Genes VIII

Book Description

The unique feature of this book's first edition was the presentation of a unified approach to the molecular biology of prokaryotes and eukaryotes. The success of this approach, and its continuation, is the result of a long string of discoveries showing similarities in solutions to biological problems that often extend across many or even all species. A six-part organization covers genes, proteins, gene expression, DNA, the nucleus, and cells. For individuals in the science community interested in genetics.

Customer Reviews:

Molecular biology can be easy to learn.......2007-02-13

I have been using Genes VIII for a year already in my Molecular Biology studies and I should state that this is one of the best books written in this field.
First of all, the material is structured in a clear manner. Moreover all terms are introduced starting from simple things, which become harder and harder as you proceed. That gives the student the opportunity to form the overall picture of molecular biological processes.
Besides, each chapter starts with the introduction that is very useful when you want to review the things (i.e. before the exam).
In my opinion this book contains a lot of visual material that definitely helps students to understand the material more thoroughly.

To sum up, I would recommend everybody who wants to explore the world of Molecular Biology to buy this book.

One of the best.......2006-04-29

This text is a vast improvement on the previous editions. Its improved vastly on both clarity and content. The figures themselves are excellent learning tools. Combined with uptodate material, it is in my opinion peerless. Its rivals would be lodish and alberts but in some areas complements them and often outshines them. The textbook exists online at ergito.com and you could subcribe for the duration of your course. The website gives you access to the complete material in the print text and you also save a ton of money by subscribing for a shorter period, that is if you find cash an issue. However, I wholeheartedly recommend the print edition as a trusted companion for those embarking on graduate studies.

A great book on biology.......2004-12-03

Dr. Lewin's work has helped me understand biology and improve my understanding of the sciences. The design and figures in Genes are wonderfully clear, as is the general body of the text.

Furthermore, his website at ergito.com has some great supplemental material on the important procedures of science and past experiments that have changed sciences.

Between the Genes book and the subscription to Ergito, Dr. Lewin's work is a great opportunity to learn and expand your knowledge. I thought Genes VIII was great, and a good step forward from Genes VII.

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins

Average customer rating:

Somewhat more than an out-of-date catalog of tools
A survey for tool users
Bioinformatic for the beginner...
Poorly organized overpriced book
...

Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins

Manufacturer: Wiley-Interscience
ProductGroup: Book
Binding: Hardcover

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ASIN: 0471478784

Book Description

Reviews of the Second Edition
"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt."
--Eric Lander, from the Foreword to the Second Edition
"The editors and the chapter authors of this book are to be applauded for providing biologists with lucid and comprehensive descriptions of essential topics in bioinformatics. This book is easy to read, highly informative, and certainly timely. It is most highly recommended for students and for established investigators alike, for anyone who needs to know how to access and use the information derived in and from genomic sequencing projects."
--Trends in Genetics
"It is an excellent general bioinformatics text and reference, perhaps even the best currently available . . . Congratulations to the authors, editors, and publisher for producing a weighty, authoritative, readable, and attractive book."
--Briefings in Bioinformatics
"This book, written by the top scientists in the field of bioinformatics, is the perfect choice for every molecular biology laboratory."
--The Quarterly Review of Biology
This fully revised version of a world-renowned bestseller provides readers with a practical guide covering the full scope of key concepts in bioinformatics, from databases to predictive and comparative algorithms. Using relevant biological examples, the book provides background on and strategies for using many of the most powerful and commonly used computational approaches for biological discovery. This Third Edition reinforces key concepts that have stood the test of time while making the reader aware of new and important developments in this fast-moving field. With a new full-color and enlarged page design, Bioinformatics, Third Edition offers the most readable, up-to-date, and thorough introduction to the field for biologists.
This new edition features:
* New chapters on genomic databases, predictive methods using RNA sequences, sequence polymorphisms, protein structure prediction, intermolecular interactions, and proteomic approaches for protein identification
* Detailed worked examples illustrating the strategic use of the concepts presented in each chapter, along with a collection of expanded,more rigorous problem sets suitable for classroom use
* Special topic boxes and appendices highlighting experimental strategies and advanced concepts
* Annotated reference lists, comprehensive lists of relevant Web resources, and an extensive glossary of commonly used terms in bioinformatics, genomics, and proteomics
Bioinformatics, Third Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, clinical research, proteomics, and computational biology.

Customer Reviews:

Somewhat more than an out-of-date catalog of tools.......2004-03-27

The book is a collection of chapters by different authors addressing software tools for various problems: database search, multiple sequence alignment, gene prediction, protein structure prediction, etc. A big flaw is that all of the authors assume a different level of prior background and have rather different emphases.

I'd have to agree with the other reviewer that Chapters 1 & 17, which constitute 10% of the book, are wasted paper. No one in 2001 (when the book was published), let alone 2004, needs Chapter 1's lengthy explanation of what e-mail and web browsers are. And the perl program at the anticlimax of Chapter 17 was ... anticlimactic.

The book is to a great extent a catalog of available software tools. With the exception of the chapters on multiple alignment and phylogeny, the emphasis is on not on how the tools work but how to operate them -- to the of saying "at this URL there is a web page where you can either paste in your sequence or upload a file". The idea of invoking a program through a Unix command line is more than once presented as a truly daunting prospect. The authors generally do a good job of emphasizing that the programs are the beginning of analysis and not the end; the results must always be viewed somewhat skeptically with an expert eye.

If you're coming at the book as a biologist, you will probably find it to be a useful catalog of software, though undoubtedly dated by now. If you're coming at it from the informatics side, you're going to need some background... a book like Dwyer's, Setubal and Meidanis's, or Mount's will get you up to speed on the algorithm aspects of the field with simplified versions of many of the big problems. Then you can look at this book to find good pointers to the ways the real-world versions have been addressed.

The book was published three years ago and, being to a large extent an index of the work of others, is necessarily no longer up to date in a fast-moving field. It needs a revision and, in the meantime, it would make more sense to snag a used copy than to pay full price for a new book.

A survey for tool users.......2003-10-09

Like any survey, it seems to touch the major features only. And, as others have pointed out, the tools change but the book doesn't.

I think this is a good, brief introduction to the wide variety of bioinformatic tools and databases on the internet. It describes the major features of each, and the kinds of results that each tool is good for. After that, the serious user will go to the sources of each tool or database, to learn more about the specifics as of the moment. No book can hope to keep up with the weekly enhancements at the major repositories.

I emphasize that this is for tools users, not tool makers. It addresses the working scientists who already know their subjects and their needs. This skips over the algorithms in favor of higher level descriptions, and skips over many of the biological reasons for the tools described. Better-informed tool users get better answers from the tools, true. At some point, though, the biologists want to skip the theory, skip the introduction to subjects in which they're experts, and get on with their science. I don't think this book was ever meant for people - and I'm one - who want full details of the algorithms.

I agree, the book treats its many subjects in a shallow way. I think that is by intent, since the book's real goal is breadth and its target is a reader who knows the basic science. It's a bit off the center of my interests, but I've found it helpful.

Bioinformatic for the beginner..........2003-01-31

I guess that everybody interrested by this kind of book knows already a little about bioinformatic and wants to improve his bioinformatician skill. So forget about this book:
This is really a well-documented introduction to all the methods currently used by every biologist or biology student, such as Blast, Clustal, multiple alignement or use of web-interface for submiting sequence.
So get it if you need a clear introduction to the field, but if you already know a little bit about bioinfo, immediately choose a more detailed book.

Poorly organized overpriced book.......2002-09-30

Although the book is presented as an introduction to the topic, its organization assumes that the reader has already been working in the area. Two of the chapters (1 and 17) are a waste of space. The first chapter presents a (useless) introduction to internet, while chapter 17 attempts (and fails to do so) to explain Perl in the context of bioinformatics. For the same money you can find far better books in the market. The good thing is that I only borrowed the book :)

..........2002-06-27

I used the Baxevanis volume in coursework at Johns Hopkins Biotechnology program...several of the chapter authors are associated with the school. There's no doubt that the editor and authors are experts in their fields, but the volume seems somewhat dated, and is disjointed. I found a couple of the chapters virtually unreadable. The real killer is the price. The book is GROSSLY overpriced...

Book Description

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies.

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Customer Reviews:

general introduction book for biological science.......2004-03-26

This book is only provided general information for biological science.The main part is focus on the drug information, which can be found in the public resources.Little information is mentioned about how to develop a new drug.Thus, it is suitable for undergranduate student reading, not for academic research.

Useful Book.......2003-08-06

"...faculty that teach in the pharmaceutics curriculum will find the Ho and Gibaldi text of great value as course content is revised and new areas are added and expanded. The book provides important linkages between the science and therapeutics of biotechnology products that faculty will find useful in integrating the subject matter in health sciences and graduate program curricula." --Stuart Feldman, Ph.D., Biomedical and Health Sciences Institute and Department of Pharmaceutical and Biomedical Sciences, University of Georgia, Athens, Georgia

Disappointingly written and edited.......2003-07-04

This book appears to me to be very poorly edited, with numerous clerical and scientific errors. For instance, multiple sclerosis is termed a "neurogenerative" disease rather than a "neurodegenerative" disease. The writing includes some of the longest sentences I've ever seen in scientific writing, and not to the author's benefit. The authors repeat themselves quite a bit from one chapter to the next. Disappointing!

Directed Enzyme Evolution: Screening and Selection Methods (Methods in Molecular Biology)

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Directed Enzyme Evolution: Screening and Selection Methods (Methods in Molecular Biology)

Manufacturer: Humana Press
ProductGroup: Book
Binding: Hardcover

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Directed Evolution Library Creation: Methods and Protocols (Methods in Molecular Biology)

ASIN: 158829286X

Book Description

Seasoned practitioners from many leading laboratories describe their best readily reproducible screening strategies for isolating useful clones. These techniques have been optimized for sensitivity, high throughput, and robustness, and are of proven utility for directed evolution purposes. The assays presented use a variety of techniques, including genetic complementation, microtiter plates, solid-phase screens with colorimetric substrates, and flow cytometric screens. An accompanying volume, Directed Evolution Library Creation: Methods and Protocols (ISBN 1-58829-285-1), describes readily reproducible methods for the creation of mutated DNA molecules and DNA libraries.

Copy for Both Volumes

Directed Evolution Library Creation: Methods and Protocols and Directed Enzyme Evolution: Screening and Selection Methods constitute an extraordinary collection of all the key methods used today for directed evolution research. Described in step-by-step detail to ensure robust experimental results, these methods will enable both newcomers and more experienced investigators to design and implement directed evolution strategies for the engineering of novel proteins. The first volume describes methods for the creation of mutated DNA molecules, or DNA libraries, encoding variants of desired proteins. The second volume describes methods for screening DNA libraries to isolate mutant proteins that exhibit a specified function.

Cloning, Gene Expression, and Protein Purification: Experimental Procedures and Process Rationale

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Cloning, Gene Expression, and Protein Purification: Experimental Procedures and Process Rationale
Charles Hardin , Jennifer Edwards , Andrew Riell , David Presutti , William Miller , and Dominique Robertson
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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Molecular Biology

ASIN: 0195132947

Book Description

On the forefront of modern scientific innovation, Cloning, Gene Expression and Protein Purification: Experimental Procedures and Process Rationale effectively doubles as a laboratory manual for students and a reference book for professional researchers. Designed for advanced undergraduate and beginning graduate students in molecular biology, this unique combination lecture/laboratory resource presents detailed protocols for the multi-step process involved in isolating a gene, cloning and characterizing it, expressing its encoded protein, and purifying and characterizing the protein's basic physical properties. This manageable volume includes both theoretical background and practical procedures and is structured around twenty experiments that demonstrate how to prepare, manipulate, and analyze plasmids, produce fusion proteins in bacteria, and purify these proteins based on unique chemical properties or substrate affinities. The book describes advanced topics such as the use of antibodies and the techniques developed to transform their structures, as well as combinatorial approaches designed to manipulate the structure and functions of proteins and nucleic acids. Supplemental literature provides a variety of theoretical explanations encouraging a more intuitive understanding of the experimental mechanisms and behaviors of the chemical participants, while also giving students the tools needed to become "capable proactive researchers." Features: DT Emphasizes electrophoresis, Southern and Western blotting, and combinatorial techniques DT Defines clear reaction mechanisms; stipulates the functions of reagents; and helps students think about the precise consequences of solution and procedural manipulations DT Discusses fluorophores, and solvent effects on protein structure DT Characterizes plasmids, cDNAs, and antibody probes (available from ATCC) in research literature DT Includes carefully selected primary source research literature and articles from current vendor literature DT Contains a glossary of unfamiliar phrases and jargon; important summary statements and conclusions are italicized DT Provides an alphabetized list of common reagents for rapid reference DT Offers an extensive index of concepts and terms DT Categorizes helpful and distinctive information into five types of supplemental literature: Innovation/ Insight, Theory/Principle, Process Rationale, Vendor Literature, and Alternative Approaches

Applications of Chimeric Genes and Hybrid Proteins, Part C: Protein-Protein Interactions and Genomics (Methods in Enzymology, Volume 328) (Methods in Enzymology)

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Applications of Chimeric Genes and Hybrid Proteins, Part C: Protein-Protein Interactions and Genomics (Methods in Enzymology, Volume 328) (Methods in Enzymology)

Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 012182229X

Book Description

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

Genes Proteins Cellular Aging: (Benchmark Papers in Genetics)

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Genes Proteins Cellular Aging: (Benchmark Papers in Genetics)
Holliday
Manufacturer: Van Nostrand Reinhold Company
ProductGroup: Book
Binding: Hardcover

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The GTPase Superfamily -No. 176 (CIBA Foundation Symposia Series)

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The GTPase Superfamily -No. 176 (CIBA Foundation Symposia Series)
CIBA Foundation Symposium
Manufacturer: John Wiley & Sons
ProductGroup: Book
Binding: Paperback

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Book Description

The GTPase Superfamily Chairman: Frank McCormick 1993 GTPases are enzymes that use GTP hydrolysis to drive the sequential binding of molecules to a series of reaction partners. They play important roles in ribosomal protein synthesis, translocation of nascent proteins into the endoplasmic reticulum, transmembrane signalling by hormones and light, the control of differentiation and cell proliferation, and the targeting of vesicular traffic within cells. GTPase activity is also associated with two of the mechanochemical enzymes, dynamin and tubulin, that generate force for intracellular movement. Although GTPases fulfil such diverse functions, they are related by the possession of distinct, highly conserved sequence motifs that encode the guanine nucleotide-binding domain. Rapid advances in determining the crystal structures of some of the superfamily members have shed light on the nature of this region, which allows the protein to act as a molecular switch. This switch mechanism, turned `on' by the binding of GTP and `off' by the hydrolysis of GTP to GDP, appears to have arisen early in evolution and has since been adapted to suit a variety of functions in the cell. If the GTPase switch is damaged, or locked `on' then a number of diseases, including cancers, can arise. The effector proteins with which GTPases interact and their downstream target molecules are now being identified: this book contains recent information on these and discussion of their importance in different cellular functions. The various regulatory proteins that modulate GTPase activity are also described by some of the leading biochemists, geneticists and cell and molecular biologists from this field. Other recent Ciba Foundation Symposia: No. 164 Interactions among cell signalling systems Chairman: Y. Nishizuka 1992 ISBN 0 471 93073 3 No. 167 Polyfunctional cytokines: IL-6 and LIF Chairman: D. Metcalf 1992 ISBN 0 471 93439 9 No. 170 Regulation of the eukaryotic cell cycle Chairman: T. Hunter 1992 ISBN 0 471 93446 1

Glowing Genes: A Revolution In Biotechnology

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Great reading for science buffs and lay people alike!
MUCH better than your average pop science book.
A fun tour of discovery
Wow - Can they really do that?
Bioluminescence

Glowing Genes: A Revolution In Biotechnology
Marc Zimmer
Manufacturer: Prometheus Books
ProductGroup: Book
Binding: Hardcover

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ASIN: 1591022533

Book Description

"Dr. Zimmer has written the first overview of one of history's most important revolutions in biology and medicine....The wonderful future that fluorescent proteins will bring us cannot even be imagined at this point." ROBERT M. HOFFMAN, PhD. President, AntiCancer, Inc.

"Marc Zimmer tells the fascinating story about how a curiosity of nature, animals that glow in the night, has led to major technological advancements in the molecular biology revolution. This book reveals how academic inquiry can improve the quality of our lives in surprising ways." KEITH WOOD, Research Fellow, Promega Corporation

"This book provides a striking example of how results of basic fundamental research can lead to extensive, wide-ranging, practical applications exceeding the wildest expectations of those making the initial findings. Many countermeasures currently being developed against chemical and biological threats posed by international terrorism rely directly or indirectly upon the discoveries described so elegantly in this book." KEITH B. WARD, PhD. Science Advisor and Program Manager, Homeland Security Advanced Research Projects Agency US Department of Homeland Security

"An illuminating review of a family of molecules that has revolutionized biomedical science and is beginning to do the same to our daily lives." RANDALL PRATHER, Distinguished Professor of Reproductive Biotechnology, University of Missouri-Columbia

"The discovery and development of green fluorescent protein has had profound impact on molecular biology research, which Zimmer conveys with considerable insight and aplomb." KEVIN DAVIES, PhD, Author of CRACKING THE GENOME and editor-in-chief of BIO-IT WORLD

"This book is written in an original manner to be interesting and clear to a very broad and diverse audience, from inquisitive housewives to scientists." DR. SERGEY A. LUKYANOV, Head of the Laboratory of Genes for Regeneration, Russian Academy of Science.

Customer Reviews:

Great reading for science buffs and lay people alike!.......2007-02-14

Dr. Zimmer's book is enlighting and warm. His antecdotes are charming as is his web site where I found out about the book and ordered it. Thank you Marc.
Zack's Mom

MUCH better than your average pop science book........2005-06-14

I have to say that this was a very poorly edited book littered with bizarre mistakes: grammatical, spelling, and elementary history (the introduction talks about 17th century Victorian ladies!). The writing style veers from something targeted at teenagers to something more adult and back again, sometimes in one paragraph.

Having said that, this book really is worth reading, in spite of the style, because the science it describes is riveting. I was vaguely aware of fluorescence as something used by biologists, but the author really does a great job of covering the field; the history, the various ways in which fluorescence is used, the ways in which the essential chemistry of the subject has been modified over the past few years. I'm a sucker for pop science books but, sadly, most of them rehash material that any educated person should already know. It's rare to find one, like this, that not only is packed with material that I did not know but that also manages to weave it all into a coherent narrative.

A fun tour of discovery.......2005-04-13

It's a long time that I have been so fascinated by a popular science book as now happened, reading "Glowing Genes". Marc Zimmer neatly explains what one needs to know about genetics and chemistry. But that is not all. Since I read the book a few weeks ago,
· I have become more sensitive to and interested in the benefits of research done for the sake of discovering secrets of nature, as opposed to primarily profit motivated research.
· I believe to understand that not all cloning of animals is harmful, that the pros and cons have to be weighed in each case,
· And having read "Glowing Genes" and Bill Bryson's "A short history of nearly everything", I often wonder how many inventors and first discoverers are forgotten or intentionally not recorded.
Reading "Glowing Genes" is a fun-tour of discovery. My mostly outdated High School Science seems to have been enough background to understand the well explained complex issues. I did have problems though with chapter 12. Perhaps I should read it once more.

Wow - Can they really do that?.......2005-04-06

I bought this book because I was fascinated by the pictures on the cover and read it to see if scientists can really make pigs with glowing noses. They can and they can do so much more. This book was very interesting and was easy to read. I finished it in one go. The author acknowledges Bill Bryson as one of his influences and you can clearly see that in his writing style ...perhaps thats why I enjoyed it so much. Glowing Genes also has cool pictures of a glowing bunny and fluorescent fruit fly sperm. It presents the complete story of GFP and the firefly protein - from the early scientists who caught 1000's of jellyfish and fruit flies to the newest applications. Read it, you will enjoy it.

Bioluminescence.......2005-03-01

I must admit I haven't read this book yet but I did have Marc Zimmer as a professor in college and he was a fascinating man with very interesting ideas. I am possitive that this book will be nothing less than great! If you're reading this review, chances are that you're a least someone interested in the topic of bioluminescence, and that's the case, then I highly recommend you give this book a read! Professor Zimmer lectured on this topic and the technology and possibilites are AMAZING!!!

Bioinformatics: Genes, Proteins and Computers (Advanced Text)

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Bioinformatics: Genes, Proteins and Computers (Advanced Text)
C. A. Orengo
Manufacturer: Garland Science
ProductGroup: Book
Binding: Paperback

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ASIN: 1859960545

Book Description

The Advanced Text series is designed for students taking advanced-level courses, including upper-level undergraduates and graduate students. Titles in this series will also be invaluable to researchers new to a field, and to established researchers as a basic reference text.

Bioinformatics covers both the more traditional approaches to bioinformatics, including gene and protein sequence analysis and structure prediction, and more recent technologies such as datamining of transcriptomic and proteomic data to provide insights on cellular mechanisms and the causes of disease.

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