Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in Medicinal Chemistry)

Book Description

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability.

Book Description

AN AUTHORITATIIVE, UP-TO-DATE INTRODUCTION TO PHYSICAL ACOUSTICS

Easy to read and understand, Fundamentals of Physical Acoustics fills a long-standing need for an acoustics text that challenges but does not overpower graduate students in engineering and physics. Mathematical results and physical explanations go hand in hand, and a unique feature of the book is the balance it strikes between time-domain and frequency-domain presentations.

Fundamentals of Physical Acoustics is intended for a two-semester, first-year graduate course, but is also suitable for advanced undergraduates. Emphasis on plane waves in the first part of the book keeps the mathematics simple yet accommodates a broad range of topics: propagation, reflection and transmission, normal modes and simple waveguides for rectilinear geometries, horns, inhomogeneous media, and sound absorption and dispersion.

The second part of the book is devoted to a more rigorous development of the wave equation, spherical and cylindrical waves (including the more advanced mathematics required), advanced waveguides, baffled piston radiation, diffraction (treated in the time domain), and arrays. Applications and examples are drawn from:

Atmospheric acoustics
Noise control
Underwater acoustics
Engineering acoustics
Acoustical measurements

Supplemented with more than 300 graphs and figures as well as copious end-of-chapter problems, Fundamentals of Physical Acoustics is also an excellent professional reference for engineers and scientists.

Customer Reviews:

Not finished yet........2007-08-23

Having only got through the first few pages I can say that it is well written and written in a style that explains everything clearly.
No complaints at all.

A fairly practical book for a complex topic.......2006-12-07

I knew I liked this book when I read section C of the introduction:

"How is the wave equation derived? Three common physical systems that carry waves - the electrical transmission line, the flexible string, and the compressible fluid - are considered in this section."

I needed a practical book to help me when I somehow volunteered myself to perform some acoustic experiments at work. They kind of said "Hey, you're a physicist. Can you do this?" And then I said "Uh... sure." I read through what I could find in Halliday and Resnick, a book I like for its simplicity. But then I needed something more complicated, so I bought Morse and Ingard, which was way too much. Then I found this book.

And its a good thing I did. The book uses the wave equation to solve each of these problems, and if you pay attention, you can assemble a nice, general approach to solving problems of this nature, and you'll have a list of analogous variables when you're done. The whole book is written like this. It's not an ASM Handbook by any means, but it is more practical than Morse and Ingard, has more drawings and diagrams, and I was surprised to find one of the cleanest, simplest descriptions of Bessel functions I've seen yet. The book addresses the complex problems without doing endless integrals, and it whenever possible it works through the problem and doesn't rely on phrases like "the reduction of step X to step Y is left as an exercise for the student" in its derivations. I appreciate this - it makes the book more friendly as a reference text.

Also, when I was a graduate student I never paid attention to literature references in text books because I (naively) considered them to be outdated. But a literature search is one of the best tools I have available to me in the working world - if you have access to a literature database, you will find the literature references at the end of some chapters to be very useful.

Consider it a useful reference text, and probably a practical textbook as well.

Best intro to acoustics for engineers especially.......2006-12-05

This book is geared towards graduate and upper undergraduate students in physics and engineering. The first nine chapters of the book are restricted to plane waves. Thus the first half of the book introduces the reader to a wide variety of acoustical concepts such as propagation, reflection, transmission, refraction, normal modes, horn theory, absorption, and dispersion. All the while, the first half of the book keeps mathematical complexity to a minimum. The second half of the book relies more on advanced mathematics and is a survey of advanced topics dependent on the reader understanding the first nine chapters of the book. For the second half of the book, it will be helpful if you know calculus as well as differential equations. Each chapter has plenty of exercises so you can practice what you've learned.

Although the coverage is not as broad as Kinser's book on acoustics, this book does a much better job of explaining the foundations of acoustics including the math, which can get quite involved. I really love how Blackstock makes use of figures when explaining concepts and adding in the mathematics to the figure explanation in a way that you will remember the material. My advice is that if you are looking for a good introduction to acoustics, this is the book to read. Once you conquer this and you want something broader that goes into such topics as nonlinear acoustics and underwater acoustics, you probably want to look at Kinsler's "Fundamentals of Acoustics". The following is the table of contents:

1. Introduction
2. Detailed Development of the Acoustical Wave Equation.
3. Reflection and Transmission of Normally Incident Plane Waves of Arbitrary Waveform.
4. Normal Incidence Continued: Steady-State Analysis.
5. Transmission Phenomena: Oblique Incidence.
6. Normal Modes in Cartesian Coordinates: Strings, Membranes, Rooms, and Rectangular Waveguides.
7. Horns.
8. Propagation in Stratified Media.
9. Propagation in Dissipative Fluids: Absorption and Dispersion.
10. Spherical Waves.
11. Cylindrical Waves.
12. Waveguides.
13. Radiation from a Baffled Piston.
14. Diffraction.
15. Arrays.

Wonderful Book.......2005-04-27

I think this is one of the best books on Physical Acoustics.
I would recommend this book to anyone starting to learn acoustics. This statement does not mean that advanced students should not go for this book, as it also covers advanced materials.

My opinion about the book can resumed as follows:

- Clear and concise
- Very good presentation
- Relatively easy to follow
- Very good for self-studying (plan to study the book is recommended by the author)
- There is a derivation (or instructions on how to get) to almost every equation in the book.
- Not too theoretical. Many practical interpretations of the mathematical results are given. (percentage of mathematics well balanced)
- The author makes apparently difficult material simple!

From this book one can jump to more advanced texts (Theoretical Acoustics by Morse and Ingard and Acoustics - An Introduction to its Physical Principles and Applications by Pierce).

Fundamentals of Acoustics by Kinsler et al is also a good book for a beginner, but I think this one is much better.

Moral of the story, I really like this book!

Ps: This is an opinion of a beginner on Physical Acoustics more interested in air applications, that never had lessons about this topic. I don't know if my opinion will change as my knowledge on this field increases:) I doubt it!

Excellent text and reference.......2000-06-13

I find this book clear and concise. This is the reference I use most often at work when I want insight into the physics behind a noise or vibration problem.

Average customer rating:

Especially commended to students of engineering

Radiative Heat Transfer
Michael F. Modest
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

Aeronautics & Astronautics | Astronomy | Science | Subjects | Books

General | Science | Subjects | Books

General | Engineering | Professional & Technical | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Amazon Upgrade | Amazon Upgrade | Stores | Books

Engineering | Amazon Upgrade | Stores | Books

Professional & Technical | Amazon Upgrade | Stores | Books

Science | Amazon Upgrade | Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books

Science | Qualifying Textbooks - Fall 2007 | Stores | Books
Similar Items:

ASIN: 0125031637

Book Description

Every chapter of Radiative Heat Transfer offers uncluttered nomenclature, numerous worked examples, and a large number of problems - many based on "real world" situations, making it ideal for classroom use as well as for self-study. The book's 22 chapters cover the four major areas in the field: surface properties; surface transport; properties of participating media; and transfer through participating media. Within each chapter, all analytical methods are developed in substantial detail, and a number of examples show how the developed relations may be applied to practical problems.

· Extensive solution manual for adopting instructors
· Most complete text in the field of radiative heat transfer
· Many worked examples and end-of-chapter problems
· Large number of computer codes (in Fortran and C++), ranging from basic problem solving aids to sophisticated research tools
· Covers experimental methods

Customer Reviews:

Especially commended to students of engineering.......2003-05-22

Now in an updated and expanded second edition, Radiative Heat Transfer by Michael F. Modest is a college-level mechanical and chemical engineering textbook, specifically written and intended for advanced students already familiar with basic calculus. Individual chapters address radiative exchange between a variety of surfaces; equations, functions, and methodologies; the influence of conduction and convention, and much, much more. An advanced resource and an excellent text or supplement to engineering education, Radiative Heat Transfer is especially commended to students of Mechanical Engineering and Chemical Engineering.

Absorption and Scattering of Light by Small Particles (Wiley Science Paperback Series)

Average customer rating:

Excellent text for Absorption and Scattering!
Excellent
Very well written exposition, 1st-rate content.
Excellent resource for motivated student or expert
One of the best books on light scattering.

Absorption and Scattering of Light by Small Particles (Wiley Science Paperback Series)
Craig F. Bohren , and Donald R Huffman
Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Paperback

General | Science | Subjects | Books

Acoustics & Sound | Physics | Science | Subjects | Books

General | Physics | Science | Subjects | Books

Molecular Physics | Physics | Science | Subjects | Books

Optics | Physics | Science | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Deals | Blowout Books | Stores | Books

Science | Blowout Books | Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books

Science | Qualifying Textbooks - Fall 2007 | Stores | Books
Similar Items:

ASIN: 0471293407

Book Description

Absorption and Scattering of Light by Small Particles
Treating absorption and scattering in equal measure, this self-contained, interdisciplinary study examines and illustrates how small particles absorb and scatter light. The authors emphasize that any discussion of the optical behavior of small particles is inseparable from a full understanding of the optical behavior of the parent material-bulk matter. To divorce one concept from the other is to render any study on scattering theory seriously incomplete.
Special features and important topics covered in this book include:
* Classical theories of optical properties based on idealized models
* Measurements for three representative materials: magnesium oxide, aluminum, and water
* An extensive discussion of electromagnetic theory
* Numerous exact and approximate solutions to various scattering problems
* Examples and applications from physics, astrophysics, atmospheric physics, and biophysics
* Some 500 references emphasizing work done since Kerker's 1969 work on scattering theory
* Computer programs for calculating scattering by spheres, coated spheres, and infinite cylinders

Customer Reviews:

Excellent text for Absorption and Scattering!.......2005-06-06

Bohren and Huffman present a coherent and comprehensive description of absorption and scattering by small particles. The text is written in a very amusing style, where ideas are presented in a conversation like manner, as if the authors are directly addressing the reader, providing jokes and examples to illustrate their point. This text builds upon the description provided by Hulst in classic text, and provides a deal of useful information particularly related to absorption (not covered by the text of Hulst)!

The first eight chapters illustrate the basic theory of scattering and absorption, introducing expression and physics relevant to spheres, spheroids and a whole array of particles. This section is quite similar in spirit to the text by Hulst, requires a background in electrodynamics (to make it most useful) . In part II and part III, the authors discuss the optical constants of bulk matter and small particles respectively, citing examples of metallic as well as semiconducting particles. This book fills the need for a textbook for studying extinction coefficients of all kinds of particles, and is useful for physicists, chemists, meteorologists, material scientists, etc. Nonlinear optics is not covered, as also the effect of multi-particle scattering (and thankfully so)!

The book is very useful for people studying absorption (and scattering) of nanoparticles. It contains a good description of basic physics of plasmon resonance, extremely relevant to the research of people studying metallic particles. Bohren has written some really amusing as well as insightful "science" books on experiments and observations of physical phenomenon in daily life (and atmospheric sciences). This book is similar, with additional detail in terms of mathematical equations:)! Extremely useful for researchers and scientists even remotely associated with studies of absorption and scattering by particles! In terms of usefulness, this book is much better than the text by Kerker on similar topic!

Excellent.......2003-02-15

Very good choice of topics. Clear presentation. Caters to a wide variety of audiences.

I'd give it a 5 if it included a chapter devoted practical aspects of experimental light scattering measurements, techniques, and instrumentation.

Very well written exposition, 1st-rate content........2000-11-09

The authors' lively and `user-friendly' style of presentation help bring material of an advanced nature within the reach of a larger number of readers than most books that deal with the subject at this level. I highly recommend this classic reference.

Excellent resource for motivated student or expert.......1999-06-29

I have found this to be a very useful reference for calculations of light-scattering properties of particles of various sizes and shapes. Discussions of subjects ranging from geometrical optics to Mie theory appear clear and complete. The book also includes computer algorithms for computing scattering properties of homogeneous spheres, coated spheres and cylinders.

One of the best books on light scattering........1998-09-07

This book must be on the table of every researcher in light scattering field.

Average customer rating:

Methods for Skin Absorption
Barbara W. Kemppainen , and William G. Reifenrath
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

Toxicology | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Dermatology | Specialties | Medicine | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books
ASIN: 0849346517

Book Description

This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.

Percutaneous Penetration Enhancers, Second Edition

Average customer rating:

Good book

Percutaneous Penetration Enhancers, Second Edition

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Dermatology | Specialties | Medicine | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Medicine | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books

Science | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 0849321522

Book Description

Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.

Customer Reviews:

Good book.......2000-11-28

This is very valuable bood for Pharmaceutical researcher focused in transdermal project.

In Vitro Percutaneous Absorption: Principles, Fundamentals, and Applications

Average customer rating:

Useful for experimental design...and more

In Vitro Percutaneous Absorption: Principles, Fundamentals, and Applications
Robert L. Bronaugh , and Howard I. Maibach
Manufacturer: Informa Healthcare
ProductGroup: Book
Binding: Hardcover

General | Science | Subjects | Books

Physiology | Basic Science | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Dermatology | Specialties | Medicine | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 0849347483

Book Description

This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

Customer Reviews:

Useful for experimental design...and more.......2000-01-05

'In Vitro Percutaneous Absorption' is a collection of papers by various researchers. It provides an insight into the skin absorption research community.

For experimental researchers, 'In Vitro PC' is useful for design and preparation of experiments. It is also useful in revealing common sources of experimental error.

For those not performing in vitro experiments, there are two chapters that are useful for understanding the mechanisms of percutaneous absorption, and how enhansors such as DMSO and azones work (both chapters are first rate). The chapter on the LPL Theory of skin penetration offers a concise, understandable concept of percutaneous absorption. The chapter on penetration enhansors details classes of enhansor chemicals and their mechnism of action. It also addresses synergy between enhansors, and efficy.

Book Description

Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts discuss the bioequivalence of dermatological and transdermal dosage forms. They explore the biochemistry and treatment of skin diseases, the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation.

Thermal Radiation Heat Transfer (McGraw-Hill Series in Transportation)

Average customer rating:

Review of Siegel's Radiation Heat Transfer
The Definative Book on Thermal Radiative Heat Transfer
Great textbook, great reference book
Good, but misplaces the heat retention theory.

Thermal Radiation Heat Transfer (McGraw-Hill Series in Transportation)
Robert Siegel , and John R. Howell
Manufacturer: Taylor & Francis Group
ProductGroup: Book
Binding: Library Binding

General | Transportation | Nonfiction | Subjects | Books

Reference | Engineering | Professional & Technical | Subjects | Books

General | Science | Subjects | Books

General | Physics | Science | Subjects | Books

Applied | Physics | Science | Subjects | Books

Engineering | Reference | Science | Subjects | Books

Look Inside Nonfiction Books | Trip | Specialty Stores | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books

Nonfiction | Qualifying Textbooks - Fall 2007 | Stores | Books

Professional | Qualifying Textbooks - Fall 2007 | Stores | Books

Science | Qualifying Textbooks - Fall 2007 | Stores | Books
Similar Items:

ASIN: 0891162712

Book Description

This extensively revised 4th edition provides an up-to-date, comprehensive single source of information on the important subjects in engineering radiative heat transfer. It presents the subject in a progressive manner that is excellent for classroom use or self-study, and also provides an annotated reference to literature and research in the field. The foundations and methods for treating radiative heat transfer are developed in detail, and the methods are demonstrated and clarified by solving example problems. The examples are especially helpful for self-study. The treatment of spectral band properties of gases has been made current and the methods are described in detail and illustrated with examples. The combination of radiation with conduction and/or convection has been given more emphasis nad has been merged with results for radiation alone that serve as a limiting case; this increases practicality for energy transfer in translucent solids and fluids. A comprehensive catalog of configuration factors on the CD that is included with each book provides over 290 factors in algebraic or graphical form. Homework problems with answers are given in each chapter, and a detailed and carefully worked solution manual is available for instructors.

Customer Reviews:

Review of Siegel's Radiation Heat Transfer.......2006-03-22

Overall, good text for radiation heat transfer. Certain cases in radiation problems where the solution will involve some numerical technique are not emphasized enough in the example problems.

The Definative Book on Thermal Radiative Heat Transfer.......2003-01-30

Thermal Radiation Heat Transfer by Robert Siegel and John Howell is probably the ,most widely used text for graduate students and is the book I have probably used more than any other in my professional engineering career. Originally published in the 1960's as a NASA Special Publication (SP-164), this book has been significantly updated three times since its initial published in 1972. In this latest version of the book, the authors cover the standard radiation heat transfer topics, such as the Stefan-Boltzmann relation, blackbody radiation, the various forms of optical surfaces properties (emissivity, transmissivity, absorptivity, diffuse, specular and much more), and an enclosure analysis. Topics, which are often overlooked in other textbooks, such as gas radiation, scattering, multi-mode heat, the Maxwell relationships, are given a thorough examination in this book. Furthermore, this latest edition of the book includes a CD-ROM contains a catalog of 290 configuration factors in algebraic or graphical form, plus homework problems. Finally, if you are looking for an excellent textbook which covers almost aspects of radiation heat, this book is a must, especially for those people planning of a career in which is involved with heat transfer.

Great textbook, great reference book.......2002-03-07

This is fourth edition of excellent monograph that comprises all theoretical and computational problems of radiative heat transfer. In comparison with the previous edition, the book of R. Siegel and J. R. Howell is updated by the state-of-the-art material concerning the analysis of radiative heat transfer in absorbing, emitting, and scattering media, in semitransparent bodies, modern applications of Monte Carlo method etc. The book may serve a great textbook for university students, as well as a great reference book for all experts in radiation heat transfer. Accompanying CD-ROM with the catalog of radiation configuration factors (bibliographic rarity, up to a recent time available only on John Howell's web site) will be a reliable tool to everyone who deals with computation of radiation transfer within system of diffuse surfaces. I beleive this is a best book in its area (you may compare with the books of Sparrow & Cess or Modest)

Good, but misplaces the heat retention theory........1998-12-06

This book is scientifically applicable, but lacks certain validity concerning heat retention, and other various forms heat transfer. I would reccomend this book to anybody who is interested in thermodynamics, but a profound interest it must be, because for most, it may seem a little dry. I give it 2 stars, but I would have given it higher if it's theories had been more precise. Mr. Siegel obviously knows his thermodynamics , though, and it is a rather intriguing book, once you get into the more exciting thermal theories. A good book, all in all, and I hope Mr.Siegel authors other books that I may be able to obtain.

Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition (Drugs and the Pharmaceutical Sciences)

Average customer rating:

Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fourth Edition (Drugs and the Pharmaceutical Sciences)

Manufacturer: Informa Healthcare
ProductGroup: Book
Binding: Hardcover

General | Pharmacology | Medicine | Subjects | Books

Toxicology | Pharmacology | Medicine | Subjects | Books

General | Medicine | Subjects | Books

Dermatology | Specialties | Medicine | Subjects | Books

Look Inside Science Books | Trip | Specialty Stores | Books

All Titles | Qualifying Textbooks - Fall 2007 | Stores | Books
ASIN: 1574448692

Book Description

Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, the fourth edition of Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methodology includes new chapters on topics currently impacting the field including chemical mixtures, in-vivo and in-vitro absorption correlations, transcutaneous immunization, and hair follicle penetration. It emphasizes drug delivery techniques such as the use of microneedles, nanosomes, liposomes, microemulsions, phonophoresis, and the enhancement of oligonucleotide drug penetration. The Journal of Applied Cosmetology said the first edition was "indispensable."

Books:

Books Index

Books Home

Recommended Books