Bacteriophages: Biology and Applications

Book Description

Since the introduction of antibiotics, Western medicine has paid little attention to bacteriophages for dealing with bacterial infection. In response to the emergence of pathogenic bacteria that cannot be treated with current antibiotics, many researchers are revisiting the use of bacteriophages, or phages, to fight multidrug-resistant bacteria, as they can effectively kill bacteria resistant to all currently available antibiotics, and are more specific, more adaptive, and less expensive to produce than antibiotics. Bacteriophages: Biology and Applications provides unparalleled, comprehensive information on bacteriophages and their applications, such as phage therapy. It explores the history, biology, ecology, genomics, and applications of phages, and provides an overview of phage literature from research techniques and basic molecular biology to applications in agriculture, human therapy, and biotechnology. Chapters include the role of phages in bacterial evolution, the molecular mechanisms of phages' interactions with bacteria, the control of bacteriophages in industrial fermentations, and bacteriophage therapy in animals and humans. A detailed appendix includes the techniques, media, and methodology involved in isolating and working with phages. Filled with many helpful photographs, line drawings, and electron micrographs of phages, this is an ideal reference for scientists and researchers from a wide variety of disciplines.

Immunochemical Protocols (Methods in Molecular Biology)

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Immunochemical Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1588292746

Book Description

This new edition of a much praised classic includes both basic method for producing and using antibodies and advanced techniques required by today's state-of-the art investigators. The basic sections of the book stress the first principles of antibody production and guide the reader through the processes and pitfalls of immunochemistry. The advanced sections focus on specific applications and cover the immunochemical techniques now used in laboratories. New material includes techniques for making new monoclonal cell lines, for producing good quality monoclonal antibodies, immunocapture PCR, immunoaffinity purification, and immunoelectron microscopy in plant virus diagnosis.

Making and Using Antibodies: A Practical Handbook

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ollection of Articles Representing the State of the Art

Making and Using Antibodies: A Practical Handbook

Manufacturer: CRC
ProductGroup: Book
Binding: Plastic Comb

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ASIN: 0849335280

Book Description

Antibodies are an indispensable tool in the study of biology and medicine. Making and Using Antibodies: A Practical Handbook presents techniques in a single, comprehensive source for the production and use of antibodies. It enables researchers to immediately access lab-tested, proven protocols. Written and edited by an elite team of scientists, who have developed and refined many of the methods, this book covers- · Commercially available adjuvants designed for the production of antisera in the research setting · Methods for the production, purification, and characterization of antibodies · Practical guidance to researchers needing to modify antibodies · Basic techniques including enzyme-linked immunosorbent assay (ELISA), Western blotting, immunohistochemistry, and flow cytometry · Methods for applying immunolabeling to the realm of electron microscopy (EM) · New antibody sources and new ways to use antobodies Making and Using Antibodies: A Practical Handbook also offers invaluable insight into future directions, challenges, and opportunities both in research and industrial applications.

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ollection of Articles Representing the State of the Art.......2007-03-14

This is a book that reflects the state of the art in making and using antibodies. It is written by a team of scientists from all over the United States who have developed and refined many of the methods discussed. It further offers invaluable insight into future directions, challenges and opportunities in research and industrial applications.

Features:

. Describes basic laboratory techniques in detail, accompanied by practical examples.
. Contains an outstanding selection of references for follow-up work.
. Includes cross-referencing of methods allowing for easy access to information.
. Illustrates the importance of ethical considerations and safety in laboratory research.
. Features introductory material for each chapter, providing a better understanding of the meghods and applications.
. Examines potential problems and notes trouble shooting tips.

Peptide Antibiotics: Discovery: Modes of Action, and Applications

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Peptide Antibiotics: Discovery: Modes of Action, and Applications

Manufacturer: CRC
ProductGroup: Book
Binding: Hardcover

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Antimicrobial Peptides and Human Disease (Current Topics in Microbiology and Immunology)

ASIN: 082470245X

Book Description

This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response. Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including: · the distribution and classification of diverse antimicrobial peptides throughout nature · the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins · the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin · the genetic basis determining the production of bacterial peptide antibiotics · the potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agents · the use of nisin as a commercial food preservative With contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.

Immunobiology of Carbohydrates (Molecular Biology Intelligence Unit)

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Immunobiology of Carbohydrates (Molecular Biology Intelligence Unit)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 0306478447

Book Description

This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens.
The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are written by investigators from various disciplines (chemistry, medicine, biochemistry, glycobiology and immunology), creating a fine balance in the point of views presented in the book. It explores the challenges and rewards of understanding the importance of carbohydrates and glycoconjugates in health and disease, applying new knowledge from carbohydrate immunology in improving or developing novel sugar-based therapeutics, and vaccines and medicines.
This book is most suitable for glycobiologists and immunologists, but many researchers whose interests, background and expertise are in any of the fifteen topics presented in this book will also find it appealing. It is also a valuable resource for postgraduate students, clinicians or anyone else who is curious about the role of carbohydrates in immunology, and would like to see the topics combined under one cover and in relation to each other.

Isobm Td-3 International Workshop on Monoclonal Antibodies Against Prostate Specific Antigen (Tumor Biology)

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Isobm Td-3 International Workshop on Monoclonal Antibodies Against Prostate Specific Antigen (Tumor Biology)

Manufacturer: Not Avail
ProductGroup: Book
Binding: Paperback

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ASIN: 3805569831

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Antibody Fusion Proteins

Manufacturer: Wiley-Liss
ProductGroup: Book
Binding: Hardcover

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ASIN: 047118358X

Book Description

Thoroughly detailed and illustrated, this book examines the construction, properties, applications, and problems associated with specific types of fusion molecules used in clinical and research medicine. The editors present an overview of the field, followed by nine chapters divided into two general sections based on the two primary parts of the antibody molecule: Fab fusion proteins and Fc fusion proteins. In addition, numerous renowned scientists in the field have contributed outlines demonstrating man-made molecules that will be required not only to overcome the limitations of monoclonal antibodies, but also to extend the principle of selective targeting.

Divided into specific, accessible sections, Antibody Fusion Proteins includes:
* Chapters describing Fc fusion proteins, as well as several classes of antigen-binding proteins
* Complete details on the design and molecular construction of genetically engineered fusion molecules
* Useful information on molecular purification, large-scale production, practical applications, and their therapeutic potential
* The latest data on forming fusion proteins with toxins, cytokines, or enzymes that can activate a prodrug

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Catalytic Antibodies

Manufacturer: Wiley-VCH
ProductGroup: Book
Binding: Hardcover

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ASIN: 3527306889

Book Description

Exploiting the inherent combinatorial mechanism in the biosynthesis of antibodies, an almost limitless variety of biocatalysts may be generated. Catalytic antibodies are capable of performing almost any type of reaction with high selectivity and stereospecificity.

Here, the pioneers in the use of catalytic antibodies review the entire scope of this interdisciplinary field, covering such topics as:

theoretical aspects of structure, mechanism and kinetics
practical considerations, from immunization techniques to screening methods
in vitro evolution and other modern approaches
applications from organic synthesis to medical uses.

Backed by the leading authorities in antibody catalysis, this is the first book to provide such comprehensive coverage and will be the prime reference for biochemists, organic chemists, biotechnologists and biomedical researchers.

Antibody Engineering: Methods and Protocols (Methods in Molecular Biology)

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Antibody Engineering: Methods and Protocols (Methods in Molecular Biology)

Manufacturer: Humana Press
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Binding: Hardcover

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ASIN: 1588290921

Book Description

A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.

alpha-Gal and Anti-Gal: alpha-1,3-Galactosyltransferase, alpha-Gal Epitopes and the Natural Anti-Gal Antibody (Subcellular Biochemistry)

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alpha-Gal and Anti-Gal: alpha-1,3-Galactosyltransferase, alpha-Gal Epitopes and the Natural Anti-Gal Antibody (Subcellular Biochemistry)

Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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ASIN: 030646103X

Book Description

This is an interdisciplinary book which for the first time assembles the wide spectrum of information on the basic and clinical aspects of the natural anti-Gal antibody, the alpha-gal epitope and the enzyme producing it, alpha-1,3-galactosyltransferase.
Anti-Gal is the most abundant antibody in humans, apes and Old World monkeys (monkeys of Asia and Africa). It binds specifically to the alpha-gal epitope (Galalpha1-3Galbeta1-4GlcNAc-R) on glycoproteins and glycolipids. Humans, apes and Old World monkeys lack alpha-gal epitopes. In contrast, the alpha-gal epitope is produced in large amounts on cells of nonprimate mammals prosimians and New World monkeys (monkeys of South America), by the glycosylation enzyme alpha-1,3-galactosyltransferase. This differential distribution of the alpha-gal epitope and anti-Gal in mammals is the result of an evolutionary selective process which led to the inactivation of alpha-1,3-galactosyltransferase in ancestral Old World primates. A direct outcome of this event is the present rejection of xenografts such as pig organs in humans and monkeys because of the binding of human anti-Gal to alpha-gal epitopes on pig cells.
The various chapters in this book were contributed by researchers studying basic and clinically related aspects of this area. The book aims to provide comprehensive and updated information on this antigen/antibody system, which at present is the major obstacle in xenotransplantation, and on some of the genetic engineering approaches developed for overcoming this obstacle. In addition, this book describes the significance of anti-Gal and alpha-gal epitopes in some parasitic, bacterial and viral infections, as well as in the pathogenesis of autoimmune diseases such as Graves' disease. Finally, this book describes novel approaches for exploiting the natural anti-Gal antibody for increasing immunogenicity of cancer and viral vaccines in humans.
This book is edited and partly written by Dr. Uri Galili who originally discovered anti-Gal and the unique evolution of &agr;-1,3-galactosyltransferase, and by Dr. Jose-Luis Avila who has been studying anti-Gal significance in Chagas' disease and in Leishmania infections.
This book covers the main areas of research on &agr;-1,3galactosyltransferase, its product the &agr;-gal epitope (Gal&agr;1-3Gal&bgr;1-4GlcNAc-R) and the natural anti-Gal antibody that interacts with this epitope. The book includes chapters on: The evolution of &agr;-1,3 galactosyltransferase in mammals; the structure of the &agr;-1,3galactosyltransferase gene; the structure function relationship of the &agr; 1,3galactosyltransferase enzyme; the molecular characteristics of &agr;-gal epitopes on glycolipids and glycoproteins and methods for its detection; the natural anti-Gal antibody and its significance in xenotransplantation; attempts to prevent xenograft rejection by elimination of &agr;-1,3galactosyltransferase gene, and by modulating &agr;-gal epitope expression and anti-Gal activity; significance of anti-Gal and &agr;-gal epitopes in viral, bacterial and protozoal infections; and the possible clinical exploitation of anti-Gal for the enhancement of cancer and viral vaccine immunogenicity.

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