Fmoc Solid Phase Peptide Synthesis: A Practical Approach (Practical Approach Series)

Book Description

In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

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Good book for peptide chemist........2004-11-04

This is a good book for peptide chemist. It has detailed protocol for almost all useful information about Fmoc solid phase peptide synthesis which is used in most of the peptide company, in our company, this book acts as a standard reference for our daily production. I strongly recommend you to buy one if you are or you want to be a peptide chemist.

Methods in Enzymology, Volume 289: Solid-Phase Peptide Synthesis (Methods in Enzymology)

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Methods in Enzymology, Volume 289: Solid-Phase Peptide Synthesis (Methods in Enzymology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0121821900

Book Description

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences.

Key Features
* Solid-phase peptide synthesis
* Applications of peptides for structural and biological studies
* Characterization of synthetic peptides

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Chemistry of Peptide Synthesis
N. Leo Benoiton
Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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ASIN: 1574444549

Book Description

Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author's role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of the field. The author first outlines the fundamentals of peptide synthesis, focusing on the intermediates in aminolysis reactions. Gradually the text builds into discussions of the applicability of coupling reactions, stereomutation, methods of deprotection, solid-phase synthesis, side-chain protection and side reactions, and amplification on coupling methods. The book clarifies the differences between oxazolones from amino-acid derivatives and segments and the implications of their formation on the chiral integrity of products. The author offers a critical analysis of the mechanisms of coupling reactions and the desirability of preactivation. The text explains hindrance and the nucleophilicity of tertiary amines and rationalizes their use. The book also explores mechanisms of acidolysis and the dual role of nucleophiles as reactants and scavengers. Chemistry of Peptide Synthesis supplies a broad, yet straightforward approach that appeals to those with limited knowledge of organic chemistry or chemists from other fields as well as in-depth coverage that can be appreciated by experienced peptidologists.

Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, 7)

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A book for student to understand basic idea about peptide synthesis.

Amino Acid and Peptide Synthesis (Oxford Chemistry Primers, 7)
John Jones
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0199257388

Book Description

The study of amino acids and peptides is becoming increasingly important to chemists becuase of the growing overlap of mainstream organic chemistry with bioorganic chemistry and biochemistry. This introductory text begins with a brief survey of the role and diversity of amino acids, peptides, and proteins in nature, and goes on to describe and explain the principal methods of chemical synthesis. With its emphasis on chemical principles and strategies rather than detailed technical matters, the book will be essential reading for all students of chemistry and biochemistry with an interest in this important field. This second edition contains extensive additions and adjustments, to present a completely up-to-date account of the chemical essentials of mainstream peptide synthesis.

Customer Reviews:

A book for student to understand basic idea about peptide synthesis........2007-01-05

This is a good for a text book. It can help you to understand basic chemistry of peptide synthesis. It doesn't tell you the detail procedure about how to synthesis peptide. You have to buy some books such as "Fmoc-peptide synthesis" if you are really working on peptide synthesis and need step-by-step procedures for synthesizing different type of peptides.

Handbook of Reagents for Organic Synthesis , Reagents for Glycoside, Nucleotide, and Peptide Synthesis (Hdbk of Reagents for Organic Synthesis)

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Handbook of Reagents for Organic Synthesis , Reagents for Glycoside, Nucleotide, and Peptide Synthesis (Hdbk of Reagents for Organic Synthesis)

Manufacturer: Wiley
ProductGroup: Book
Binding: Hardcover

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ASIN: 047002304X

Book Description

This handbook collects together short, informative articles on approximately 250 of the most widely used reagents in the field, into a single volume. Each of the articles, drawn from the e-EROS database, contains a summary of the most pertinent reactions for every reagent, with references to the original literature. This handbook will have a broad appeal and should find a home in every organic chemistry laboratory and library.

Compiles all the essential reagents for syntheses on and with biomolecules
Gives key information on protection, bond formation and deprotection
An essential resource for all synthetic chemists working in drug development and medicinal chemistry
Makes use of the leading reagent database e-EROS

Peptidomimetics Protocols (Methods in Molecular Medicine)

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Peptidomimetics Protocols (Methods in Molecular Medicine)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Book Description

A state-of-the-art collection of detailed synthetic procedures that lead to a variety of scaffolds, turn mimetics, peptide-bound replacements, and enzyme inhibitors. Topics range from unusual syntheses of amino acids to the use of a variety of linear and heterocyclic scaffolds in place of the peptide backbone. Important chemical procedures and methods include the transient protection of charged peptides as neutral prodrugs for improved blood-brain penetration and the replacement of peptide bonds with heterocyclic rings, olefins and fluoroolefins, and ketomethylenes. Synthetic protocols towards the transition-state mimics and reactive "warheads," applicable in enzyme inhibitors, are also disclosed.

Peptide Arrays on Membrane Supports: Synthesis and Applications (Springer Lab Manuals)

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Peptide Arrays on Membrane Supports: Synthesis and Applications (Springer Lab Manuals)

Manufacturer: Springer
ProductGroup: Book
Binding: Spiral-bound

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ASIN: 3540425322

Book Description

Proteins interacting with diverse ligands - proteins, peptides or DNA - are the basic principles underlying many biological processes, such as antigen-antibody binding, signal transduction or receptor binding.
The technique of oligopeptide synthesis on a cellulose membrane and the subsequent binding assays allow the investigation of protein interactions. A particular advantage of these peptide arrays (SPOT - technology) is the high number of oligopeptide probes that can be tested in parallel. Detailed protocols for peptide synthesis, and the analysis of protein-protein, protein-DNA interactions as well as epitope mapping are presented in this manual. It is ideally suited not only for basic research laboratories but also for diagnostic and therapeutic applications since many diseases are related to dysfunctions in protein recognition and binding.

Synthetic Peptides: A User's Guide (Uwbc Biotechnical Resource Series)

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Synthetic Peptides: A User's Guide (Uwbc Biotechnical Resource Series)

Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0716770091

Book Description

Contemporary solid-phase peptide synthesis is a streamlined, automated technology and its products are more readily available to a larger group of researchers than ever before. But because many researchers rely on contract services to obtain their peptides, they are often not familiar with
the "tricks of the trade" in artificial peptide design, manufacturing, and handling. This practical guide to the new peptide synthesis helps you to use artificial peptides more effectively, devise efficient experiments and avoid common pitfalls. The appendix lists sources offering custom peptide
synthesis or other analytical services. Synthetic Peptides is the second volume in the UWBC Biotechnical Resource Series with Dr. Richard R. Burgess, Director of the University of Wisconsin Biotechnology Center, as Series Editor. The series is dedicated to providing practical guidance to
researchers exploring new technologies and services.

Peptide Synthesis and Applications (Methods in Molecular Biology)

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Peptide Synthesis and Applications (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588293173

Book Description

Hands-on experts describe in step-by-step detail the key methodologies of contemporary peptide synthesis and illustrate their numerous applications. The techniques presented include protocols for chemical ligation, the synthesis of cyclic and phosphotyrosine-containing peptides, lipoamino acid- and sugar-conjugated peptides, and peptide purification and analyses. Additional chapters detail methodologies and instrumentation for high-throughput peptide synthesis, many different applications of peptides as novel research tools and biological probes, and the design and application of fluorescent substrate-based peptides that can be used to determine the selectivity and activity of peptidases. A practical guide to the identification of proteins using mass spectrometric analyses of peptide mixtures is also included.

Amino Acids, Peptides & Proteins (Specialist Periodical Reports)

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Amino Acids, Peptides & Proteins (Specialist Periodical Reports)
Royal Society of Chemistry
Manufacturer: Not Avail
ProductGroup: Book
Binding: Hardcover

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