Book Description
Introduction to Protein Structure gives an up-to-date account of the principles of protein structure, with examples of key proteins in their biological context generously illustrated in full color to illuminate the structural principles described in the text. The first few chapters introduces the general principles of protein structure both for novices and for non-specialists needing a primer. Subsequent chapters use specific examples of proteins to show how they fulfil a wide variety of biological functions. The book ends with chapters on the experimental approach to determining and predicting protein structure, as well as engineering new proteins to modify their functions.
Customer Reviews:
Great for undergrads and graduate students.......2007-03-08
This book is very good at explaining the basics of proteins and their structure. Any student who plans on doing any sort of protein research should consider this a must have for their library.
The pictures are colorful and contain valuable easy to understand information. But the information shown is not over-crowded as some texts tend to do. The authors did not try to put too much information into one picture, but split the information between a number of illistrations.
The sections on protein folds, and motifs are a must for any one dealing with any kind of protein-protein, or protein-dna binding interaction. This will help scientists who will be using proteomic information to determine the structure and probable function of their protein when a crystal or NMR structure is not avaiable.
Great book for any biologist, biochemist, or physical chemist.
Excellent introductory text on Proteins.......2006-02-03
This is a great introductory text on protein science. It starts off with the basic chemistry of amino acids and polypeptides and goes from there into higher order structural organization of many proteins of many families. Reading this book allows one to think about protein function being a direct result of what the structure imposes. Although this is not a protein chemistry book, it's a great place to start appreciating how proteins do what they do following some elegant design principles.
The book gives interesting structural examples on how transcription factors use their DNA binding sites to recognize specific genomic sequences. Also, the story of how the voltage gated potassium channel can be orders of magnitude more selective for potassium over sodium is presented clearly. Overall, this book is necessary for any biologist doing protein related work, or anyone who wishes to gain more insight into how these tiny "machines of life" operate.
Basics of Protein Structure - Great for revision!.......2005-11-24
I used this book a lot for one of my undergraduate courses three years back. It's excellent at explaining the fundamentals of protein structure, it's written very clearly and the diagrams are easy to understand and appropriate. I found it particularly useful when studying immunology, the explanation of immunoglobulin structure, splicing, and mechanism of action was better than some of the other textbooks I used from the library. I finally bought a copy as reference and to aid revision of some basics while applying for research associate positions within the biochemistry field.
Indispensible for those interested to learn the essentials of protein structure.......2005-11-24
This book is one of the best books that addresses the topic of protein structure. The book answers nearly all the questions that anybody interested to know about protein structure. Meanwhile, the authers provided clear examples about how elucidating a protein structure can hint for its function(example, B-lactoglobulin structure similarity to retinol binding proteins hints for its function as retinol binding protein in the mammals intestine). Besides, the organization of the book chapters made it so easy to read. Above all, the versatile illustrative examples and figures that the authers used make reading this book is really enjoyable for people have the basic background in biochemistry or those who are interested to building skills in biochemistry as well. The chapeters describing prediction of protein structure and methods to determine the protein structrue are really so valuable as a basic introduction about these broad topics. With basic biochemistry skills, this book will be so enjoyable.
Nice experience with Amazon shopping.......2005-08-02
I tried to find some books in our university libraries and bookstores but failed, unexpectedly I found several in Amazon! Really amazing!
Average customer rating:
- Depressing
- The gears on the cover dont even work!
- Anonymous
- Very unhelpful book
- I normally buy books because they contain information...
|
Practical Introduction to Data Structures and Algorithms, Java Edition
Clifford A. Shaffer
Manufacturer: Prentice Hall
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ASIN: 0136609112 |
Book Description
The author, Cliff Shaffer provides a superior learning tool for those who desire more rigorous data structures and an algorithm analysis book utilizing Java. While the author covers most of the standard data structures, he concentrates on teaching the principles required to select or design a data structure that will best solve a problem. The emphasis is on data structures, and algorithm analysis, not teaching Java. Java is utilized strictly as a tool to illustrate data structures concepts and only the minimal, useful subset of Java is included.
Customer Reviews:
Depressing.......2007-07-14
This book gave me no hope for Analysis of Algorithm and Data Structures class, i have yet to find another book to assist me in this area. the book was so-what easy to read, but the explanation of the concepts is really horrible, dont waste ur money
The gears on the cover dont even work!.......2006-03-21
I have Dr Shaffer as my professor and he is just as boring in real life as his book. He has told us that some of the code segements are broken to make his students figure them out. DONT buy this book... It's not worth the money.
Anonymous.......2006-02-15
I would not reccomend this book for learning about data structures. With incomplete code and scampy sections on core area material, it seems to serve more as a workbook than anything else. In addition to this I find it to be poorly worded which has often caused me to overlook important details or have to read a sentence multiple times to understand what the author is saying. What saves this from being a one star product is the fact that if you do know the material, it can help you review structures but even then, the ackward wording still can slow down a quick read.
Very unhelpful book.......2005-11-29
Dr. Shaffer attempts to address the difficult topic of data structures and fails. Consistently he glosses over important points, or does not describe the implementation of data structures (the buffer pool, for example, is especially poor) adequately and leaves the hapless student confused and frustrated. For a computer scientist who already understands the subject this book may contain a few good points. Indeed, I was able to follow the sections where I had previous training, but when I studied material new to me, I was out of luck.
If you are unlucky enough to have a university that uses this text, consider trying to find a better book to get yourself an adequate understanding of this important subject, because Dr. Shaffer's text won't do that for you.
I normally buy books because they contain information..........2004-11-05
...but this was a mandatory book for my university's two-course Data Structures & Algorithms sequence that all computer scientists and computer engineers must take.
Coming in with a good deal of programming experience, I find that this book is not as clear or as complete as it could be. The sample code snippets throughout tend to be awkwardly implmented with obscure variable names and obtuse datatyping, and more often than not represent 'a' way of accomplishing a task rather than 'the best' way. Finding better ways of doing things is normally left for exercises at the end of the chapter; the answers are not included with the book.
Also, many significant details or comments are skimmed over or are ommitted from the text. Many important (and complex) observations are left as exercises - but again, the answers are not included, so there is no way of validating your answers.
Further, this book is targeted at the C++ language. It is obscene to discuss data structures and algorithms without mentioning the free, prepackaged, and optimized code of the C++ Standard Template Library. Indeed, this book and the code it includes would have benefitted from the ingenious architecture and software engineering behind the STL.
I really hope the campus bookstore will buy this one back when I'm done with it.
Book Description
This groundbreaking undergraduate textbook on modern Standard English grammar is the first to be based on the revolutionary advances of the authors' previous work, The Cambridge Grammar of the English Language (2002). The text is intended for students in colleges or universities who have little or no previous background in grammar, and presupposes no linguistics. It contains exercises, and will provide a basis for introductions to grammar and courses on the structure of English, not only in linguistics departments but also in English language and literature departments and schools of education.
Customer Reviews:
English Education majors and secondary English Teachers: check this out!.......2006-09-15
This text helped me to articulate the 'principles' of Standard English by examining our language in all its varieties scientifically and intuitively.
Such articulation necessates a thorough understanding of the notions of descriptive vs. prescriptive, standard vs. nonstandard, formal vs. informal, grammatical vs. ungrammatical, and constitutive vs. regulative.
This introductory text is written for the mature student who has had little or no background in linguistics or traditional school grammar. Consequently, the authors begin by demonstrating how traditional grammar instruction with its eight parts of speech and semantic definitions falls terribly short of accounting for the many rule exceptions and illogicalities of langauge.
I highly recommend this text for English Education majors and secondary school English teachers.
Book Description
This text offers the student a firm grounding in normal anatomy and physiology from an ultrasound perspective. After covering anatomy and physiology in the first half of each chapter, it then presents a wealth of ultrasound images to increase the reader's comfort with normal anatomy as it appears during scanning. Most images are accompanied by labeled drawings with detailed legends that explain what the reader is supposed to notice on the ultrasound scans. Instructor resources are available; please contact your Elsevier sales representative for details.
Customer Reviews:
Great book!.......2006-05-26
This book is an awesome resourse for someone who is just begining to learn ultrasound and need an overview of how the normal structures look like. It is very simple, consize, and easy to understand. IMHO the best feature this book has is the drawing of the visualized structures clearly marked, conveniently located right next to the actual sonographic image for comparison.
The Right Order: Normal Anatomy First.......2005-09-19
I believe a sound foundation in normal anatomy and physiology is the best course of study for the begininning sonography student. The textbook is clear, thorough and concise, and as a student who will be graduating next month, I highly recommend this book. I didn't find it until recently; I wish I had learned of this book earlier in my studies. Information on pathology would have been easier to absorb with a better foundation initially.
Amazon.com
The newest edition of the classic An Introduction to Database Systems incorporates the latest developments in relational databases, including semantic modeling, decision support, and temporal modeling. There's better information on distributed databases, security, and the mathematics of relational databases too. With the same strong coverage of fundamental theory that made its predecessors stand out, this book ranks as the definitive textbook for those studying database systems.
This is an extraordinarily academic book. In his preface, C.J. Date goes so far as to lament having to use Structured Query Language (SQL) in some of his examples because it's "so far from being a true embodiment of relational principles." What's more, he writes in a very academic style, peppering his heavily footnoted prose with mathematical expressions and words like relevar and tuple. The academic style and highbrow language isn't a bad thing, since this book deals with complicated, largely abstract phenomena in depth.
Be aware that An Introduction to Database Systems is a far cry from the highly graphical, problem-focused books that target the community of commercial database developers, and as such requires more careful study. This book is about theories, concepts, and ideals rather than problems, solutions, and specific implementations. Per se, it will enable you to become a better database programmer--but only if you supplement it with practical guides and hands-on experience. --David Wall
Customer Reviews:
When English is a set theory.......2007-09-03
I cannot believe so many people gave this book such high ratings.
Date has no clue on writing structured English. The man has more than 4 clauses per sentence and this is not including the clauses in the brackets.
Publishers need to pay more attention when editing.
Only logically conclusion is that Date thinks in SQL and hence his English looks like SQL.
Waste of money.
A great introduction to the theory and practice of database design.......2006-07-22
This is one of the better books on the theory of database systems design. It is not meant to be a book on applications, rather it is a commonly used textbook in upper level undergraduate and graduate classes on the subject. However, this latest edition has reorganized the material somewhat and has added to its sections on XML and SQL in an attempt to show the theory through more real-world scenarios.
The book is divided into six parts. The first section sets the scene by explaining what a database is and why database systems are generally desirable. Next a general architecture for database systems is presented that serves as a framework upon which all subsequent chapters are built. Next is a broad overview of relational systems and finally there is a chapter that introduces SQL and explains how it works and why it is not a perfect language.
The second section, on the relational model, is rather long. This reflects the fact that the relational model of database systems is the foundation that makes the field a science. The author does a good job of presenting the theory along with examples of this theory as practiced in SQL. However, remember that the SQL examples are to illuminate the theory, not vice versa. The author does an exceptional job of explaining the relational calculus.
The third section is dedicated to database design, and specifically relational database design. The database design problem can be stated very simply: Given some body of data to be presented in a database, how do we decide on a logical structure for that data? This section does an exceptional job of explaining and illustrating one of the more difficult concepts in database design, that of normalization and normal forms. Database normalization is a process that eliminates redundancy, organizes data efficiently, reduces the potential for anomalies during data operations, and improves data consistency.
The fourth section, on transaction management, will be familiar to those who are involved in operating system design. This section includes methods of protecting the database against non-deliberate threats such as a system crash in the middle of program execution that leaves the database in an unpredictable state, two programs concurrently executing that interfere with one another's operation therefore producing incorrect results, and updates that might change the database in an invalid way.
The fifth section, entitled "Further Topics", tackles a number of subjects that could be the topic of a complete book by themselves. This includes protecting databases against deliberate attacks, building optimization into databases so that they work more efficiently, handling missing database information, object-oriented concepts, and logic-based databases.
The final and sixth section of the book adds information on a subject that has been missing in past editions - that of object-oriented databases. This section includes some relevant information on the use of XML in database design.
I learned database design theory from the sixth edition of this book ten years ago with no prior database design experience. I found that edition to be a clear and adequate textbook but lacking in the discussions of alternatives to the relational model which has been corrected in this eighth edition. I highly recommend this book to students and professionals who are interested in learning about the theory of modern database design. All chapters begin with an introduction and end with a summary, exercises, and bibliography, so to prevent from being repetitive I do not show those sections in the table of contents shown below:
I. PRELIMINARIES
1. An Overview of Database Management
What is a database system?; What is a database?; Why database?; Data independence; Relational systems and others;
2. Database System Architecture
The three levels of the architecture; The external level; The conceptual level; The internal level; Mappings; The database administrator; The database management system; Data communications; Client/server architecture; Utilities; Distributed processing;
3. An Introduction to Relational Databases
An informal look at the relational model; Relations and relvars; What relations mean; Optimization; The catalog; Base relvars and views; Transactions; The suppliers-and-parts database;
4. An Introduction to SQL
Overview; The catalog; Views; Transactions; Embedded SQL; Dynamic SQL and SQL/CLI; SQL is not perfect;
II. THE RELATIONAL MODEL
5. Types
Values vs Variables; Types vs Representations; Type Definition; Operators; Type generators; SQL facilities;
6. Relations
Tuples; Relation types; Relation values; Relation variables; SQL facilities;
7. Relational Algebra
Closure revisited; The original algebra: Syntax; The original algebra: Semantics; Examples; What is the algebra for?; Further points; Additional operators; Grouping and ungrouping;
8. Relational Calculus
Tuple calculus; Examples; Calculus vs. algebra; Computational capabilities; SQL facilities; Domain calculus; Query-By-Example;
9. Integrity
A closer look; Predicates and propositions; Relvar predicates and database predicates; Checking the constraints; Internal vs external constraints; Correctness vs consistency; Integrity and views; A constraint classification scheme; Keys; Triggers (a digression); SQL facilities;
10. Views
What are views for?; View retrievals; View updates; Snapshots (a digression); SQL facilities;
III. DATABASE DESIGN
11. Functional Dependencies
Basic definitions; Trivial and nontrivial dependencies; Closure of a set of dependencies; Closure of a set of attributes; Irreducible sets of dependencies;
12. Further Normalization I: 1NF, 2NF, 3NF, BCNF; Nonloss decomposition and functional dependencies; First, second, and third normal forms; Dependency preservation; Boyce/Codd normal form; A note on relation-valued attributes;
13. Further Normalization II: Higher Normal Form
Multi-valued dependencies and fourth normal form; Join dependencies and fifth normal form; The normalization procedure summarized; A note on denormalization; Orthogonal design (a digression); Other normal forms;
14. Semantic Modeling
The overall approach; The E/R model; E/R diagrams; Database design with the E/R model; A brief analysis;
IV. TRANSACTION MANAGEMENT
15. Recovery
Transactions; Transaction recovery; System recovery; Media recovery; Two-phase commit; Savepoints (a digression); SQL facilities;
16. Concurrency
Three concurrency problems; Locking; The three concurrency problems revisited; Deadlock; Serializability; Recovery revisited; Isolation levels; Intent locking; ACID dropping; SQL facilities;
V. FURTHER TOPICS
17. Security
Discretionary access control; Mandatory access control; Statistical databases; Data encryption; SQL facilities;
18. Optimization
A motivating example; An overview of query processing; Expression transformation; Database statistics; A divide-and-conquer strategy; Implementing the relational operators;
19. Missing Information
An overview of the 3VL approach; Some consequences of the foregoing scheme; Nulls and keys; Outer join (a digression); Special values; SQL facilities;
20. Type Inheritance
Type hierarchies; Polymorphism and substitutability; Variables and assignments; Specialization by constraint; Comparisons; Operators, versions, and signatures; Is a circle an ellipse? Specialization by constraint revisited; SQL facilities;
21. Distributed Databases
Some preliminaries; The twelve objectives; Problems of distributed systems; Client/server systems; DBMS independence; SQL facilities;
22. Decision Support
Aspects of decision support; Database design for decision support; Data preparation; Data warehouses and data marts; Online analytical processing; Data mining; SQL facilities;
23. Temporal Databases
What is the problem?; Intervals; Packing and unpacking relations; Generalizing the relational operators; Database work design; Integrity constraints;
24. Logic-Based Databases
Overview; Propositional calculus; Predicate calculus; A proof-theoretic view of databases; Deductive database systems; Recursive query processing;
VI. OBJECTS, RELATIONS, AND XML
25. Object Databases
Objects, classes, methods, and messages; A closer look; A cradle-to-grave example; Miscellaneous issues;
26. Object / Relational Databases
The First Great Blunder; The Second Great Blunder; Implementation issues; Benefits of true rapprochement; SQL facilities;
27. The World Wide Web and XML
The Web and the Internet; An overview of XML; XML data definition; XML data manipulation; XML and databases; SQL facilities;
APPENDIXES.
Appendix A: The TransRelational(tm) Model
Three levels of abstraction; The basic idea; Condensed columns; Merged columns; Implementing the relational operators;
Appendix B: SQL Expressions, Table Expressions, and Boolean Expressions
Appendix C: Abbreviations, Acronyms, and Symbol
Appendix D: Online storage structures and access methods, database access: an overview, page sets and files, indexing, hashing, pointer chains, and compression techniques
the database practitioner's bible.......2005-08-18
I suppose there are two potential audiences for an introductory database book. The first audience consists of developers who need to know the very basics about databases to design and implement a database computer application. For that group I would recommend Date's book, but only upon having sufficient "computer science maturity": i.e. having taken one year of programming, and possibly a course in discrete mathematics and/or data structures and algorithms. Without this maturity much of what Date writes will be very hard to appreciate if not comprehend. True, he gives numerous examples that are quite understandable, but he also spends many paragraphs discussing somewhat abstract issues to the novice that will make him or her want to skip ahead. A good example of this is the notion of thinking of a table as the current value of a relvar, or the importance of closure in the relational algebra. The paragraphs he spends on these subtle importances will frustrate the uninitiated reader.
For someone who does not believe that he or she has the maturity to handle this book, and simply wants to develop an application that requires a database, I would recommend buying a more "down-to-earth" book possibly covering the RDMS that will be used. For example, if it is MySQL, then one might want to purchase
Welling's "MySQL Tutorial" (ISBN: 0672325845) for a much gentler and user-friendly introduction (or better yet the PHP and MySQL web development book if a web application is desired).
The other audience for this book are the professionals who are in charge of managing a database and/or using a database server for an industrial-strength application. In this case, Date's book is mandatory reading. May be not all of it, but certainly Parts I-IV. Reading these parts will give the professional the needed perspective on all the considerations required for successfully using or managing a database system.
In the world of database systems, Chris Date is one of the few authors who understands the importance of every minute detail involved with successfully using and managing databases. He proves that in this book, in a style that is not only academic but also quite useful and practical (especially his chapters on the relational algebra and calculus).
Best theoretical book on Database design ever!.......2004-04-03
I read this book for training as a senior DBA consultant and enjoyed CJ Date's excellent treatise on databases. This is the ultimate book on database theory. Like another reader commented its not how to get OCP/MCDBA whatever certifications but actually will make life better in the long run as a serious DBA pro. I now actually understand the basis of complex database topics such as cursors, data models, and concurrency/locking topics that previously are skimmed over in other books and training guides. Best book for a beginner and yeah its a bit dry and academic but CJ Date writes clearly. A MUST FOR SERIOUS COMPUTER SCIENCE STUDENTS!
A classic, to be read by any serious developer.......2004-01-07
Date's seminal work is critical to understanding databases - a step mostly forgotten by those who believe every concept can be taught using commercial products with brain-dead examples in under 24 hours. Date teaches the logic and theory that underlie all successful practice. You can probably buy a different book and create a mock database faster, but you will neither understand nor be able to use it well. Do yourself a favor and read this first to understand what a database is; only then can you judge the value of other books.
Average customer rating:
- Outstanding Resource!!
- Essential Resource
- The best
- Long awaited, exceeds expectations
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Child Care Design Guide
Anita Rui Olds
Manufacturer: McGraw-Hill Professional
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Designs for Living and Learning: Transforming Early Childhood Environments
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ASIN: 0070474494 |
Book Description
A-Z's for designing superior day care facilities
Virtually unknown 30 years ago, daycare has become a growth industry. Child Care Design Guide helps architects and designers plan, design, and renovate functional, developmentally rich, pleasing centers. Author Anita Rui Olds brings to this work over 25 years of design experience with children's facilities. She gives you step-by-step explanations of interior and exterior layout and design principles fleshed out in clarifying case studies. You learn about licensing and code requirements, operational standards and strategies, and get helpful checklists, charts and graphs for optimum facility design within time, space, and budgetary constraints. This highly visual work features over 300 floor plans for infant and toddler, preschool, and afterschool spaces, plus areas for outdoor play and more.
Customer Reviews:
Outstanding Resource!!.......2003-08-01
Worth every dime!!! Anita Rui Olds has incredible insight into creating environments that are reflective of children and their interests. She believes that a child care setting should have "spirit." Included are Reggio-type environmental solutions that create a sense of wonder with an architecturally aesthetic sensibility. Lots of great ideas packed into this book. Only regret is that the pictures are too small and not in color. Would have been worth extra [$$] to have an expanded edition.
Essential Resource.......2002-02-18
This is a terrific and necessary resource for anyone involved with the design or renovation of a child care setting. The author has clearly and concisely poured into the book her considerable knowledge and understanding of child care facilities, her passionate beliefs, and her attention to the details of good design. Her knowledge of child development is evident in all of her ideas.
The best.......2002-01-05
This must be the best book that exist about designing Child Care Center. It covers everything, but the most important is the focus the autor made on the children. This book is a must for every architect or people interested in design of this kind of buildings, specially if he/she is really interested in children well being.
The only but is that for the quality of its content, this book deserves a better paper and color pictures. (a 0 star here for MacGrow-Hill).
Probably this book is call to change the way a day care is seen today.
Long awaited, exceeds expectations.......2000-12-25
Preeminent authority on design for child care, Anita Rui Olds consummated a lifetime of deep concern and research into the needs of children with the publication of this magnum opus. Lavish use of illustrations--photos, sketches, floor plans, and examples--and attractive layout support Ms. Olds's incisive text to create a remarkably accessible book. Many hundreds of child care professionals and architects who have studied under Ms. Olds will recognize and welcome this work as the summation of the concepts that placed the author at the forefront of her field.
More and more children are in institutional care and, "in search of a model," day care typically happens in society's "leftover" spaces, church basements, warehouses, and places intended for adults. This book will help anyone committed to doing better for our children to "see that young children are raised in nurturing, spirited settings that honor their precious young souls." (from the introduction)
The book's only drawback is technical as the reproduction of photographs is of disappointing quality.
Tragically, Anita Olds did not live to see this book published. We can be thankful that she left it for us, full of her passion for children. In its use we will honor her spirit as we effect her designs.
Book Description
Chris Olsen has teamed up with Roxy Peck and Jay Devore to create INTRODUCTION TO STATISTICS AND DATA ANALYSIS. Based on STATISTICS: THE EXPLORATION OF ANALYSIS AND DATA, Fourth Edition, this new book integrates the graphing calculator and includes expanded coverage of probability. This innovative book focuses on the analysis of real data to motivate the study of statistics. Traditional in structure yet modern in approach, this book places an increased emphasis on data collection and exploratory analysis.
Customer Reviews:
expensive but a good deal.......2007-03-02
This book came quickly and was the correct version of the one I needed for my class. It was about $40 less expensive on Amazon than it was at my university's bookstore, but it's still a lot of money. I'm not sure if it's my computer or the CD, but I can't get the SPSS program to run. Overall, this book/CD was what I expected it to be at a relatively good price.
Recommended by Authors for Fuller Treatment of Probability.......2006-11-15
The authors are renowned for their work in producing clear, modern, thought-provoking statistics textbooks. This book differs from Statistics: The Exploration and Analysis of Data, 5th Ed. in that it has a more expansive discussion of probability. It also differs from that title in having more specific calculator exercises, but has the same great features of all editions of all textbooks from the same authors. Prefer this title to Statistics: The Exploration and Analysis of Data, 5th Ed. if you want more detail and depth on probability, and more practice with using an electronic calculator to explore statistics.
Book Description
Written in a clear and engaging style, and generously illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins. The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics. Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the vary great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why). To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.
Customer Reviews:
A nice introduction to structural biology.......2004-02-12
This book deserves 5 stars on the basis of its color stereo diagrams alone! Well done. I wish I had this book when I was starting out as a graduate student! A very good explanation of structural hierarchy. Plus the book also contains excellent details of structure of proteins belonging to specific families -for ex., antibodies. Even today, for my work, I find it very convenient to look into the book first for some structural information rather than into the PDB databases. And yes, I do have a very good pair of stereo glasses always on hand!
If Frank Lloyd Wright did proteins..........2001-02-01
This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The computer-generated renderings give pause to anyone who wonders what God was up to when She thought about creating life. Proteins, as represented here, are Her finest efforts. Visually stunning is only the most obvious aspect of this amazing introduction to structural genomics (proteinomics): the systematic study of protein structures. This is a serious graduate level textbook.
The text should be considered for any introductory graduate level course in biochemistry. Beginning with sound chemical principles, the text lays a solid foundation for the concepts of secondary and tertiary structure within protein. The author builds a superstructure from which to view the motifs of cofactor binding domains and active sites in enzymes.
Each chapter concludes with exercises, problems and "weblems". The weblems underscore the fact that structural genomics, a branch of bioinformatics, is a hot topic in the biotech arena. The weblems ask the reader to pursue ideas on the world wide web. The author provides the reader with a wealth of websites ranging from browser plug-in software for viewing crystal structures, to sources of those structures, to sequence alignment servers which will allow the student to do real research. Well thought-out, the weblems posed are useful to the student in exploring the topics of each chapter.
The author sticks to protein architecture avidly, issues of how proteins fold or how structure might be predicted from amino acid sequence are presented to the reader. It is a credit to the author that he does not speculate on these very hot research topics. The bibiliography for each chapter is current to mid-2000.
A student using this text will have greater insight and understanding of the literature of protein structure, folding, and prediction of structure. This book would also be a useful reference to the veteran practitioner, summarizing an early 21st century look at this field.
Book Description
Fully updated and expanded-a solid foundation for understanding experimental enzymology.
This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology.
Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descriptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics.
This
Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include:
- A new chapter on protein-ligand binding equilibria
- Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity
- Updated and refined discussions of enzyme inhibitors and multiple substrate reactions
- Coverage of current practical applications to the study of enzymology
Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis,
Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.
Customer Reviews:
Good book for steady state intial velocity measurements but.....................2007-02-15
.....not many people use steady state intial velocity measurements to gain insight into mechanism of biomolecules particularly enzymes these days. With that said, I do have to confess that I gave 4 stars to this book because
1) I think this is the only book (in my opinion) that gives answers to questions like what type of parameters you can get from steady state initial velocity measurements and how far you can take steady-state measurements to.
2) Occasionally, enzymes are not available in plenty, i.e., in substrate quantities and you are stuck with doing steady state kinetics and reading this book will be of use in this situation.
Here are my thoughts on the book.
The book begins with an introduction and a brief account of atoms, how they make bonds, what reactions are and why reactions have to be accelerated (rates). One thing that I found the book introduces nicely is that it clearly states how whether a reaction can occur or not depends on free energy (thermodynamics) but this does not tell us anything about the rates(1st and 2nd chapters).
The third chapter discusses aspects of protein structure beginning with amino acids, primary, secondary structures etc., just like any other biochemical text. The only thing that it lacks is a section on RNA enzymes - because proteins are not the only molecules capable of catalyzing reactions and RNAs can be catalytic. There is the very familiar Tetrahymena ribozyme (an RNA that can act as an enzyme) discovered by Tom Cech (he got the Nobel prize for the same).The fourth chapter focusses on enzyme-ligand binding equilbria. It also introduces the concepts of dissociation and association rate constants and how you can use these in determining the equilibrium binding constants. This is of practical importance because there are systems which take very long time to reach equilibrium and you cannot do equilibrium binding experiments - the only way here is to measure association and dissociation rate constants and get the binding constant from these. the chapter also has a nice table giving values of equilibrium constants and their corresponding free energy. commendable. my ohly concern is that it introduces linearizing of data such as reciprocal and double reciprocal plots which dont make intuitive sense and therefore not many good kineticists use them.
the fifth chapter goes into introducing practical concepts such as what is expected to see in reaction plots when you mix substrate and enzymes together. does a good job but there is no mention of how concentrations of both should be taken into account - which determine whether the reaction is single turnover (Enzyme does its thing only once) or multiple turnover (enzyme does its thing more than once). remember, this book is for purely steady state analysis. you cannot get individual rate constants from doing multiple turnover reactions. all you get is kcat and Km.
the sixth talks about mechanisms and the seventh about doing practical kinetics - here, it goes into why we see lag and burst in reactions sometimes. It also describes with some depth the effect of pH, why we have to maintain the pH, and destabilization of enzyme during reactions.
chapters eight, nine, ten and eleven discuss inhibitor kinetics (reversible and tight binding) and kinetics of enzymes with multiple substrates. All of these deal with measurement of intial velocities, again, remember this is a book with steady-state kinetics. There are a lot of inverse velocity and inverse subtrate plots that I cannot make any intuitive sense out of. The final chapter deals with cooperativity. although it gives a reasonably good introduction on it, the kinetic aspect is dealt with superfically. there arent a lot of kinetic plots but again, this is steady state initial velocity measurements and you can only take it so far.
A modern account of enzymes.......2005-01-08
Writing a new book of under 400 pages to cover the whole of enzymology is a courageous endeavour. Even if one confines attention to the general aspects that apply to many enzymes, and discusses only those specific mechanisms that are well established or illustrate important points, one can hardly escape the fact that the subject has become too vast to be easily summarized. Moreover, the sort of things that students want to know about enzymes differ according to whether their primary interests are in biochemistry, medicine, chemistry, engineering or molecular biology. Robert Copeland made some rather similar points in the Preface to the first edition of his book, and was honest enough to doubt whether it would be an exception to his conclusion that no single book could fulfil all of his students' needs. Nonetheless, it was successful enough to justify revising and expanding it after just four years, and the result is a worthy addition to the shelves of any enzymologist.
The book is addressed primarily to senior undergraduates or first-year graduates studying enzymology, and the emphasis is more on chemistry than on molecular biology, with definite leanings towards industrial applications. A brief account of the history of enzymology is followed by a second chapter that provides the real introduction to the book. This makes it clear that readers are expected to be able to cope with the basic chemical theory, including molecular orbitals, valence theory, resonance, thermodynamics and the theory of acids and bases. There is a lot of valuable information in this chapter, though weaker students will find the pace very fast. Fortunately the later chapters are more leisurely.
I'm not sure if it is fair to the author to mention the most obvious competitor to his book, Alan Fersht's Structure and Mechanism in Protein Science: a Guide to Enzyme Catalysis and Protein Folding. However, it is such an obvious competitor that potential readers are likely to think of it anyway, so it may be useful to compare the two books briefly. Fersht's book is much stronger on transient-state kinetics, and is more stimulating and even exciting. His is the more likely book to take to read in bed, but Copeland's is more thorough, especially in relation to topics that need to be taught but which are not very fashionable, like the kinetics of the steady state and the mechanistic features that can be deduced from the study of enzyme inhibition. It can be warmly recommended to any teacher needing a text that offers a solid introduction to enzymology.
A very useful Guide to Enzymes.......2004-01-22
This book is written by an enzymologist who presented a course on enzymology at a pharmaceutical company, as well as at the University of Pennsylvania. It is a rather well- written book that covers both theoretical and practical aspects of enzyme studies. Black and white drawings and numerous graphs illustrate the concepts. The book begins with a general review of some chemical concepts, including a brief review of thermodynamics, transition states in chemical reactions, acid-base concepts, non-covalent interactions and rates of chemical reactions. The next chapter covers aspects of enzyme (protein) structure. In a departure from other texts, the 4th chapter introduces and develops the concepts of protein-ligand binding equilibria. The derivation of Kd, along with the Langmuir isotherm to derive measurements at equilibrium is developed, as is treatment of equilibrium ligand binding data. The detour into non-enzymatic ligand-protein interactions is a very welcome treatment of this topic, so important in many drug interactions with receptors. While not strictly speaking enzymology, this chapter serves to introduce concepts that are further developed in the next chapter, which deals with the kinetics of enzymatic catalysis. This chapter nicely develops the basic equations and treatment of enzyme kinetics, and the steady state model is developed using the treatment of Briggs and Haldane. A discussion of the significance of both Km and Kcat is followed by methods to derive these values experimentally. After covering kinetics, the book moves on to chemical mechanisms of enzyme catalysis. The importance of transition state stabilization is discussed, and covalent catalysis and acid-base catalysis are highlighted. Serine proteases as model enzyme mechanisms round out the chapter.
Chapters 7 and 8 cover practical aspects of enzymology, such as velocity measurements, continuous versus end point reactions, detection methods for assays, and separation methods for reaction products (e.g., HPLC, TLC). Some pointers on enzyme concentration, temperature, pH and buffer effects on enzyme assays are valuable. The next chapter deals with reversible inhibitors, and describes the derivation of Ki. The distinctions among competitive, non-competitive and uncompetitive inhibition are discussed, and details on how to determine these in a practical sense are illustrated. There is also some discussion around the SAR of inhibitors, and this is tied in with inhibitor and drug design. Tight binding inhibitors get their own brief chapter, and there is a separate chapter on time dependent inhibition and the methodology around measuring this phenomenon. Enzyme reactions with multiple substrates and cooperativity in enzymatic catalysis also receive individual chapter treatments. Two appendices on suppliers and software tools round out the text.
Viva la Sequel!!.......2000-08-11
I never thought this could happen to me. I picked up the book and I was hooked instantly. Never before in my forays into biochemistry have I been this enchanted by such delightful prose. I started in a thermodynamic sink and I ended as an ultra-high energy intermediate. Copeland added a section on equilibrium binding that bound me with delight. His inhibitor sections loosened all my inhibitions. Even a chowder slurping ingrate from Harvard could understand and appreciate this work.
A real page-turner.......1999-02-16
In this gripping work, professor Copeland takes the reader on a roller-coaster ride through the thrilling activation energy peaks and local free energy minima of enzymology. From friendly Michealis-Menten kinetics to frightening multi-subtrate systems, Copeland holds the readers hand while unveiling his bold vision of the enzymatic universe. Even a Yalie could understand this post-modern classic.
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- Introduction to Solid State Physics
- Introduction to Space Physics (Cambridge Atmospheric & Space Science)
- Introduction to the Theory of Computation, Second Edition
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