Average customer rating:
- great
- Fascinating material
- Good introductory material for the technical
- Good overview but lacks technical rigor
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Molecular Biotechnology: Principles and Applications of Recombinant DNA
Bernard R. Glick , and
Jack J. Pasternak
Manufacturer: ASM Press
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ASIN: 1555812244 |
Book Description
Completely revised and updated, this second edition of the best-selling Molecular Biotechnology covers both the underlying scientific principles and the wide-ranging industrial, agricultural, pharmaceutical, and biomedical applications of recombinant DNA technology. This new edition includes expanded coverage of the types of organisms and cells used in molecular biotechnology, DNA, RNA, and protein synthesis, the methodology and applications of genetic engineering of plants, and microbial production of therapeutic agents. Updated chapters reflect recent developments in biotechnology and the societal issues related to it, such as cloning, gene therapy, and patenting and releasing genetically engineered organisms. "Milestones" summarize important research papers in the history of biotechnology and their effects on the field. TABLE OF CONTENTS: Fundamentals of Molecular Biotechnology The Molecular Biotechnology Revolution Molecular Biotechnology Biological Systems DNA, RNA, and Protein Synthesis Recombinant DNA Technology Chemical Synthesis, Sequencing, and Amplification of DNA Manipulation of Gene Expression in Prokaryotes Recombinant Protein Production in Eukaryotic Cells Directed Mutagenesis and Protein Engineering Molecular Biotechnology of Microbial Systems Molecular Diagnostics Microbial Production of Therapeutic Agents Vaccines Synthesis of Commercial Products by Recombinant Microorganisms Bioremediation and Biomass Utilization Plant Growth-Promoting Bacteria Microbial Insecticides Large-Scale Production of Proteins from Recombinant Microorganisms Eukaryotic Systems Genetic Engineering of Plants: Methodology Genetic Engineering of Plants: Applications Transgenic Animals Human Molecular Genetics Human Gene Therapy Regulating and Patenting Molecular Biotechnology Regulating the Use of Biotechnology Patenting Biotechnology Inventions
Customer Reviews:
great.......2007-01-04
I found the the book in a very good shape. I'm very much satisfied.
Fascinating material.......2005-06-18
I used this book for one of my favorite classes in college on biotechnology. It will show you the cool side of science and all of the neat things you can do with biology and DNA. The level is low enough to where you only need a minimal background to understand it, basic biology classes and preferably genetics. After completing the book you should be excited about the future of biotech, and you will have some understanding about how it works.
Good introductory material for the technical.......2001-05-11
To those who are interested in the functional aspects of the DNA this is the right introductory stuff. It covers areas including basic molecular biology to commercial methods for manipulating the genes. Pretty useful for someone who's more interested in the technology than the biology!
Good overview but lacks technical rigor.......2000-04-07
I am currently using this book for a course in Molecular Biotechnology taught through the chemistry department. Although the book covers a wide range of biotechnology fields, from manipulation of gene expression in prokaryotes and eukaryotes through human gene therapy, it does so in a somewhat shallow and repetitive way. I have also seen clearer and more concise diagrams covering similar topics in other biochemistry books, and there is a paucity of in-depth coverage in any particular area. This is not necessarily the authors's fault, however, arising from the plethora of information found in the biotechnology field. If someone wants a broad review of molecular biotechnology, this is a decent book, but if you want to focus on a specific area within biotechnology, look somewhere else.
Book Description
In the rapidly advancing science of genetics, currency and accuracy are critical in any book. This book presents the most up-to-date developments in genetics as well as the fundamental principles. It stresses how genetics is done and provides historical and biographical insights to the people and events that have made genetics a pre-eminent science. The new edition incorporates organizational changes to make the book more modern, including earlier DNA coverage. A new design also highlights numerous practice problems that help reinforce important concepts.
* Provides a comprehensive and balanced view of both Classical Mendelian topics and modern Molecular topics.
* Incorporates the latest findings from Genomics and Proteomics.
* Includes numerous high-quality illustrations with stepped-out art to help readers visualize complex processes.
* Offers the analytical tools that readers will need for problem solving.
Customer Reviews:
Well written........2007-05-23
When I was getting a very brief introduction of genetics in my Biology book by Raven, for some reason I was just not understanding what the hell I was reading. This book is easy to grasp, very well written. I highly recommend it to anyone, also, the CD is pretty good.
it was great.......2007-03-09
this book helped me a lot. i used the book for its extra problems which they were great.
Great Purchase.......2005-09-01
There was no marks in the whole book, and the price was great.
The best introductory text broadly covering the field.......2003-07-11
I would rate this as one of the best (if not the best) introductory texts in genetics. Comparing this to various other material that I've come across, Snustad and Simmons definitely exhibit superior aptitude in educational skills in this work. They have a firm grasp of what their target readers can understand and know how build up the readers' progressive comprehension while keeping the interest level high. This is the true mark of a well-constructed textbook. We all know how boring some texts can be, but I found myself always itching to read on and even go backward to review some of the concepts. The authors' use of simple language (unlike some other "introductory" texts) makes reading somewhat "light and fun" in contrast to some others who seem to not be as adept in communicating to "pre-PhD" students.
Another characteristic that makes this work stand out is it's sheer beauty. The illustrations, photographs, charts, and even the layout are absolutely gorgeous! Hey, I'm not one who judges a book by the cover, but even the cover is beautiful! The artwork is well thought out and easy to understand. Many parts of the text can be reviewed plainly by looking at the pictorial descriptions without necessitating too much re-reading of the sections.
The authors also include well-placed "sidelights" throughout the book to help the reader get a "real-life" connection to subject. And the sidelights are mostly about what we care about most...ourselves. Thus, in addition to constant reference to medical applications here and there, the sidelights help the reader appreciate what genetics is all about.
Another important aspect of this text is that it is up to date. The authors have taken into consideration the exponential advances in the field and documented it here. That is just one more plus to this already fantastic piece of work!
i want to review this book again.......2003-01-22
i have read this book once but i am very keen to read again this book so i want to read this book and for that i want to see the review of this book.
Book Description
This Updated 7th edition features a new section, "Genetic Control," at the end of the text. This section complements Cummings' coverage with a series of cases from noted medical ethicist, Dr. Ronald Munson, which investigate the issues surrounding the stem-cell debate, genetic counseling, genetic testing and reproductive decisions, and gene therapy. These cases are reinforced with original readings from other noted geneticists, ethicists, and medical policy makers. The result is a text that will draw students into the most current research in genetics and educate them on the latest challenges facing physicians, researchers, and society. Instructors will find this Seventh Edition of HUMAN HEREDITY current, clear, and complemented by an amazing array of technology for students and instructors. Additional student support includes Human GeneticsNow, a password-protected website integrated with the Seventh Edition that provides students with access to diagnostic Pre-Tests and Post-Tests for each chapter. It automatically generates customized learning plans for students, directing them to text information and ancillaries that help them master specific concepts. Active Figures in the text, indicated by a media icon, have corresponding narrated animations on the Human GeneticsNow site that are included in the customized Learning Plan along with additional animations and media assets. For instructors, a Multimedia Manager provides all of the art and photos from the text in PowerPoint form, and, lectures can be further enhanced by using animations and videos on human heredity topics.
Customer Reviews:
Good Into Book.......2007-07-25
One of the better intro books I've read. Has a lot of info in an easy to read manner.
Great book on genetics.......1999-05-03
This book effectively conveys interesting, detailed material without confusing the reader. It is not the typical staugy textbook that we college students are so use to as this book made me want to read it, it was so enjoyable. I recommend it to all college students or anyone interested in genetics that would like to understand our genetic principles.
An accurate and concice look into Human Genetics........1998-03-17
This is a wonderful book for a college level exploration of Human Genetics. The chapters introduce every topic well, and in such a way that science majors will remain interested while non science majors aren't left behind. It is a great book to begin to explore the wonders of Human Genetics.
Book Description
Text with Continually Updated Online Reference! The most definitive and trusted reference in medical genetics is back-complete with state-of-the-art web site! The fifth edition of this comprehensive yet practical resource emphasizes application as well as the theory of medical genetics across the full spectrum of inherited disorders. Get expert clinical advice and guidance from over 250 of the world's most trusted authorities in medical genetics. The E-dition features the 5th edition of the textbook, additional new images, weekly updates, and more! With the latest information on prenatal diagnosis, genetic screening, genetic counseling, and treatment strategies, Principles and Practice of Medical Genetics will be an invaluable clinical tool for the practicing physician.
Customer Reviews:
Genetics:' creme de la creme.......2007-03-12
I ordered a number of competitor volumes for comparison, and this is simply the best of the group. Yes, it's expensive, but worth every penny. The online access is an added bonus for quick access when away from these heavy volumes. Superb photographs, illustrations, and content!
Book Description
Principles of Population Genetics, Third Edition, provides a balanced presentation of theory and observation for students at the undergraduate and graduate levels. In response to suggestions from students and instructors, the book has been trimmed more than 100 pages and rewritten with the goal to optimize its use as a teaching aid. It introduces the principles of genetics and statistics that are relevant to population studies, and examines the forces affecting genetic variation from the molecular to the organismic level. Integrated throughout the book are descriptions of molecular methods used to study variation in natural populations, as well as explanations of the relevant estimation theory using actual data. Chapter 1 presents the fundamental genetic and statistical concepts in population genetics. Chapter 2 reviews the types and prevalence of genetic variation in natural populations. This is followed in Chapter 3 by a detailed examination of the implications of random mating for one locus and multiple loci. Chapter 4 examines population subdivision and its consequences for the distribution of genetic variation among subpopulations, including the hierarchical F statistics used in estimating these effects. Chapters 5 through 7 deal with mutation, migration, natural selection in all its varieties, and the consequences of random genetic drift. Molecular population genetics, including coalescent theory, is the subject of Chapter 8. Quantitative genetics is covered in Chapter 9, from the standpoint of genetic variance and covariance components as well as with respect to molecular markers used to detect quantitative trait loci (QTLs). Applications of principles discussed in the text are illustrated by numerous examples of worked problems, using actual data. Each chapter end, in addition to a complete summary, offers several problems for solution, to reinforce and further develop the concepts.
Customer Reviews:
Principles of Population Genetics.......2007-01-28
It is a classical text, but it lack of a chapter on Conservation Genetics
Check covers.......2005-09-22
Comparing this book with others purchased before this is in a very bad condition. I have to fix the cover.
A must-own........1998-02-06
A new revision of a work I already thought perfect. Adds population genetic approaches using new molecular techniques. Superb.
Book Description
Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: DT Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. DT A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. DT Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. DT Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. DT Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. DT Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 and 14-9), whose meanings are elucidated as the reader progresses through the book.
Customer Reviews:
Biology of Aging: Observations & Principles.......2006-03-09
It was exactly the edition I needed for my Biology of Aging course. It was delievered on time by Amazon
WOW!.......2002-10-18
I got this book because I used to do work on the author's lab and I was amazed by the work they were pursuing there.
I have read other bio textbooks, but what strikes me most about this one is that if you really just want to read one, this one has got it all. It is a complete survey, of all that is known and being studied currently on the topic of aging. From how to study aging to the goals of society in aging to everything inbetween. From the stuff that works, to might works, to absolutely does not, this is an excellent overview of the field.
Book Description
This thoroughly revised and expanded edition of a highly praised classic, The Principles of Clinical Cytogenetics, includes the many advances that have occurred in the field. Among the highlights are a full section devoted to advances in fluorescence in situ hybridization (FISH) technology, increased coverage of cancer cytogenetics-both hematopoietic neoplasms and tumor cytogenetics-and new chapters on chromosome instability and the cytogenetics of infertility. The book offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, and cytogeneticists the clear understanding they need to carry out and interpret their test results rapidly.
Customer Reviews:
very happy.......2007-09-05
I am very happy with service I recieved from amazon. This book was my 1st purchase but I am planning on making more purchases, because its relible, cheap and most importantly secure. I recommend using amazon to all the people out there.
Thanks
Must have........2005-08-02
If you are in that business or you are studing to get into that profession these are your fundations of knowladge. Great book new edition is updated, however don't discard old one.
Book Description
Until recently, plant breeders have depended primarily on classical tools to develop new and improved products for producers and consumers. However, with the advent of biotechnology, breeders are increasingly incorporating molecular tools in their breeding work. In recognition of the current state of methods and their application, this text introduces both classical and molecular tools for plant breeding.Topics such as biotechnology in plant breeding, intellectual property, risks, emerging concepts (decentralized breeding, organic breeding), and more are addressed in this state of the art text. The final 8 chapters provide a useful reference on breeding the largest and most common crops. In addition, over 25 plant breeders share their professional experiences while illustrating concepts in the text.
Average customer rating:
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Evolutionary Algorithms in Molecular Design (Methods and Principles in Medicinal Chemistry)
Manufacturer: Wiley-VCH
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ASIN: 3527301550 |
Book Description
When trying to find new methods and problem-solving strategies for their research, scientists often turn to nature for inspiration. An excellent example of this is the application of Darwin's Theory of Evolution, particularly the notion of the 'survival of the fittest', in computer programs designed to search for optimal solutions to many kinds of problems. These 'evolutionary algorithms' start from a population of possible solutions to a given problem and, by applying evolutionary principles, evolve successive generations with improved characteristics until an optimal, or near-optimal, solution is obtained.
This book highlights the versatility of evolutionary algorithms in areas of relevance to molecular design with a particular focus on drug design. The authors, all of whom are experts in their field, discuss the application of these computational methods to a wide range of research problems including conformational analysis, chemometrics and quantitative structure-activity relationships, de novo molecular design, chemical structure handling, combinatorial library design, and the study of protein folding. In addition, the use of evolutionary algorithms in the determination of structures by X-ray crystallography and NMR spectroscopy is also covered.
These state-of-the-art reviews, together with a discussion of new techniques and future developments in the field, make this book a truly valuable and highly up-to-date resource for anyone engaged in the application or development of computer-assisted methods in scientific research.
Average customer rating:
- Absolutely Terrific
- Pretty good content, although sometimes not well written
- Excellent overview of a very exciting field
- Genetic manipulation
|
Principles of Gene Manipulation
Sandy B. Primrose ,
Richard M. Twyman , and
Robert W. Old
Manufacturer: Blackwell Publishing, Incorporated
ProductGroup: Book
Binding: Paperback
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An Introduction to Genetic Engineering (Studies in Biology)
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Gene Cloning and DNA Analysis: An Introduction
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ASIN: 0632059540 |
Customer Reviews:
Absolutely Terrific.......2004-04-13
This text is just really great. The choice of words that go into the explanations are top notch. This was the requred textbook in my recombinant DNA course.
It is written by biologists for biologists; very technical very exact; again just absolutely terrific for both review and in depth understanding.
The only downfall I would say is that the Index isn't as good as it could be, but other than that I think every biology graduate student should own it....yeah its that good IMHO.
Pretty good content, although sometimes not well written.......2003-02-28
A very good book under the point of view of the content. A student facing the field for the first time will enjoy the "historical" overview given in the first half of the book, whereas those with more experience will still appreciate the description of the latest technologies.
However, the book has been written by several "hands" and could have used better editing: there are way too many repetitions and redundancies. Syntax-wise, sometimes the odd sentence is pretty obscure, too.
Excellent overview of a very exciting field.......2002-05-19
Certainly one of the most exciting developments in the last quarter century, genetic engineering is also one of the most controversial, and discussions of it are typically accompanied by vehemence and exaggerations. An objective study of genetic engineering is thus mandatory for everyone in the 21st century. This book is one of the best treatments of genetic engineering that I have read, and I am speaking not as a biologist but as someone actively involved in bioinformatics and computational biology. The explanations of the techniques of genetic engineering are excellent and the reader with a fairly good background in biochemistry should have no problem following the presentation. Readers without such a background will find the reading a little more demanding. One can only admire the ingenuity of the many researchers and technicians who have developed these techniques. The only thing missing in the book are exercises at the end of each chapter to test the readers understanding of the relevant concepts.
The last five chapters of the book are the most interesting ,for it is in these chapters that the authors discuss the genetic manipulation of animals, transgenic strategies, and biotechnology. We are all priveleged to be witnessing the development of new breeds of plants and animals, and hopefully this trend will continue in the 21st century. The impact of genetic engineering for medicine and agriculture will be immense, but even more mundance activities such as gardening and horticulture will be even more interesting with the development of new kinds of plants via transgenic strategies. In addition, genetic engineering is finding applications to areas outside of biology. It was recently reported that genetically engineered viruses are being used to assist in the development of quantum dots in microelectronics.
Some of the features of the book I found particularly helpful or interesting were: 1. The numerous diagrams employed in the book that tie concepts together or give flow charts for laboratory procedures. 2. The discussion on the physics of gel electrophoresis. Apparently the dynamics of stained molecules undergoing electrophoresis is poorly understood. 3. The historical and anecdotal information that the authors include at various places in the book. 4. The discussion on optimizing translation. The degeneracy of the genetic code might lead one to believe that the choice of codons by genes is essentially a random process. The authors argue this is not the case and give excellent references for further reading on this. Apparently protein translation is a tight scheme, and again, this is surprising given the degeneracy of the genetic code. 5. The box on express sequence tags. The most interesting part of this discussion was on the legal issues involving the patenting of ESTs. The patent applications were rejected because ESTs were viewed as incomplete sequences. This rejection might serve as a precedent to future attempts to patent genes or complete genomes. Will some of these patents be rejected on the grounds that genes do not completely determine the protein(s) or phenotype(s)? Whatever the outcome, the legal profession in the 21st century will have to deal with information-theoretic criteria when addressing patent issues in genetic engineering. 6. The listing of the Internet tools available for gene sequencing and protein structure. 7. The discussion on the quantitative effect of sequence accuracy on gene accuracy, assuming the random occurence of sequencing errors. The diagram shown of average sequence-error rate versus the fraction of error-free genes shows clearly the importance of robust and precise sequence-similarity search algorithms. Interestingly, the authors argue that, in spite of the success of statistical methods in these algorithms, the use of these methods will decrease as new sequences are accumulated and sequence conservation is used as the criterion for gene identification. They do however state that these methods will still remain useful for localizing frame shifts and for the choice of the initiation codon. 8. The box on the modes of replication of circular DNA molecules. The biophysicist reader will appreciate the discussion on the two types of replication: by theta-like structures or the rolling-circle type of mechanism. 9. The discussion on applications of transgenic mice, position effects, and transgene silencing. The authors discussion of the efficacy of transgenic strategies in mice progeny is fascinating in that some mice progeny has expression that was very different from that of the parents, or even absent. The authors give a brief discussion of boundary elements and matrix attachment regions with references for further reading. 10. The short discussion on transgenic fish. 11. The box on control of transgene expression in plants. 12. The discussion on the use of immunosuppressant drugs as chemical inducers of dimerization. The side effects of these drugs has prompted research into finding transgene induction strategies that do not have these side-effects. 13. The discussion on post-translational inducible protein activity. 13. The discussion on visible marker genes, especially the discussion on green flourescent protein. 15. The discussion on the use of antisense RNA to regulate gene expression in prokaryotes. 16. The discussion on the use of cosuppression in increasing the amount of pigment synthesized by petunia flowers. The application of transgenic strategies to horticulture is indeed exciting and one that will hopefully result in new varieties of houseplants and garden fruits and vegetables. 17. The discussion on the role of functional genomics. 18. Transgenic animals and plants as bioreactors: Tracy and her progeny in producing AAT. 19. Xenotransplantation. This is no doubt one of the most controversial techniques used in genetic engineering today.
Genetic manipulation.......1999-03-21
We are looking for information about genetic manipulatio
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