glycopeptide libraries
Solid-phase carbohydrate synthesis

Optimization of Solid-Phase Combinatorial Synthesis

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Optimization of Solid-Phase Combinatorial Synthesis

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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"Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies."

Bruce Merrifield: Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis (Profiles, Pathways, and Dreams)

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Bruce Merrifield: Life During a Golden Age of Peptide Chemistry: The Concept and Development of Solid-Phase Peptide Synthesis (Profiles, Pathways, and Dreams)
Bruce Merrifield
Manufacturer: An American Chemical Society Publication
ProductGroup: Book
Binding: Hardcover

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ASIN: 0841218420

Book Description

Bruce Merrifield, eminent American scientist, 1984 Nobel Prize winner and professor at The Rockefeller University, is noted for his single-handed development of solid phase peptide synthesis. The progress of biochemistry and related fields is closely correlated with the availability of pure peptides, and in this volume, Merrifield describes nearly 40 years of progress. The warmth and kindness of this sincere gentleman is described by his personal experiences. Many photographs depict both the professional as well as the personal side of Bruce Merrifield.

Innovation & Perspectives in Solid Phase Synthesis 1992: Peptides, Poly

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Innovation & Perspectives in Solid Phase Synthesis 1992: Peptides, Poly

Manufacturer: Intercept
ProductGroup: Book
Binding: Hardcover

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