An Introduction to Systems Biology: Design Principles of Biological Circuits (Chapman & Hall/Crc Mathematical and Computational Biology Series)

Book Description

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The text avoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Customer Reviews:

Clear, rigorous, fascinating.......2007-01-20

I'm a Ph.D. student in biophysics. This is the best treatment of systems biology that I've encountered. It treats both the math and the biology with clarity, rigor, and respect. It simplifies without dumbing down. It's beautifully written. If you doubt that systems biology is a real scientific discipline, this book will change your mind.

Building Mathematical Models of Cells.......2006-09-25

The history of science over the past few centuries is to become ever more specialized. The physicists, becomming ever more concerned with the very large (stars, galaxies, the cosmos) or the very tiny (first atoms, then atomic components, now sub-components. The biologists on the other hand were studying much larger things, such as the cells that make up life. Both sciences developed techniques to facilitate their study.

In recent years, researchers have discovered that sometimes these specialized techniques can be used to develop greater insight into what is happening in other sciences.

In this book, Dr. Alon uses his training in physics to examine certain aspects of biology and to use the terminology and mathematics to describe the way these biological networks work.

The goal of the book is to begin the formulation of general laws that apply to biological networks. This is done by providing a mathematical framework in which some of the design principles of biological systems can help to understand biological networks. In looking at the results, an underlying simplicity not seen before appears in biological systems.

Great Job.......2006-09-09

A superb intro to the field. The math is moderate and helpful. Network concepts and their ties to examples and theory are clearly and succinctly presented. This is a textbook but reads easily like a book. Covers key elements while connecting them by at least mention to up-to-date further research. The basics and the grandeur of systems biology. I am trying to remember now anything on the negative side and cannot.

The Anthropic Cosmological Principle (Oxford Paperbacks)

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700 Page Paperback
Modern cosmology.
NOT a Layman's guide to the Anthropic Cosmological Principle
What principle?
He's got the whole world... upside down!

The Anthropic Cosmological Principle (Oxford Paperbacks)
John D. Barrow , Frank J. Tipler , and John A. Wheeler
Manufacturer: Oxford University Press, USA
ProductGroup: Book
Binding: Paperback

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ASIN: 0192821474

Book Description

Is there any connection between the vastness of the universes of stars and galaxies and the existence of life on a small planet out in the suburbs of the Milky Way? This book shows that there is. In their classic work, John Barrow and Frank Tipler examine the question of Mankind's place in the Universe, taking the reader on a tour of many scientific disciplines and offering fascinating insights into issues such as the nature of life, the serach for extraterrestrial intelligence, and the past history and fate of our universe.

Customer Reviews:

700 Page Paperback.......2006-08-19

Originally published in late 1980s this book discusses what has come to be known as the `anthropic principle'. Barrow and Tippler are physicists and popular science writers.

This anthropic principle has been variously understood, but, in a general sense, it pertains to the relationship between the characteristics of the universe and our existence within the universe - i.e. the universe seems remarkably tuned for human life. A strong formulation of this principle would argue along the lines of "the universe was intended/designed for our type of life". While a weaker formulation would take the tact that these qualities are required in order to produce observers such as ourselves. I applaud the author's ambition in tackling this issue. They make a laudable effort to be comprehensive and attempt to cover the pertinent historic, philosophical and scientific ground.

Unfortunately, the book is too broad, as a result, at times it devolves into a litany of disparate quotes and facts that leaves the reader thinking; so what? Someone looking to get the gist of the types of questions addressed in this text is better looking at on-line sources such as Wikipedia (it has limits, but is a better entry point). I wonder who is the intended audience for this text? Anyone capable of following the discussion will likely find it superficial. While someone new to this area might find it impenetrable. Additionally, it is a 700-page pocketbook - the quotes are vanishingly small!

Despite the limitations of this book, the authors deserve some credit for their pioneering effort. I would, however, not recommend it. There is a tremendous range of outstanding popular works on the market that cover similar ground much more effectively - Greene, Ferris are especially good for the science aspects.

Modern cosmology........2005-09-08

A great book about the modern scientific theories on the origin and functioning of the universe.

NOT a Layman's guide to the Anthropic Cosmological Principle.......2005-08-03

Although this is a very extensive book, covering the Anthropic Cosmological Principle (which in short focuses on the fact that so many aspects of the cosmos and nature are finely tuned to make life possible) in a historical perspective, within cosmology, quantum theory, chemistry and biology, it is definitely not a book for the Layman. It includes a lot of mathematics, which I think should have been included in the references at the end of each chapter. However, when you filter those passages out, and focus on the main points, this book is a must-have and a classic for everyone with an open mind and interest in our place in this universe.

Rob (The Netherlands)

What principle?.......2005-06-04

Barrow is the chief advocate of the so-called "anthropic cosmological principle," which he treats in some detail in this book. There are two basic objections to this notion.

First, if chaotic inflation is correct then there should be an infinite number of universes out there, past, present and future, taking all possible physical constants. In this case, there should be no wonder that a certain percentage of these universes should happen to take fundamental constants (such as the ratio of the strength of the gravitational force versus that of the electromagnetic force) that are favorable to life. The law of large numbers means that it would be strange if NO universes should have life. A percentage of life-supporting or even life-suffusing universes would be infinite if the number of "baby" or "bubble" universes out there is indeed infinite. If a large enough number of people buy the Powerball lottery, then some people are bound to win sooner or later, no matter how small the odds. Feeling that life is special because the physical constants in our universe require "fine tuning" would be like saying that if you are the Powerball winner, that's because the lottery was designed for you and you only. And that's absurd. The jackpot is given to whoever has the winning ticket, and not just you. And more importantly, the lottery was never designed with giving away prizes as its primary goal - it was designed to bring in revenue. Winners are just an inevitable side-effect of the whole scheme. If you win, you're merely lucky. But there is nothing special about you. Of course, a lottery must have winners or else the lottery would not work. The difference between lotteries and nature is that there is no reason to suppose that life is necessary in order for universes to exist.

We can all feel life is special for other reasons, but one should not argue that this is because nature is the way it is in order that life exists without also asking why it doesn't exist in SO MANY other places. And even if our universe is the only possible one (such a view is no longer acceptable), it is still a matter of debate among physicists as to whether fine tuning actually occurred.

The other objection is that this so-called "principle" is really just an interpretation, and is in no way a scientific principle comparable to the laws of mechanics or natural selection. Sir Martin Rees says "anthropic reasoning" would be more appropriate. It does not command general consent among scientists, and is thus more like a philosophical school of thought than a genuine scientific principle. To elevate anthropic ideas to the status of "principles" is exaggerated and misleading.

In my view, scientists like Barrow who win the Templeton Prize are disqualified thereby, somewhat like athletes who test positive for banned drugs. I'm not suggesting that scientists cannot have religious beliefs (and I was surprised to know that Andre Linde, a founder of chaotic inflation, also does). I only insist that scientific research should not be misused for religious purposes. Barrow can perhaps point to distinguished scientists like Freeman Dyson and John Wheeler for sympathy with his views. But I think this only shows that even distinguished scientists can be in serious error. Nobel Laureate in Physics Steven Weinberg, who thinks more clearly about these matters than most, finds that the Weak Anthropic Principle is nothing more than "mystical mumbo jumbo" (because it's just common sense to say that if the physical constants had been any different we would not have existed), and that the Strong Anthropic Principle is unbelievable because our universe is probably not the only one.

The main virtue of this book is the breadth of its coverage and the range of subjects discussed. Its erudition is broad rather than deep.

He's got the whole world... upside down! .......2005-04-13

Dear Frank Tipler. In case you don't know, it was God who created the Universe, and not the other way around.

He is the Alpha and Omega points. He is not a creation of nature. He is the Creator of nature. Nature is the Beta point. Are you intelligent and wise enough to get that?

Once you understand this simple truth, everything will start to fit in and feel right, and it will help a lot to clear up your helplessly confused and senseless thoughts and speculations. Right now you have it upside down. You have to change your assumptions and renew your mind, as the Apostle Paul has put it.

You see, once your starting assumptions are wrong, the brighter you are the worse is the trouble your reasoning gets you in.

By the way, the thousands of anthropic coincidences that can be found in the macro and micro spheres of the Universe are exactly what biblical creationism would predict.

Molecular Imaging: Principles And Applications In Biomedical Research

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Summarizes the Current State of the Art

Molecular Imaging: Principles And Applications In Biomedical Research
Markus Rudin
Manufacturer: Imperial College Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1860945287

Product Description

Molecular imaging is a rapidly emerging field that translates many concepts developed for molecular biology and cellular imaging to the in vivo imaging of intact organisms. The technique allows the study of molecular biological events in their full context and will therefore become an indispensable tool for biomedical research and drug discovery and development. This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities and the design of target reporter constructs are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events: the biodistribution of drugs/ligands, the expression of drug targets (receptors, enzymes), and the consequences of the molecular drug-target interactions (pathway activations, system responses). A final chapter deals with visualization of cell migration (cell therapies).

Customer Reviews:

Summarizes the Current State of the Art.......2006-03-11

It seems that with the ability to get any signal at all through a body, the modern day imaging systems can produce an image with useful information. In this book various signal generating systems (I guess you would call them) be it X-Ray tomography, magnetic resonance, and nuclear imaging are discussed.

This is followed with a discussion on the various techniques for reporting the images. Finally the book discusses the uses of these imaging techniques in examining the actions of drugs in living animals. These techniques are non-invasive so that what the drug is doing can be observed in real time. This is extremely important as getting the drug to the proper location in the patient where it can work is of the utmost in importance. Other uses of the technology are likewise discussed such as cell migration.

This book represents a good summary of the state of the art as it exists today and points in some of the directions that research is going in this rapidly emerging field.

Intelligent Life in the Universe: Principles and Requirements Behind Its Emergence (Advances in Astrobiology and Biogeophysics)

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Well-organized and easy to read
Impressive, though technical and mathematical
a complete picture of astrobiology

Intelligent Life in the Universe: Principles and Requirements Behind Its Emergence (Advances in Astrobiology and Biogeophysics)
P. Ulmschneider
Manufacturer: Springer
ProductGroup: Book
Binding: Hardcover

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Astrobiology: A Multi-Disciplinary Approach

ASIN: 3540439889

Book Description

This book addresses all scientists and others interested in the origins, development and fate of intelligent species in the observable part of our universe. In particular, the author scrutinizes what kind of information about extraterrestrial intelligent life can be inferred from our own biological, cultural and scientific evolution and the likely future of mankind. The first part of the book provides the necessary background information from space and life sciences, thus making the book also accessible to students and the scientifically educated public.

Customer Reviews:

Well-organized and easy to read.......2004-10-08

I truly enjoyed reading this book. It is carefully written, has an enormous amount of up-to-date information, and covers the subject reasonably well. Astrobiology is a relatively new subject, and this is one of the best books about it. I was very impressed by the amount of material Ulmschneider was able to cover in only 250 pages and how clearly he explained everything. He went through the origin of the chemical elements, planet formation, the threat of planetary migration, the search for extrasolar planets, planetary atmospheric instabilities, theories on the origin of life on Earth, the evolution of life, the threats to the Earth's environment from the existence of life (such as the Huronic glaciation), the search for extraterrestrial life, and much more. That included some speculative material, some of which I found dubious. But that does not detract from the overall value of this book.

Impressive, though technical and mathematical.......2003-11-04

In this densely written book, Heidelberg University professor Peter Ulmschneider covers a remarkably wide range of questions related to extraterrestrial life and intelligence, and does so with convincing authority. His work, part of Springer's Physics and Astronomy series, has the flavor of a university textbook, with numerous graphs, tables, and diagrams, and a few equations. Readers will need either a basic knowledge of science or a willingness to learn while reading.

Part I, about planets, discusses the origin of chemical elements, planet formation, the search for extrasolar planets, and planets suitable for life. Part II, about life, begins at the most basic level of organic chemistry, then moves on to a condensed discussion of biological evolution on Earth. A much briefer chapter provides a quick overview of the search for extraterrestrial life. Part III, on intelligence, takes an unusual approach by beginning with the future of Humankind, emphasizing human expansion into the solar system and possible threats to our survival. Ulmschneider argues that, by thinking about our own future development, we can gain insights into the nature of extraterrestrial intelligence. He concludes his book with a discussion of extraterrestrial intelligent life, briefly noting some of the proposed explanations for the Fermi Paradox.

This book is not for casual readers. Because it covers so much territory, the discussions are highly condensed. Nonetheless, Ulmschneider has done an impressvie job. The book includes some small but well-reproduced colored pictures.

a complete picture of astrobiology.......2003-06-04

This book was so dense with information and so elegantly organized that I found it easier than most recreational reading I do these days. The author explains how one might answer what I consider to be the ultimate question: Is there intelligent life elsewhere in the universe? The author refrains from pontificating his own opinion, but rather provides the background information necessary for the reader to draw his or her own conclusions. The basics of planetary science, astrophysics, and biology are presented in the first section, followed by a description of the conditions in which life has evolved, and where elsewhere in the universe we might find such conditons. Part three (the section that I found to be the most fascinating) described the nature of intelligent life and the fate of humanity. As a student studying astrobiology, I found that this book did an amazing job of unifying many of the classes I have taken, and painted a very good picture of Astrobiology as a sigle subject. I would recommend the book to anyone intersted in astrobiology, space exploration, or the future of mankind. The material presented was sufficiently detailed for a student to gain insight, yet presented in such a simple manner that even the casual reader would walk away with and understanding of the contents.

Principles of Environmental Physics, Third Edition

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Good reference to make you look smart at work

Principles of Environmental Physics, Third Edition
John Monteith , and Mike Unsworth
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0125051034

Book Description

Environmental Physics concerns the description and analysis of physical processes that establish the conditions in which all species of life survive and reproduce. The subject involves a synthesis of mathematical relations that describe the physical nature of the environment and the many biological responses that environments evoke. Environmental Physics provides a basis for understanding the complex responses of plants and animals to environmental change.

International concern with climate change has made both politicans and the general public much more aware of the impact of local and global weather on all aspects of domestic life, industry and commerce. Environmental Physics has become more widely used by biologists, atmospheric scientists and climate modellers to specify interations between surfaces and the atmosphere. This new edition contains further material on causes of global warming, applications of remote sensing, and the carbon and water cycles of crops and forests.

* Presents a unique synthesis of micrometeorology and ecology in its widest sense.
* Deals quantitatively with the impact of weather on living systems but also with the interactions between them that are a central feature of life on earth
* Includes an up-to-date bibliography and review of recent micrometeorological applications in forestry, ecology, hydrology and agriculture
* Includes numerical problems and worked examples

Customer Reviews:

Good reference to make you look smart at work.......2007-06-08

Okay, so this is not a great beach read, page turner, or anything you want on your coffee table. But it is nice book to have on your shelf in your office if you do work in environmental or climate science. In all honesty, I will probably never use 99% of the stuff that this book contains, but when I need an equation for heat or mass transport, radiation, etc., I usually find it in this book. It probably is most useful for those in satellite remote sensing and image processing or in environmental or climate modeling, as it contains a considerable amount of information on the effect of difference surfaces on radiation and wind patterns. The last two chapters contain detailed equations for crop micro-meteorology and sum up most of the principles in the book.

Average customer rating:

Good introductory book, but not enough depth
OK book, but not very useful toward a specific class
Good survey text of medical imaging techiques & technologi

Principles of Medical Imaging
K. Kirk Shung , Michael B. Smith , and Benjamin M. W. Tsui
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 0126409706

Book Description

Since the early 1960's, the field of medical imaging has experienced explosive growth due to the development of three new imaging modalities-radionuclide imaging, ultrasound, and magnetic resonance imaging. Along with X-ray, they are among the most important clinical diagnostic tools in medicine today. Additionally, the digital revolution has played a major role in this growth, with advances in computer and digital technology and in electronics making fast data acquisition and mass data storage possible. This text provides an introduction to the physics and instrumentation of the four most often used medical imaging techniques.
Each chapter includes a discussion of recent technological developments and the biological effects of the imaging modality. End-of-chapter problem sets, lists of relevant references, and suggested further reading are presented for each technique.

Key Features
* X-ray imaging, including CT and digital radiography
* Radionuclide imaging, including SPECT and PET
* Ultrasound imaging
* Magnetic resonance imaging

Customer Reviews:

Good introductory book, but not enough depth.......2004-11-25

This book would make a perfect companion for an introductory course in medical imaging or for someone who does not have an engineering background, but the book would have more appeal if a more in-depth treatment on the math. and physics of imaging is given. Simply too superficial.

OK book, but not very useful toward a specific class.......2001-01-10

It is a pretty conprehensive and deep book and definitely covers a lot of medical imaging techniques. However, it did not help too much in my biomedical imaging class Duke University.

Good survey text of medical imaging techiques & technologi.......1998-03-10

This book provides introductory overviews of X-ray, ultrasound, MRI, and radionuclide medical imaging techniques and technologies. I found it to be an excellent text for anyone with a scientific background wanting to quickly understanding these different imaging techniques. Each chapter makes liberal use of charts, diagrams, and images to quickly convey key concepts. Each chapter also provides a long list of references for further reading. A very clear, easy-to-read text.

Principles of Ocean Physics (International Geophysics Series)

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Principles of Ocean Physics (International Geophysics Series)
John R. Apel
Manufacturer: Academic Press
ProductGroup: Book
Binding: Hardcover

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Book Description

In recent years, significant advances in both the theoretical and observational sides of physical oceanography have allowed the ocean's physical behavior to be described more quantitatively. This book discusses the physical mechanisms and processes of the sea, and will be valuable not only to oceanographers but also physicists, graduate students, and scientists working in dynamics or optics of the marine environment.

Laws of the Game : How the Principles of Nature Govern Chance ( Princeton Science Library )

Average customer rating:

Do yourself a favor and read this
5 for Content, 3 for Readability

Laws of the Game : How the Principles of Nature Govern Chance ( Princeton Science Library )
Manfred Eigen , and Ruthild Winkler
Manufacturer: Princeton University Press
ProductGroup: Book
Binding: Paperback

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ASIN: 0691025665

Book Description

Using game theory and examples of actual games people play, Nobel laureate Manfred Eigen and Ruthild Winkler show how the elements of chance and rules underlie all that happens in the universe, from genetic behavior through economic growth to the composition of music.

To illustrate their argument, the authors turn to classic games--backgammon, bridge, and chess--and relate them to physical, biological, and social applications of probability theory and number theory. Further, they have invented, and present here, more than a dozen playable games derived from scientific models for equilibrium, selection, growth, and even the composition of RNA.

Customer Reviews:

Do yourself a favor and read this.......2007-06-27

This book changed my view of things by supplying a logical basis for the relation among particles and giving me a new view of randomness and order. This is one of the most important books I ever read. Read it slowly. Don't worry if you have to read a sentence several times. It is worth it.

5 for Content, 3 for Readability.......2007-01-09

The content is fantastic, and I'm incredibly glad I purchased this book (actually, it was a gift). I'm only about halfway through, but already have ideas for a few dozen applications I want to implement based on the information contained there. Always a dabbler in game theory, it's nice to have my understanding of it expanded beyond _The Evolution of Cooperation_.

My only complaint is that it is very difficult to read. Translated from the German, it lost something along the way. I find myself rereading sections again and again- and not just because it's a little above my level of expertise but also because the translation is a bit opaque.

That complaint though is minor. Excellent work, and I'm ready to start applying this to software projects.

Introduction to the Principles of Medical Imaging

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Introduction to the Principles of Medical Imaging
Chris Guy , and Dominic Ffytche
Manufacturer: Imperial College Press
ProductGroup: Book
Binding: Hardcover

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ASIN: 1860945023

Book Description

The introduction of X-ray computed tomography (CT) 25 years ago revolutionized medical imaging; X-ray CT itself provided the first clear cross-sectional images of the human body, with substantial contrast between different types of soft tissue. The enduring legacy of CT is, however, the spur that it gave to the subsequent introduction of tomographic imaging techniques into diagnostic nuclear medicine and the extraordinarily rapid development of magnetic resonance imaging (MRI) over this period.

This book is a non-mathematical introduction to the principles underlying modern medical imaging, taking tomography as its central theme. The first three chapters cover the general principles of tomography, a survey of the atomic and nuclear physics which underpins modern imaging, and a review of the key issues involved in radiation protection. The subsequent chapters deal in turn with X-ray radiography, gamma imaging, MRI and ultrasound. The clinical role of diagnostic imaging is illustrated in the final chapter through the use of fictional clinical histories. Three appendices provide a more mathematical background to the tomographic method, the principles of mathematical Fourier methods, and the mathematics of MRI.

This revised edition includes new introductory sections on the relevant physics of molecules in general, and water, in particular. Every chapter now has a table of key points with cross-references to other sections. Several figures have also been revised.

Book Description

Providing extensive coverage of the field, this book brings together the latest developments, theories, research and concerns from both a scientific and
social perspective. Beginning with an introduction on approaching environmental problems, the text then moves on to look at climatic change, energy conversion, the transport of pollutants, experimental methods and ends with a discussion on science and society.

Features:

Extensive coverage of the latest concerns, issues and developments within the field from both a scientific and social perspective
Numerous relevant examples and mini-case studies (appetisers) combined with exercises in each chapter and references for further reading
A supplementary website where students can access experiments and simple models relevant to the book: www.nat.vu.nl/envphysexp

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